Association between particulate matter air pollution and lung cancer

Zhang, Zhenyu; Zhu, Dawei; Cui, Bin; Ding, Ruoxi; Shi, Xuefeng; He, Ping

doi:10.1136/thoraxjnl-2019-213722

Cited by 61 publications

(43 citation statements)

References 9 publications

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“…A growing body of evidence indicates that lung cancer incidence is associated with exposure to PM 2:5 (IARC 2013;Bai et al 2020;Zhang et al 2020). The present study supports this evidence, with a statistically significant IRR of 1.19 (95% CI: 1.09, 1.30), even after conservatively adjusting for multiple comparisons (p = 0:01).…”

Section: Discussionsupporting

confidence: 84%

“…Much of the epidemiological evidence to support this association, however, is based on prospective cohort studies that examined lung cancer mortality, not lung cancer incidence. Although several recent studies have used incidence data to estimate the association between PM 2:5 and lung cancer (IARC 2013;Bai et al 2020;Zhang et al 2020), further research is needed to confirm the association and examine the sensitivity of the results to modeling choices and exposure windows.…”

Section: Introductionmentioning

confidence: 99%

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Fine Particulate Matter Exposure and Cancer Incidence: Analysis of SEER Cancer Registry Data from 1992–2016

Coleman

Burnett²,

Ezzati

et al. 2020

Environ Health Perspect

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BACKGROUND: Previous research has identified an association between fine particulate matter (PM 2:5) air pollution and lung cancer. Most of the evidence for this association, however, is based on research using lung cancer mortality, not incidence. Research that examines potential associations between PM 2:5 and incidence of non-lung cancers is limited. OBJECTIVES: The primary purpose of this study was to evaluate the association between the incidence of cancer and exposure to PM 2:5 using >8:5 million cases of cancer incidences from U.S. registries. Secondary objectives include evaluating the sensitivity of the associations to model selection, spatial control, and latency period as well as estimating the exposure-response relationship for several cancer types. METHODS: Surveillance, Epidemiology, and End Results (SEER) program data were used to calculate incidence rates for various cancer types in 607 U.S. counties. County-level PM 2:5 concentrations were estimated using integrated empirical geographic regression models. Flexible seminonparametric regression models were used to estimate associations between PM 2:5 and cancer incidence for selected cancers while controlling for important county-level covariates. Primary time-independent models using average incidence rates from 1992-2016 and average PM 2:5 from 1988-2015 were estimated. In addition, time-varying models using annual incidence rates from 2002-2011 and lagged moving averages of annual estimates for PM 2:5 were also estimated. RESULTS: The incidences of all cancer and lung cancer were consistently associated with PM 2:5. The incident rate ratios (IRRs), per 10-lg=m 3 increase in

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Fine Particulate Matter Exposure and Cancer Incidence: Analysis of SEER Cancer Registry Data from 1992–2016

Coleman

Burnett²,

Ezzati

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Most studies have explored the relationship between betel nuts, cigarettes, or alcohol and oral cancer, but few studies have studied the relationship between air pollution and oral cancer. PM is typically a representative indicator of air pollution [2,4]. Compared to PM10, PM2.5 can cause greater harm to human health [4].…”

Section: Discussionmentioning

confidence: 99%

“…PM is typically a representative indicator of air pollution [2,4]. Compared to PM10, PM2.5 can cause greater harm to human health [4]. PM2.5 generally penetrates the lung barrier and enters the blood system.…”

Section: Discussionmentioning

confidence: 99%

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Lee

et al. 2020

J. Cancer

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Recently, many studies have indicated that ambient air particulate matter (PM) can increase the risk of oral cancer. The most common malignant tumor in the oral cavity is oral squamous cell carcinoma (OSCC). Usually, cancer cell migration/invasion is the most important cause of cancer mortality. Matrix metalloproteinase-2 (MMP-2) and MMP-9 have been shown to play important roles in regulating metastasis and the tumor microenvironment. Here, we studied the anti-cancer effects of surfactin, a cyclic lipopeptide generated by Bacillus subtilis, on cancer cell migration and invasion. Surfactin suppressed PM-promoted cell migration and invasion and colony formation of SCC4 and SCC25 human oral squamous cell carcinoma cell lines. We observed that PM induced MMP-2 and MMP-9 expression, which was inhibited by surfactin. Transfection with p65, p50, c-Jun, c-Fos, p85, p110, Akt, mammalian target of rapamycin (mTOR), or interleukin-6 (IL-6) siRNA markedly inhibited PM-induced MMP-2 and MMP-9 expression. Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. Finally, we proved that transfection with Akt, p65, or c-Jun siRNA significantly inhibited PM-induced IL-6 release. Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-κB (NF-κB) and activator protein-1 (AP-1)/IL-6 signaling pathways.

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“…Seventeen cohort studies in nine European countries showed an association between residential exposure to particulate matter air pollution and the risk for lung cancer. One study using a random 5% sample of China Urban Employee Basic Medical Insurance (UEBMI) also showed the increased risk of lung cancer associated with increasing long-term PM2.5 air pollution exposure from 1 January 2010 to 31 December 2016 [1,2]. Several prospective cohort studies in North America and Europe have evaluated the effects of long-term exposure to outdoor air pollution and demonstrated associations between ambient air pollution exposure with respiratory disease, cardiovascular disease and lung cancer [3,4].…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Incidence of Lung Cancer by Histological Type in Korean Adults: A Korean National Health Insurance Service Health Examinee Cohort Study

Moon

Kwon

Kim

et al. 2020

IJERPH

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Studies have reported associations between long-term exposure to ambient air pollution and lung cancer. However, there have been inconsistent reports of such associations with lung cancer by histological type. Thus, the aim of this study was to assess the association of long-term exposure to particulate matter with an aerodynamic diameter up to 10 μm (PM10) and nitrogen dioxide (NO2) with lung cancer incidence by histological subtype in South Korea. This population-based cohort study included 6,567,909 cancer-free subjects from the Korean National Health Insurance Service (NHIS) database for 2006–2007. We linked population data to Korea Central Cancer Registry data to confirm lung cancer incidence for 2006–2013. Individual exposures to PM10 and NO2 were assessed as five-year average concentrations predicted at subjects’ district-specific home addresses for 2002–2007. We divided these exposures into two categories based on the 75th percentile. Cox proportional hazards models were used to estimate hazard ratios (HRs) of lung cancer incidence for the upper 25% exposure compared to the low 75% by histological subtypes at diagnosis after adjusting for potential confounders. A total of 27,518 lung cancer were found between 2006 to 2013. The incidence of lung cancer was higher in males, smokers, drinkers and subjects with chronic obstructive pulmonary disease. Overall, we did not find an increased risk of lung cancer with higher exposure to PM10 or NO2. However, high exposure to PM10 was associated with increased risk of adenocarcinoma in comparison with lower exposure in males and current smokers (HR, 1.14; 95% CI, 1.03–1.25). This study showed that long-term air pollution exposures were associated with an elevated risk of lung adenocarcinoma in male smokers in Korea.

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Association between particulate matter air pollution and lung cancer

Cited by 61 publications

References 9 publications

Fine Particulate Matter Exposure and Cancer Incidence: Analysis of SEER Cancer Registry Data from 1992–2016

Fine Particulate Matter Exposure and Cancer Incidence: Analysis of SEER Cancer Registry Data from 1992–2016

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Air Pollution and Incidence of Lung Cancer by Histological Type in Korean Adults: A Korean National Health Insurance Service Health Examinee Cohort Study

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