Association between obesity and lung function changes by sex and age in adults with asthma

Kim, Minji; Cho, Sang Heon; Jung, Jae-Woo; Choi, Byoung-Whui; Kim, Sae‐Hoon; Park, Hye Kyung; Jang, An‐Soo; Jin, Hyun Jung; Shin, Yoo Seob; Kim, Min-Hye; Lee, Jae-Hyun; Park, Jung-Won; Kwon, Jae-Woo; Lee, Taehoon; Kim, Solmi; Kim, Tae‐Bum; Choi, Jeong‐Hee

doi:10.1080/02770903.2020.1839904

Cited by 3 publications

(1 citation statement)

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“…This effect is most pronounced in the functional residual capacity (FRC) and expiratory reserve volume (ERV), while it has only small effects on the total lung capacity (TLC) [19,20,21,22 ▪ ]. During dynamic lung function tests, forced expiratory volume (FEV1) and forced vital capacity (FVC) are reduced while the FEV1/FVC ratio is usually unaffected [19,22 ▪ ,23–25]. However, in patients with comorbid metabolic syndrome, the FEV1/FVC ratio decreases because of increased abdominal circumference (which is a major criterion for metabolic syndrome and may influence airway diameter as well), greater tobacco exposure, and elevated eosinophils indicating low-grade systemic inflammation [26].…”

Section: Effects Of Obesity On Lung Functionmentioning

confidence: 99%

Obesity-related asthma: new insights leading to a different approach

Witte,

Türk,

Braunstahl

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Obesity is a growing global health threat that significantly contributes to the burden of asthma by increasing the risk of developing asthma and exerting a distinct effect on lung function and inflammation. The treatment of obesity-related asthma is hindered by a poor response to standard asthma treatments, leading to worse asthma control. Weight loss strategies have a significant effect on asthma symptoms but are not feasible for a large proportion of patients, underscoring the need for a better understanding of the pathophysiology and the development of additional treatment options. Recent findings Recent literature focusing on pathophysiology particularly delved into nontype 2 inflammatory mechanisms, associations with the metabolic syndrome and small airway impairment. Additionally, several new treatment options are currently investigated, including biologics, weight reduction interventions, and novel antiobesity drugs. Summary Obesity-related asthma is a highly prevalent asthma phenotype for which weight loss strategies currently stand as the most specific treatment. Furthermore, novel pharmacological interventions aiming at metabolic processes are on the way.

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Section: Effects Of Obesity On Lung Functionmentioning

confidence: 99%