“…However, after adjusting for H‐zone location in the multivariate analyses, the other indication criteria associated with three or more stages remained significant, indicating that H‐zone was not a confounder. Therefore, another explanation could be that the H‐zone, which includes embryonic fusion planes, offers a path of least resistance for the early development of vertical invasion and lateral spread of tumours located in this area, hereby enhancing the risk on extensive subclinical tumour spread 27,28 …”