Association between PAHs biomarkers and kidney injury biomarkers among kitchen workers with microalbuminuria: A cross-sectional pilot study

Singh, Amarnath; Kamal, Ritul; Tiwari, Ratnakar; Gaur, Vivek Kumar; Bihari, Vipin; Satyanarayana, G.N.V.; Patel, Devendra Kumar; Azeez, P. A.; Srivastava, Vikas; Ansari, Afzal; Kesavachandran, Chandrasekharan Nair

doi:10.1016/j.cca.2018.10.021

Cited by 23 publications

(4 citation statements)

References 56 publications

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“…Findings from some studies support the evidence that occupational exposure to fire emissions may induce local inflammatory response in firefighters with the subsequently initiation of a systemic response that will culminate in adverse health consequences (Gianniou et al, 2016;Gaughan et al, 2014b;Ferguson et al, 2016). Regarding other occupationally exposed groups, Singh et al (2018) found significant and positive correlations between urinary 9-hydroxyfluorene and 1OHPy with some acute kidney injury biomarkers (kidney injury molecule 1 and tissue inhibitor of metalloproteinases) in Indian male kitchen workers with microalbuminuria, thus suggesting that occupational exposure to PAHs may cause kidney injury. Alhamdow et al (2017) reported that urinary PAH metabolites of chimney workers were positively associated with diastolic blood pressure.…”

Section: Relation Between Biomarkers and Cardio-respiratory Parametersmentioning

confidence: 61%

Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

Oliveira

Costa

Vaz

et al. 2020

Journal of Hazardous Materials

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Firefighters represent one of the riskiest occupations, yet due to the logistic reasons, the respective exposure assessment is one of the most challenging. Thus, this work assessed the impact of firefighting activities on levels of urinary monohydroxyl-polycyclic aromatic hydrocarbons (OHPAHs; 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenzo(a)pyrene) and genotoxic/oxidative-effect biomarkers (basal DNA and oxidative DNA damage) of firefighters from eight firehouses. Cardiac frequency, blood pressure and arterial oxygen saturation were also monitored. OHPAHs were determined by liquid-chromatography with fluorescence detection, while genotoxic/oxidative-effect biomarkers were assessed by the comet assay. Concentrations of total OHPAHs were up to 340% higher (p ≤ 0.05) in (nonsmoking and smoking) exposed workers than in control subjects (non-smoking and non-exposed to combat activities); the highest increments were observed for 1-hydroxynaphthalene and 1-hydroxyacenaphthene (82-88% of ∑OHPAHs), and for 2-hydroxyfluorene (5-15%). Levels of biomarker for oxidative stress were increased in non-smoking exposed workers than in control group (316%; p ≤ 0.001); inconclusive results were found for DNA damage. Positive correlations were found between the cardiac frequency, ∑OHPAHs and the oxidative DNA damage of non-smoking (non-exposed and exposed) firefighters. Evidences were raised regarding the simultaneous use of these biomarkers for the surveillance of firefighters' health and to better estimate the potential short-term health risks.

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Section: Relation Between Biomarkers and Cardio-respiratory Parametersmentioning

confidence: 61%

Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

Oliveira

Costa

Vaz

et al. 2020

Journal of Hazardous Materials

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“…PAHs, such as Naphthalene, are extremely carcinogenic, can induce kidney and liver damage, cause redness and irritation of skin through dermal contact and cause red blood cell destruction when breathed. Primarily the industrial workers exposed to PAHs and other chemicals were shown to have an elevated risk of skin, lung, bladder, and gastrointestinal malignancies in many studies 89 . PAHs metabolites are related to increased risk of atherosclerotic cardiovascular disease (ASCVD) in the general population, changing the heart rate variability (HRV), an early marker of cardiac autonomic imbalance 90 .…”

Section: Resultsmentioning

confidence: 99%

Source identification and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in air and dust samples of Lahore City

