Association between Obesity and Chronic Kidney Disease in Japanese: Differences in Gender and Hypertensive Status?

Ishizaka, Nobukazu; Ishizaka, Yuko; Toda, Etsuko; Koike, Kazuhiko; Seki, George; Nagai, Ryozo; Yamakado, Minoru

doi:10.1291/hypres.30.1059

Cited by 31 publications

(31 citation statements)

References 23 publications

(25 reference statements)

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“…To date, there are no reports on the effects of the combination of MetS and CKD on CVD occurrence. The influence of CKD on CVD incidence can reportedly be greater in men than in women (Ishizaka et al, 2007). A number of reports suggest that MetS, defined by NCEP-ATPIII criteria, as in our study, may influence the incidence of CVD, coronary heart disease in particular, in men relative to women (Qiao, 2006).…”

Section: Discussionsupporting

confidence: 49%

The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

Kotani

Satoh

Yamada

et al. 2010

J Physiol Anthropol

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Metabolic syndrome (MetS) and chronic kidney disease (CKD) are individual risk factors for cardiovascular disease (CVD). Abnormal hemorheology may be associated with CVD in both disorders. The present study investigated the impact of MetS and CKD on hemorheology. We studied 138 adults (women/menϭ63/75, mean ageϭ52.2 years), who included 87 participants with MetS and 33 with CKD. The hemorheology was assessed by the index of 'whole blood passage time (WBPT)' using the Micro Channel array Flow ANalyzer (MC-FAN). The WBPT values of MetS participants were significantly higher than those of non-MetS participants (52.5Ϯ13.1 vs. 46.3Ϯ7.7 sec, pϭ0.03). The WBPT values of CKD participants were significantly higher than those of non-CKD (55.5Ϯ12.7 vs. 48.6Ϯ11.0 sec, pϭ0.003). The significant influence of MetS and CKD on WBPT was qualified by their effect modification to WBPT (pϭ0.04). There was a significantly greater influence of the combination of MetS and CKD on WBPT (59.9Ϯ13.4 sec) in comparison to the influence of non-MetS and CKD (46.6Ϯ3.5) or non-CKD and MetS (50.0Ϯ12.2). The influence of the combination of MetS and CKD was clearer in men, relative to women. Abnormal hemorheology as assessed using MC-FAN may be enhanced by the combination of MetS and CKD.

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Section: Discussionsupporting

confidence: 49%

The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

Kotani

Satoh

Yamada

et al. 2010

J Physiol Anthropol

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“…This study showed a Several previous studies have shown that increased BMI is a risk factor for development of CKD. In a community-based cross-sectional study in Japan, Ishizaka et al found that increased BMI was associated with low eGFR only in men (13). The OR for developing new-onset kidney disease, defined as a GFR of less than 59.3 mL/min/1.73 m 2 in women and less than 64.3 mL/min/1.73 m 2 in men, was 23% (OR, 1.23; 95% CI, 1.08-1.41) for one SD increase in BMI (14).…”

Section: Discussionmentioning

confidence: 99%

An Association between Body Mass Index and Estimated Glomerular Filtration Rate

et al. 2008

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IntroductionThe increasing prevalence of chronic kidney disease (CKD), with its associated high annual rates of mortality and cardiovascular complications ( 1 -3 ), is a major public health problem. In Japan, clinical practice guidelines established by the Japanese Society of Nephrology estimate that 18.7% of adults have CKD, which is defined as kidney damage or glomerular filtration rate (GFR) < 60 mL/min/1.73 m 2 for 3 months or more regardless of cause ( 4 ), and 4.1% have moderate or severe CKD ( 5 ). Identifying risk factors for CKD is critical in order to devise effective, population-based preventive strategies. Obesity is also a major worldwide public health problem. Obesity increases the risk of cardiovascular disease, diabetes, hypertension, and dyslipidemia (6, 7). However, few studies have examined the relationship between excess weight and CKD risk. Obese patients are at a higher risk for focal segmental glomerulosclerosis and glomerulomegaly (8) Vol. 31, No. 8 (2008) (9). In Western countries, many patients have an estimated GFR (eGFR) of less than 60 mL/min/1.73 m 2 or a body mass index (BMI) of 30 kg/m 2 or more. However, the risk of slightly elevated weight (BMI, 22.0 to 24.9 kg/m 2 ) in a Japanese population for mildly reduced renal function (eGFR, 60 to 90 mL/min/1.73 m 2 ) is not clear. We evaluated the relationship of BMI to potential risk factors such as hypertension, hyperglycemia, and lipids, as well as to renal function, using cross-sectional data from community-dwelling participants. Methods SubjectsParticipants were recruited at the time of their annual health examination in a rural town that has a total population of 11,136 (as of April 2002) and located in Ehime Prefecture, Japan, in 2002. Among the 9,133 adults aged 19 to 90 years in this population, 3,164 (34.6%) subjects met the eligibility requirements to participate in the study. Information on medical history, present conditions, and drugs was obtained by interview. Subjects with a clinical history of stroke, transient ischemic attack, myocardial infarction, or angina were excluded. Subjects taking medications for hypertension, diabetes, or dyslipidemia were also excluded from the study. However, participants that met the eligibility requirements with BMI> 30 kg/m 2 were included (37 subjects). The final study sample included 1,716 eligible persons. All procedures were approved by the Ethics Committee of Ehime University School of Medicine. Evaluation of Risk FactorsWe measured blood pressure in the right upper arm of participants in a seated position using an automatic oscillometric blood pressure recorder. Cigarette smoking was quantified based on daily consumption and on duration of smoking. Fasting total cholesterol (T-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), creatinine (enzymatic method), and uric acid were measured during fasting. Low-density lipoprotein cholesterol (LDL-C) levels were calculated using the Friedewald formula (10). Participants with TG levels ≥ 4...

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“…The greater risk associated with male gender may be partly due to sex-related differences in the prevalence of hypertension (4,5) and/or dyslipidemia (6). Although the level of significance was not given, in a study of 8,168 Japanese subjects undergoing general health screening, the mean levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), low density lipoprotein (LDL), cholesterol, and triglyceride (TG) were all higher in men (n= 5,244) than in women (n= 2,924) (7). In that study, mean high density lipoprotein (HDL) cholesterol levels were lower in men than in women.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Y Chromosome on Cardiovascular Risk Factors in Japanese Men

et al. 2008

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Association between Obesity and Chronic Kidney Disease in Japanese: Differences in Gender and Hypertensive Status?

Abstract: Obesity is a known risk factor for hypertension and diabetes, both of which ultimately promote renal dysfunction. In the current study, we investigated the association between body mass index (BMI) and chronic

Cited by 31 publications

References 23 publications

The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

The Influence of Metabolic Syndrome and Chronic Kidney Disease on Hemorheology Assessed by the Microchannel Method

An Association between Body Mass Index and Estimated Glomerular Filtration Rate

Effects of the Y Chromosome on Cardiovascular Risk Factors in Japanese Men

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