Association between onychodystrophy and human T-lymphotropic virus type 1 infection

Mayer, Erick F.; Ita, Fanny; González, Elsa; Verdonck, Kristien; Bravo, Francisco; Clark, Daniel; Gotuzzo, Eduardo

doi:10.1016/j.ijid.2012.11.009

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Superinfection with these organisms leads to chronic antigen stimulation and therefore chronic inflammation of the skin, which manifests as a recalcitrant eczematous dermatitis that responds best to antibiotic therapy . HTLV‐1 infected individuals in general have higher prevalence of skin diseases including dermatophytoses, seborrheic dermatitis, and acquired ichthyosis that may reach 76% …”

Section: Discussionsupporting

confidence: 54%

“…3 HTLV-1 infected individuals in general have higher prevalence of skin diseases including dermatophytoses, seborrheic dermatitis, and acquired ichthyosis that may reach 76%. 3,9,10 The histopathology of HTLV-1 associated infective dermatitis is nonspecific and often similar to atopic dermatitis. 1 It shows a chronic spongiotic dermatitis with acanthosis, hyperkeratosis, parakeratosis, and mild to moderate lymphocytic infiltrates in the epidermis and dermis.…”

Section: Discussionmentioning

confidence: 99%

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Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Weiler

Mayer

Kazlouskaya

et al. 2018

Pediatric Dermatology

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Infective dermatitis (ID) associated with Human T‐cell leukemia virus type‐1 (HTLV‐1) is a rare form of severe superinfected eczema seen mostly in the Caribbean islands and Latin America. Although rapid response to antibiotic treatment is observed, patients should be monitored for development of complications associated with this retroviral infection, including T‐cell leukemia/lymphoma (ATLL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Infective dermatitis is rarely seen in the United States and therefore may be under‐recognized by physicians unfamiliar with this condition. Herein, we present an additional case report of an ID associated with HTLV‐1 in an 11‐year‐old girl from Trinidad.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Weiler

Mayer

Kazlouskaya

et al. 2018

Pediatric Dermatology

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“…En nuestra paciente se evidenció la presencia de onicodistrofia, que es una asociación independiente con infección por HTLV-1. Esta infección podría tener un mayor riesgo para onicomicosis debido al daño de la superficie de la uña y una respuesta inmune mediada por células T disminuido (15) . La concentración del virus en plasma es bastante baja.…”

Section: Discussionunclassified

Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

Loja-Oropeza¹,

Zavala-Flores

Vilca-Vásquez

2016

Rev Peru Med Exp Salud Publica

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Paciente mujer de 55 años de edad, natural de Ayacucho, con antecedente de dermatomiositis desde hace 3 años, recibió tratamiento irregular con prednisona. Dos meses antes del ingreso presenta anemia hemolítica autoinmune y púrpura trombocitopénica idiopática, recibió pulsos de metilprednisolona y transfusión de paquetes globulares. Al ingreso, soporosa, mal estado general, marcada pérdida ponderal, deshidratada, livedo reticularis en miembros inferiores, onicodistrofia y onicolisis múltiple en los dedos de ambos pies. Western Blot positivo para HTLV-1. Evoluciona con hipoglicemia recurrente. Reportamos un caso de dermatomiositis y síndrome de Evans presentados en el contexto de una infección por virus linfotrópico humano tipo 1. Palabras clave: Anemia hemolítica autoinmune; Dermatomiositis; Virus 1 linfotropico T humano (fuente: DeCS-BIREME). DERMATOMIOSITIS AND EVANS SYNDROME ASSOCIATED WITH HTLV-1 INFECTIONA 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lower extremities, and onychodystrophy and onycholysis on the toes of both feet. Western blot test was positive for human T-lymphotropic virus type 1 (HTLV-1). The patient evolved with recurrent hypoglycemia. Therefore, we report a case of dermatomyositis and Evans syndrome in the context of an HTLV-1 infection. Key words: Anemia, hemolytic, autoimmune; Dermatomyositis; Human T-lymphotropic virus 1 (source: MeSH NLM). INTRODUCCIÓNLa infección por el virus linfotrópico humano (HTLV-1) es una enfermedad emergente en Latinoamérica. Es endémica en países como Brasil, Colombia, Perú y afecta principalmente a poblaciones quechuas, afroamericanos y descendientes de japoneses, alcanzando una prevalencia global de 0,5-5%. En el Perú, la prevalencia varía entre 1,3 a 3,8%, considerándose una infección endémica. La transmisión de HTLV-1 ocurre a través de tres vías: sexual, de madre a niño (sobre todo a través de lactancia materna) y por transfusión de sangre (1,2) .Entre las formas clínicas relacionadas a la infección por HTLV-1 existen tres grupos más o menos bien definidos que incluyen en el primer grupo a enfermedades con manifestaciones inflamatorias como el síndrome de Sjögren, tiroiditis, alveolitis, nefritis intersticial, uveítis, polimiositis-dermatomiositis (PM-DM) y la paraparesia espástica tropical. Un segundo grupo contempla neoplasias como la leucemia de células T del adulto y el linfoma cutáneo. En el tercer grupo se consideran a las infecciones como la sarna noruega, la dermatitis infectiva, la onicomicosis múltiple, la tuberculosis, la hiperinfestación por Strongyloides stercolaris, la lepra y la paracoccidiodomicos...

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Cutaneous Lymphomas

Whittaker,

Child

2016

Rook's Textbook of Dermatology, Ninth Edition

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Primary cutaneous lymphomas are extranodal non‐Hodgkin lymphomas and consist of different variants defined by specific clinicopathological and immunophenotypic features. Primary cutaneous T‐cell lymphomas are the most common subset and are derived from resident memory T cells, whereas primary cutaneous B‐cell lymphomas are more closely related to their nodal counterparts with derivation from B cells at different stages of differentiation. Whilst the underlying pathogenesis of cutaneous lymphomas remains unclear, there is emerging evidence for a heterogenous pattern of somatic mutations and epigenetic events. Although the prognosis for many indolent primary cutaneous lymphoma variants remains excellent, the treatment of some rare variants and advanced stages of mycosis fungoides and Sezary syndrome represents an unmet medical need in view of high levels of chemotherapy resistance and limited durable responses. A variety of novel biological agents have been recently approved but long‐term remissions are rare. There is still an urgent need to clarify the underlying molecular pathogenesis and identify more effective targeted therapies for mycosis fungoides and Sézary syndrome.

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Association between onychodystrophy and human T-lymphotropic virus type 1 infection

Abstract: There is an independent association between HTLV-1 infection and onychodystrophy. Patients with an HTLV-1 infection might have a higher risk for onychomycosis given the abnormal nail plate and a decreased T-cell-mediated immunologic response.

Cited by 7 publications

References 21 publications

Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Infective dermatitis associated with HTLV‐1 infection in a girl from Trinidad: Case report and review of literature

Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

Cutaneous Lymphomas

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