Association between obstructive sleep apnea and Alzheimer's disease-related blood and cerebrospinal fluid biomarkers: A meta-analysis

Kim

2022

J Korean Med Sci

Background The relationships between obstructive sleep apnea (OSA) and diverse types of pain disorders have been reported. However, the interaction between OSA and pain-related temporomandibular disorder (TMD) remains obscure. Methods A total of 60 adults (male/female, 48/12; mean age, 41.7 ± 13.2 years) with pain-related TMD were enrolled. All participants underwent overnight full-channel polysomnography and had assessment of size and position of the tongue, tonsillar size, height, and weight. Diagnostic Criteria/TMD criteria was applied to diagnose TMD. Myofascial trigger points (TrPs) were bilaterally evaluated in the two masticatory and four cervical muscles including the temporalis, masseter, trapezius, sternocleidomastoid, occipitalis, and splenius capitis muscles. Participants were divided into three groups in accordance with their levels of OSA. Results The significantly higher number of active TrPs were detected in participants with severe OSA. The number of active TrPs in the masticatory muscles significantly interacted with diverse types of apneic and arousal indices. Conclusion The myofascial pain modulating mechanisms and jaw function could have interactions with nocturnal hypoxia and sleep fragmentation in chronic pain-related TMD patients.

Section: Discussionmentioning

confidence: 99%

“… 4 Many previous studies have focused on the consequences of untreated OSA such as cardiovascular diseases, cognitive impairment, and increase risk of mortality. 5 6 7 8 9 Therefore, prompt diagnosis and management of OSA is critical for reducing the possibilities of developing its comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Potential Role of Obstructive Sleep Apnea on Pain Sensitization and Jaw Function in Temporomandibular Disorder Patients

Kim

2022

J Korean Med Sci

“…Obstructive sleep apnea (OSA) is one of the most prevalent sleep-related breathing disorders in the general population and it is accompanied by diverse types of comorbidities, such as cardiovascular diseases, cognitive impairment, traffic accident, depression, and increased risk of mortality 15 - 19 . OSA may cause sleep fragmentation and nocturnal hypoxemia which is related to hyperalgesia.…”

Section: Introductionmentioning

confidence: 99%

Associations between obstructive sleep apnea and painful temporomandibular disorder: a systematic review

Lee

2022

JKAOMS

The relationship between obstructive sleep apnea (OSA) and diverse types of pain conditions have been proposed. However, no consensus on the relationship between OSA and painful temporomandibular disorders (TMDs) has been established. Therefore, this systematic review has been conducted to review the existing literatures and provide comprehensive synthesis of such literatures about OSA and painful TMDs using the evidence-based methodology. A literature search was conducted using two electronic databases, Scopus, and PubMed. Risk of bias was assessed using the risk-ofbias assessment tool for non-randomized study version 2.0. A total of 158 articles were screened from the initial search and eventually, 5 articles were included in this systematic review. One study adopted both the longitudinal prospective cohort and case-control designs and other 4 articles adopted the cross-sectional design. Two studies employed polysomnography (PSG) for the diagnosis of OSA and mentioned the results from the PSG. All crosssectional studies demonstrated higher OSA prevalence among patients with TMD, and one cohort study suggested OSA as a risk factor for TMD. OSA appears to have potential influences on the development of TMD; however, the role of TMD in the development of OSA remains to be unknown owing to the lack of high-quality evidences.

“…Obstructive sleep apnea (OSA), the most prevalent chronic sleep-related breathing disorder is characterized by an intermittent or complete collapse of the upper airway during sleep with a reduction and/or cessation of airflow 1 . OSA has been associated with diverse comorbidities such as cognitive impairment, attention deficit, cardiovascular diseases, depression, and an increased risk of all-cause mortality 2 - 5 . Therefore, early diagnosis and prompt management of OSA are essential for reducing the risk of complications and their sequalae.…”

Section: Introductionmentioning

confidence: 99%

Does risk of obstructive sleep apnea have interaction with chronic facial pain?

Lee

2022

JKAOMS

Objectives:The main purpose of the present study was to investigate the associations between the risk of obstructive sleep apnea (OSA) and chronic orofacial pain in a nationally representative sample of the Korean population. Materials and Methods: Data from the 8th wave Korean national health and nutrition examination survey, which was conducted from 2019 to 2020 were analyzed. This study included 5,780 Koreans (2,503 males, 3,277 females) over 40 years of age. The presence of subjective chronic facial pain lasting more than 3 months was evaluated based on a self-reported questionnaire. The risk of OSA was determined using the STOP-BANG questionnaire. Data related to anthropometric and sociodemographic factors; diagnostic history of hypertension, depression, and OSA; level of health-related quality of life and stress awareness; health-related behaviors, including smoking and alcohol drinking; and sleep duration were collected. The participants were classified into two groups according to the presence of chronic facial pain. Results: The level of health-related quality of life and stress awareness showed significant differences between the two groups. The sleep duration on weekends also presented significant differences. No significant differences were observed in the presence of snoring and observed apnea, while participants with chronic facial pain showed significantly higher levels of tiredness between the groups. The risk of OSA evaluated by STOP-BANG questionnaire showed significant differences between groups; however, the risk of OSA seemed to be higher in participants without chronic facial pain. Conclusion:The participants with chronic facial pain demonstrated decreased sleep duration, lower health-related quality of life, and increased stress and tiredness. Even though, the role of OSA in the development of chronic facial pain was inconclusive from the study, it is possible that ethnicity play a role in relationship between OSA and chronic facial pain.