Association between Obesity and the Prevalence of Allergic Diseases, Atopy, and Bronchial Hyperresponsiveness in Korean Adolescents

Yoo, Sunmi; Kim, Hyo-Bin; Lee, So‐Yeon; Kim, Bong-Seung; Kim, Ja-Hyung; Yu, Jinho; Kim, Byung-Ju; Hong, Soo‐Jong

doi:10.1159/000319207

Cited by 53 publications

(50 citation statements)

References 58 publications

(51 reference statements)

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“…The explanation for this phenomenon may be found in the results of the study by Johnston et al (23) , who showed enhanced airway responsiveness with attenuation of airway inflammation in obese mice. These observations were confirmed by Yoo et al (24) , who indicated an increased bronchial hyperresponsiveness in obese patients. In addition, at the same time, obesity is associated with increased breathing effort, decreased physical activity and poorer skill performance, which could also cause the development and exacerbation of asthma.…”

Section: Discussionsupporting

confidence: 69%

Obesity – a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization

Sybilski

Raciborski²,

Lipiec³

et al. 2014

Public Health Nutr.

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Objective: To analyse the relationship between obesity and overweight and the prevalence of allergic diseases and sensitization, and the impact of gender and place of residence. Design: Questionnaire based on those used in ISAAC (International Study of Asthma and Allergies in Childhood) and ECRHS (European Community Respiratory Health Survey). Setting: Our study involved populations of the eight largest cities and one rural region in Poland (each with over 150 000 inhabitants). Subjects: The study included 18 617 participants (24·2 % aged 6-7 years, 25·4 % aged 13-14 years, 50·4 % adults aged 20-44 years) in eight cities and one rural area. The out-patient study involved 4783 patients (25·7 %); we performed skin prick testing with fifteen aeroallergens. Results: Overweight was found in 16·13 % of participants (9·11 % of 6-7-year-olds, 4·90 % of 13-14-year-olds and 25·61 % of adults), obesity in 6·41 % (7·16 %, 2·45 % and 8·36 %, respectively). In adults, overweight (OR = 1·34) and obesity (OR = 1·80) increased the prevalence of asthma, especially in women (OR = 1·53, OR = 2·01). Among 13-14-year-olds the prevalence was higher only in the obese (OR = 1·76). Overweight (OR = 1·99) and obesity (OR = 2·17) affected the incidence of doctordiagnosed asthma in 6-7-year-olds. Overweight (OR = 0·81) and obesity (OR = 0·76) reduced the prevalence of allergic rhinitis in men. There was no relationship between BMI and asthma in people from rural areas. Obesity and overweight did not affect the frequency of sensitization to aeroallergens. Conclusions: Overweight and obesity increased the prevalence of symptomatic asthma in adults, especially in women. In 13-14-year-olds, only obesity increased the prevalence of asthma. In children, overweight was associated with increased prevalence of clinically diagnosed and declared asthma and a trend towards atopy. Higher BMI was negatively associated with the prevalence of allergic rhinitis in overweight and obese man. There was no correlation between BMI and sensitization to aeroallergens.

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Section: Discussionsupporting

confidence: 69%

Obesity – a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization

Sybilski

Raciborski²,

Lipiec³

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

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“…Hong et al [68] have reported that high BMI is associated with an increased risk of asthma symptoms in boys. In addition, several studies have indicated an association of obesity with allergic rhinitis and atopic dermatitis in children and adolescents [6970]. …”

Section: Physical and Psychological Comorbiditiesmentioning

confidence: 99%

Epidemiology of Childhood Obesity in Korea

Kim

2016

Endocrinol Metab

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Over the past several decades, the prevalence of obesity has increased dramatically worldwide and is increasing not only in developed countries, but also in developing countries. This increase may lead to an increase in the incidence of chronic diseases throughout the lifespan. In Korean children and adolescents, the prevalence of obesity increased from 6.8% in 1998 to 10.0% in 2013. Obesity is a state that more commonly influences children and adolescents of lower socioeconomic status (SES) than those with a higher SES. However, the prevalence of metabolic syndrome in a nationally representative sample of Korean adolescents decreased from 1998 to 2012. According to the Diabetes Fact Sheet of the Korean Diabetes Association, the prevalence of type 2 diabetes among children aged 18 years or younger was 153.5 per 100,000 in 2006 and 205.0 per 100,000 in 2013. Obesity is a complex disease influenced by many interacting factors, such as adipocytokines, lipopolysaccharide-binding protein, adenovirus 36 infection, birth weight, lifestyle, and endocrine-disrupting chemicals. Obesity in youth can adversely impact practically every organ system and lead to serious consequences, such as metabolic, gastrointestinal, pulmonary, cardiovascular, and psychosocial complications. Therefore, coordinated efforts by governments, organizations, communities, and individuals are needed to prevent and treat childhood obesity. In particular, a long-term policy to improve the social environment will also be necessary.

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“…25 Nonetheless, the results are conflicting in the literature. Yoo et al 26 reported that overweight children were more likely to be atopic compared with children with a normal BMI. Atopy also was recently shown to significantly mediate the effect of adiposity on asthma outcomes in Puerto Rican children.…”

Section: Introductionmentioning

confidence: 99%