Association Between Obstructive Sleep Apnea and Sudden Sensorineural Hearing Loss&lt;subtitle&gt;A Population-Based Case-Control Study&lt;/subtitle&gt;

Sheu, Jau-Jiuan; Wu, Cheng-Shong; Lin, Herng‐Ching

doi:10.1001/archoto.2011.227

Cited by 35 publications

(36 citation statements)

References 37 publications

(39 reference statements)

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“…Different authors in the past examined the effects of sleep apnea episodes on auditory sensitivity and the possible association between OSAS and hearing disorders [27,28], analyzing mainly the auditory brainstem function through ABR recording. However, to our knowledge, few of them focused on the inner ear dysfunction and data about TEOAEs and high frequencies (9-16 kHz) audiometry are scarce.…”

Section: Discussionmentioning

confidence: 99%

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Martines

Ballacchino

Sireci

et al. 2015

Eur Arch Otorhinolaryngol

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The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS). Sixty (37.5 %) patients were not affected by OSAS, 58 (36.25 %) presented a mild OSAS, 18 (11.25 %) a moderate OSAS and 24 (15 %) a severe OSAS; the 57.14 % of moderate to severe OSAS suffered from tinnitus with respect to the 31.03 % of mild OSAS (P = 0.024). A higher percentage (41.66 %) of hearing loss was found among individuals with moderate to severe degree of OSAS (P \ 0.0001). All groups were characterized by a mean hearing threshold \25 dB HL for 0.25-3 kHz frequencies and a progressive decrease in hearing sensitivity, particularly for 6-16 kHz frequencies (P \ 0.05). The analysis of otoacoustic emissions SNR mean values evidenced a significant difference between simple snoring and severe OSAS individuals for 3 and 4 kHz frequencies (P \ 0.05). d-ROM levels resulted higher in patients with severe OSAS with respect to simple snoring subjects (P = 0.004). Our data underline the key role of chronic nocturnal intermittent hypoxia in the development of an early cochlear damage and a more marked high-frequency hearing loss in case of severe OSAS (P \ 0.05).

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Section: Discussionmentioning

confidence: 99%

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Martines

Ballacchino

Sireci

et al. 2015

Eur Arch Otorhinolaryngol

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“…13,[17][18][19] Only a few studies examining the link between SA and HI have been conducted, and results are inconsistent. 20,21 Moreover, no prior large, population-based studies have obtained standardized objective measures of both hearing and sleep as well as potential confounding variables. 17,18 Using data from the largest study of US Hispanics/Latinos to date with standardized SA and audiometry testing, we examined the association between SA and HI.…”

Section: Brief Summarymentioning

confidence: 99%

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos

Chopra

Jung

Kaplan

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objective: Sleep apnea (SA) may promote hearing impairment (HI) through ischemia and inflammation of the cochlea. Our objective was to assess an independent association between SA and HI in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants. Methods: We used data from the HCHS/SOL, a multicenter population-based study of self-identifying Hispanic/Latinos 18-to 74-y-old adults from four US urban communities. We performed home SA testing and in-clinic audiometry testing in all participants. SA was defined as an apnea-hypopnea index (AHI) ≥ 15 events/h. HI was defined as a mean hearing threshold > 25 dB hearing level in either ear at the frequencies: 3,000 to 8,000 Hz for high-frequency HI (HF-HI) and 500 to 2,000 Hz for low-frequency HI (LF-HI). Combined-frequency HI (CF-HI) was defined as both conditions present, and Any-HI was considered as HI in either low or high frequencies. Results: Of 13,967 participants, 9.9% had SA and 32.3% had Any-HI. Adjusted for risk factors for HI, those with SA had a 30% higher odds of Any-HI (95% confidence interval [CI] = 8% to 57%), 26% higher odds of HF-HI (CI = 3% to 55%), 127% higher odds of LF-HI (CI = 21% to 326%), and 29% higher odds of CF-HI (CI = 0% to 65%). A dose-response association was observed between AHI severity and Any-HI (versus no SA, OR for AHI ≥ 15 and < 30 = 1.22, CI = 0.96 to 1.54, and OR for AHI ≥ 30 = 1.46, CI = 1.11 to 1.91, p = 0.002). Conclusion: SA is associated with HF-HI and LF-HI, independent of snoring and other confounders. Commentary: A commentary on this article appears in this issue on page 641.

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“…According to a prior study, all 359 cities/towns in Taiwan were stratified into 5 groups ranked by urbanization level. 16 We further ensured that patients selected for the comparison cohort had never been diagnosed with DD, schizophrenia, or bipolar disorder prior to their index date.…”

Section: Study Samplementioning

confidence: 99%

Obstructive Sleep Apnea and the Subsequent Risk of Depressive Disorder: A Population-Based Follow-up Study

Chen

Keller

Kang³

et al. 2013

Journal of Clinical Sleep Medicine

113

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Association Between Obstructive Sleep Apnea and Sudden Sensorineural Hearing Loss<subtitle>A Population-Based Case-Control Study</subtitle>

Abstract: Male patients with SSNHL had a higher proportion of prior OSA than non-SSNHL-diagnosed controls; no such association was found among female patients. Further study will be needed to confirm our findings, explore the underlying pathomechanisms, and investigate the difference between sexes.

Cited by 35 publications

References 37 publications

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos

Obstructive Sleep Apnea and the Subsequent Risk of Depressive Disorder: A Population-Based Follow-up Study

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