Association between of temperature-sensitive transient receptor potential cation channel, subfamily V, member 3 (TRPV3) with preoperative pain in women with breast cancer

Aouizerat, Bradley E.; Dunn, Lisa; Cooper, Bruce A.; Paul, Soumen; West, Claudia; Miaskowski, C.

doi:10.1016/j.jpain.2011.02.102

Cited by 1 publication

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“…It has been reported that the high expression of TRPV3 will cause pain in pancreatic cancer, bone cancer and breast cancer [ 21 ]. Patients often experience pain before breast cancer surgery, and there is evidence that this pain is due to the high expression of TRPV3 [ 56 , 66 , 67 , 68 ]. Birgit Hoeft et al analyzed 392 single nucleotide polymorphisms of 43 genes associated with fatty acid metabolism and the risk of colorectal cancer in a study involving 1225 cancer patients and 2032 noncancer controls.…”

Section: Diseases Related To Trpv3mentioning

confidence: 99%

“…In addition, TRPV3 is closely related to pain. The overexpression of TRPV3 has been found in skin pain, breast pain, cancer pain and other pain tissues [ 56 , 57 , 58 ]. The relevant evidence has shown that the TRPV3 channels in the epidermis are involved in sensory conduction, but the TRPV3 channels in the skin keratinocytes do not form synapses with the sensory nerve terminals.…”

Section: Diseases Related To Trpv3mentioning

confidence: 99%

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TRPV3: Structure, Diseases and Modulators

Xue

Wang

et al. 2023

Molecules

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Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31–39 °C), and it plays an important regulatory role in temperature perception, pain transduction, skin physiology, inflammation, cancer and other diseases. TRPV3 is not only activated by the changes in the temperature, but it also can be activated by a variety of chemical and physical stimuli. Selective TRPV3 agonists and antagonists with regulatory effects and the physiological functions for clinical application are highly demanded. In recent years, significant progress has been made in the study of TRPV3, but there is still a lack of modulators with a strong affinity and excellent selectivity. This paper reviews the functional characteristics of TRPV3 in terms of the structure, diseases and the research on TRPV3 modulators.

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