Association Between Osteoprotegerin G1181C and T245G Polymorphisms and Diabetic Charcot Neuroarthropathy

Pitocco, Dario; Zelano, Giovanni; Gioffrè, Giuseppina; Stasio, Enrico Di; Zaccardi, Francesco; Martini, Francesca; Musella, Tittania; Scavone, Giuseppe; Galli, Matteo; Caputo, Salvatore; Mancini, L; Ghirlanda, Giovanni

doi:10.2337/dc09-0243

Cited by 71 publications

(65 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This inflammation may be caused by minor trauma, surgery, infection or earlier ulceration, and the possibility of a genetic predisposition to abnormal signalling through inflammatory pathways has been suggested [7].…”

mentioning

confidence: 99%

Audit of acute Charcot’s disease in the UK: the CDUK study

et al. 2011

View full text Add to dashboard Cite

Aims/hypothesis We studied factors associated with the development and resolution of acute Charcot foot using a web-based observational study. centres. Of these, 36% of patients recalled an episode of relevant trauma in the preceding 6 months, while 12% had had surgery to the affected foot. In 101 (35%) cases, ulceration was present at registration and 20% of these had osteomyelitis. Non-removable off-loading devices were used at presentation in 35.4% of cases, with removable off-loading used in 50%. Data on resolution were available for 219 patients. The median time to resolution was 9 months in patients whose initial management included the use of non-removable off-loading, compared with 12 months in the remainder (p=0.001). Bisphosphonates were administered intravenously in 25.4% and orally in 19.4% of cases. The median time to resolution in patients who received bisphosphonates was 12 months and was longer than in those who did not (10 months, p=0.005). Conclusions/interpretation The median time to resolution was longer than in earlier series. Although limited by being observational and non-randomised, these data suggest that the use of non-removable off-loading at presentation may shorten the time to resolution. They provide no evidence to indicate that the use of bisphosphonates is beneficial.

show abstract

mentioning

confidence: 99%

Audit of acute Charcot’s disease in the UK: the CDUK study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…18,19 Available at http://www3.interscience.wiley.com/cgi-bin/fulltext/117966610/main. html,ftx_abs-b20#b20.…”

Section: Genotypingmentioning

confidence: 99%

Assessment of the Genetic Effects of Polymorphisms in the Osteoprotegerin Gene, TNFRSF11B, on Serum Osteoprotegerin Levels and Carotid Plaque Vulnerability

Straface

Biscetti

Pitocco

et al. 2011

Stroke

Self Cite

View full text Add to dashboard Cite

Background and Purpose-Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. Various mechanisms have been suggested by which calcification might alter atherosclerotic plaque stability, but the significance of this intimal calcification is controversial. High concentrations of OPG have been associated with the presence of vascular and cardiovascular diseases. This study was designed to assess the association between gene polymorphisms of the OPG gene (TNFRSF11B), the serum OPG level, and plaque stability in patients with carotid atherosclerosis. Methods-We studied 177 patients with internal carotid artery stenosis who underwent carotid endarterectomy and also 303 controls. Carotid endarterectomy samples removed from patients were assessed by immunohistochemistry. Concentrations of OPG were measured and gene polymorphisms were examined by polymerase chain reaction and restriction enzyme analysis and were compared, initially between patients with carotid atherosclerosis and controls, and subsequently between stable and unstable carotid plaques. Results-We found that the GG genotype of the T245G polymorphism, the CC genotype of the T950C polymorphism, and the CC genotype of the G1181C polymorphism were significantly higher in patients with carotid plaque than in controls (21.5% versus 10.9% , PϽ0.01; 15.8% versus 7.6%, PϽ0.01; and 20.3% versus 10.9%, PϽ0.01, respectively) and that these polymorphisms were associated with high serum OPG levels (4. A therosclerosis is a disease of the elastic and large muscular arteries in which atheroma is the characteristic lesion. The lesions of atherosclerosis enlarge the arterial intima with variable amounts and types of lipids, connective tissues, inflammatory cells, and a variety of extracellular components including matrix proteins, enzymes, and calcium deposits. 1 In the past, calcification of normal tissue has been recognized as a common component of atherosclerotic lesions. 2 Some evidence suggests that calcification of atherosclerotic arteries is an organized, regulated process, rather than being a passive phenomenon of aging. 3,4 Several factors related to bone and mineral formation have been demonstrated within atherosclerotic plaques; these include osteocalcin, osteopontin, osteonectin, osteoprotegerin (OPG), and bone morphogenetic proteins. 5,6 The presence of these factors indicates the potential of arterial wall cells to promote Received March 3, 2011; accepted June 10, 2011 The human OPG gene (8q24; TNFRSF11B) consists of 5 exons and 4 introns and is transcribed into 4 transcripts (2.4 kb, 3.0 kb, 4.2 kb, and 6.5 kb lengths). The gene encoding for OPG is affected by common, functionally important genetic polymorphisms that have been associated with osteoporosis 13 and are considered early predictors of cardiovascular disease 14 ; among the most important are the T245G (rs 3134069), located in the promoter region, the T950C (rs 2073617) located in the 5Ј untranslated region, and the G1181C (rs 2073618) located ...

show abstract

“…10 Abbreviations: CI -confidence interval, n -number of alleles, N -total number of alleles, OR -odds ratio, SNP -single nucleotide polymorphism to be associated with male sex. This association was observed also when comparing the prevalence of the C allele of the rs2073618 polymorphism between patients with diabetic foot and those only with diabetes.…”

Section: Resultsmentioning

confidence: 99%

“…[4][5][6][7][8][9] Recent studies have proved a link between the TNFRSF11B gene T245G and C1181G polymorphisms and the prevalence of Charcot neuroarthropathy. 10 Diabetic foot is a diabetic complication of varied etiology leading to delayed wound healing and even amputation of the lower limb.…”

Section: Methodsmentioning

confidence: 99%