Aslam

Sharif

Baqar

et al. 2022

Sci Rep

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During two consecutive summer and winter seasons in Lahore, the health risk of air and dust-borne polycyclic aromatic hydrocarbons (PAHs) was evaluated. Gas chromatography/mass spectrometry (GS/MS) was used to determine air and dust samples from various functional areas across the city. The mean ∑16PAHs were higher in air 1035.8 ± 310.7 (pg m−3) and dust 963.4 ± 289.0 (ng g−1 d.w.) during winter seasons as compared to summer seasons in air 1010.9 ± 303.3 (pg m−3) and dust matrices 945.2 ± 283.6 (ng g−1 d.w.), respectively. PAHs ring profile recognized 3 and 4 rings PAHs as most dominant in air and dust samples. Estimated results of incremental lifetime cancer risk (ILCR) highlighted high carcinogenic risk among the residents of Lahore via ingestion and dermal contact on exposure to atmospheric PAHs. The total ILCR values in air among children (summer: 9.61E − 02, winter: 2.09E − 02) and adults (summer: 1.45E − 01, winter: 3.14E − 02) and in dust, children (summer: 9.16E − 03, winter: 8.80E − 03) and adults (summer: 1.38E − 02, winter: 1.33E − 02) during the study period. The isomeric ratios in the study area revealed mixed PAH sources, including vehicular emission, petroleum, diesel and biomass combustion. As a result, it is advised that atmospheric PAHs should be monitored throughout the year and the ecologically friendly fuels be used to prevent PAHs pollution and health concerns in the city. The findings of this study are beneficial to the local regulating bodies in terms of controlling the exposure and promoting steps to reduce PAHs pollution and manage health in Lahore.

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“…For restaurant air quality, with dominant use of biomass, no reference studies can be found. Some studies had such kitchens as subject, but no air pollutant measurements were conducted (Juntarawijit & Juntarawijit, 2017;Mahembe et al, 2010;Singh et al, 2018). Within restaurant visitor areas, studies are related to smoking (for example, Konstantopoulou et al, 2014;Williams Jr et al, 2014), or to Chinese cooking styles, cooking oils & deep frying (Lee et al, 2001;Lee et al, 2002;Zhao et al, 2010).…”

Section: Limitations and Recommendationsmentioning

confidence: 99%

An Evaluation of Best Practices in an Air Quality Student Science Project in Ethiopia

Dingemanse

Wit

2022

AQUADEMIA

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A science project as part of a student's curriculum, which we call student science, might be the answer to two problems for a low-income country like Ethiopia: conventional science can be expensive and many students lack training in practical skills. Earlier studies have been conducted with respect to lay people (citizens or students) conducting (parts of) research (e.g. citizen science), but rarely in the context of a public university in a lowincome country. A student science project at Arba Minch University (Ethiopia) has been evaluated in three steps. Firstly, best practices for student science projects are derived from the literature. Secondly, it is evaluated to what extent these best practices were executed in an air quality student science project executed by 33 groups of undergraduate students at Arba Minch University. Thirdly, the scientific contribution of the project is evaluated by assessing the quality of the data in comparison to studies in similar scenarios, as well as its relation to a knowledge gap and a problem for the community. We find that the best practices from earlier studies are feasible in the study context. Furthermore, we find a scientific contribution, as most of the students' work resulted in quality data that relates to knowledge gaps which are a problem for the Arba Minch community. Student science at a public university in a low-income country is feasible and can, as such, serve both scientific and educational needs. It is recommended that public universities in low-income contexts implement part of their curriculum goals in such projects.

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Association between PAHs biomarkers and kidney injury biomarkers among kitchen workers with microalbuminuria: A cross-sectional pilot study

Cited by 23 publications

References 56 publications

Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

Source identification and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in air and dust samples of Lahore City

An Evaluation of Best Practices in an Air Quality Student Science Project in Ethiopia

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