Association between Parkinson's disease and risk of colorectal cancer

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

“…Interestingly, a tyrosine kinase inhibitor of platelet-derived growth factor receptor, imatinib, was widely used to treat CML and significantly ameliorated survival in murine lupus autoimmune disease 65 . In addition, association between CRC and PD has been reported in several observational cohorts 66, 67 . Collectively, these findings strongly support our hypothesis that human complex diseases sharing similar microbiome features might be mechanically correlated.…”

Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions

“…We found two studies regarding PD and colorectal cancer (CRC) (Boursi et al, 2016;Xie et al, 2016). The first one included an extensive series of 22,093 CRC cases, in which PD was identified in 117 (0.5%).…”

“…Regarding some particular tumors, Xie et al (2016) studied the possible mechanisms related to colorectal cancer and PD. Different hypotheses have been proposed to explain the inverse association between both conditions (Louis et al, 2014).…”

Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases

“…These symptoms were found to be elevated in 24.3% of the PD patients versus 5.3% of controls. Another example of a potential interplay between the gut and PD relates to the reduced risk of colorectal cancer as reported by 2 studies with high numbers of patients and matched controls [41, 42]. The assumption that PD correlates also with intestinal dysbiosis was recently tested in a mouse model of the disease: mice that overexpressed α-synuclein displayed decreased pathophysiological signs upon antibiotics treatment [43].…”

“…As far as changes observed in human PD patients are concerned, the results are conflicting, which might be due to differences in sample collection, preparation, and analysis. One example where those discrepancies are obvious is the family Prevotellaceae: 2 reports describe a decreased number in fecal samples of PD patients [41, 44], whereas 2 other studies report no significant deviation from healthy controls [45, 46] and 1 investigation describes even elevated numbers of this family in PD patients [47]; however, samples here were taken from the oral cavity. An example where the literature seems to be more consistent is the family Lactobacillaceae, with at least 3 reports showing elevated numbers [45-47].…”