Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Park, Chul-Hyun; Lee, Yong Taek; Yoon, Kyung Jae

doi:10.1038/s41598-021-02640-1

Cited by 8 publications

(7 citation statements)

References 56 publications

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“…[55] This technique can provide surface topographic images and electronic structures at an atomic resolution. [67] DFT is an efficient tool for simulating and calculating the atomic and electronic structures, reaction paths, and states of intermediates during reactions, and has been widely utilized to elucidate the inner structure of NMP-SACs. [68] For example, in Wu's work, DFT was conducted to simulate the optimized structure of Co NP@SAs-NC.…”

Section: Other Characterization Techniquesmentioning

confidence: 99%

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Nanoscale Metal Particle Modified Single‐Atom Catalyst: Synthesis, Characterization, and Application

Chen

Wang

et al. 2023

Advanced Materials

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Single‐atom catalysts (SACs) have attracted considerable attention in heterogeneous catalysis because of their well‐defined active sites, maximum atomic utilization efficiency, and unique unsaturated coordinated structures. However, their effectiveness is limited to reactions requiring active sites containing multiple metal atoms. Furthermore, the loading amounts of single‐atom sites must be restricted to prevent aggregation, which can adversely affect the catalytic performance despite the high activity of the individual atoms. The introduction of nanoscale metal particles (NMPs) into SACs (NMP‐SACs) has proven to be an efficient approach for improving their catalytic performance. A comprehensive review is urgently needed to systematically introduce the synthesis, characterization, and application of NMP‐SACs and the mechanisms behind their superior catalytic performance. This review first presents and classifies the different mechanisms through which NMPs enhance the performance of SACs. It then summarizes the currently reported synthetic strategies and state‐of‐the‐art characterization techniques of NMP‐SACs. Moreover, their application in electro/thermo/photocatalysis, and the reasons for their superior performance are discussed. Finally, we address the challenges and perspectives of NMP‐SACs for the future design of advanced catalysts.This article is protected by copyright. All rights reserved

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Section: Other Characterization Techniquesmentioning

confidence: 99%

“…[ 55 ] This technique can provide surface topographic images and electronic structures at an atomic resolution. [ 67 ]…”

Section: Characterization Techniquesmentioning

confidence: 99%

Nanoscale Metal Particle Modified Single‐Atom Catalyst: Synthesis, Characterization, and Application

Chen

Wang

et al. 2023

Advanced Materials

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“…A recent study, undertaken in more than 5900 subjects without overt cardiovascular diseases, suggests that osteosarcopenia is an important predictor element for coronary artery calcification in asymptomatic adults [ 81 ].…”

Section: Sarcopenia and Osteosarcopenia Unavoidable Signs Of Agingmentioning

confidence: 99%

Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge

Galasso

Cappella

Mulè

et al. 2023

IJMS

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Autophagy dysregulation is commonplace in the pathogenesis of several invalidating diseases, such as musculoskeletal diseases. Polyamines, as spermidine and spermine, are small aliphatic cations essential for cell growth and differentiation, with multiple antioxidant, anti-inflammatory, and anti-apoptotic effects. Remarkably, they are emerging as natural autophagy regulators with strong anti-aging effects. Polyamine levels were significantly altered in the skeletal muscles of aged animals. Therefore, supplementation of spermine and spermidine may be important to prevent or treat muscle atrophy. Recent in vitro and in vivo experimental studies indicate that spermidine reverses dysfunctional autophagy and stimulates mitophagy in muscles and heart, preventing senescence. Physical exercise, as polyamines, regulates skeletal muscle mass inducing proper autophagy and mitophagy. This narrative review focuses on the latest evidence regarding the efficacy of polyamines and exercise as autophagy inducers, alone or coupled, in alleviating sarcopenia and aging-dependent musculoskeletal diseases. A comprehensive description of overall autophagic steps in muscle, polyamine metabolic pathways, and effects of the role of autophagy inducers played by both polyamines and exercise has been presented. Although literature shows few data in regard to this controversial topic, interesting effects on muscle atrophy in murine models have emerged when the two “autophagy-inducers” were combined. We hope these findings, with caution, can encourage researchers to continue investigating in this direction. In particular, if these novel insights could be confirmed in further in vivo and clinical studies, and the two synergic treatments could be optimized in terms of dose and duration, then polyamine supplementation and physical exercise might have a clinical potential in sarcopenia, and more importantly, implications for a healthy lifestyle in the elderly population.

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“…Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using a standardized sphygmomanometer after resting for 5 min according to the Hypertension Detection and Follow-up Program protocol [31]. Hypertension was defined as having a measured blood pressure ≥ 140/90 mmHg, a self-reported physician diagnosis, or the current use of antihypertensive medication based on the criteria from the 8th report of the Joint National Committee [32,33].…”

Section: Measurements Of Biochemical and Clinical Parametersmentioning

confidence: 99%

Association of Pulmonary Function with Osteosarcopenic Obesity in Older Adults Aged over 50 Years

et al. 2023

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Osteosarcopenic obesity (OSO) is a newly described coexistence of osteopenia/osteoporosis, sarcopenia, and obesity. We examined the association between pulmonary function, OSO, and its composition in adults aged ≥ 50 years. A total of 26,343 participants (8640 men; 17,703 women) were classified into four groups based on the number of abnormal body compositions (osteopenia/osteoporosis, sarcopenia, and obesity): 0 (control), 1+, 2+, and 3+ (OSO) abnormal body compositions. The values of forced volume vital capacity (FVC)%, forced expiratory volume in 1 s (FEV1%), and FEV1/FVC% were significantly decreased by increasing the number of adverse body compositions (p < 0.0001). Although the prevalence of restrictive spirometry pattern (RSP) was positively associated with a higher number of abnormal body composition parameters (p < 0.001), obstructive spirometry pattern (OSP) had no association with adverse body composition. In multivariate analyses, the adjusted odds ratios (ORs) for RSP compared to the control group were 1.36 in 1+, 1.47 in 2+, and 1.64 in 3+ abnormal body compositions (p for trend < 0.001). Multiple abnormal body composition, especially osteosarcopenic obesity, was independently associated with poor lung function showing RSP in older adults over 50 years. The coexistence of these abnormal body compositions may be a predisposing factor for pulmonary function deterioration.

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Association between osteosarcopenia and coronary artery calcification in asymptomatic individuals

Cited by 8 publications

References 56 publications

Nanoscale Metal Particle Modified Single‐Atom Catalyst: Synthesis, Characterization, and Application

Nanoscale Metal Particle Modified Single‐Atom Catalyst: Synthesis, Characterization, and Application

Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge

Association of Pulmonary Function with Osteosarcopenic Obesity in Older Adults Aged over 50 Years

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