Association between nonalcoholic fatty liver disease and cardiovascular disease revealed after comprehensive control of metabolic risk factors: a nationwide population-based study in Korea

Seo, B.S.; Roh, Jae‐Hyung; Lee, Jae‐Hwan; Lee, Hanbyul; Kim, Young Min; Yoon, Yong‐Hoon; Kim, Minsu; Kim, Yong-Giun; Park, Gyung‐Min; Park, Jae‐Hyeong; Seong, In‐Whan

doi:10.1097/meg.0000000000002102

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…One Korean study included 334,280 healthy subjects, and the fatty liver index was used to identify subjects with MAFLD. Interestingly, the study showed that healthy MAFLD patients progressed to develop CVD independently of the interim occurrence of other metabolic diseases [ 113 ]. In addition, the prevalence of steatosis and of severe fibrosis in an asymptomatic general adult population was estimated, and cardiovascular risk (CVR) was evaluated by atherosclerotic cardiovascular disease.…”

Section: Association Of Mafld and Nash With Cardiovascular Diseasesmentioning

confidence: 99%

Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases

Gutiérrez–Cuevas

Santos

Armendáriz‐Borunda

2021

IJMS

103

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Obesity is now a worldwide epidemic ensuing an increase in comorbidities’ prevalence, such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease (CVD), autoimmune diseases, and some cancers, CVD being one of the main causes of death in the world. Several studies provide evidence for an association between MAFLD and atherosclerosis and cardio-metabolic disorders, including CVDs such as coronary heart disease and stroke. Therefore, the combination of MAFLD/NASH is associated with vascular risk and CVD progression, but the underlying mechanisms linking MAFLD/NASH and CVD are still under investigation. Several underlying mechanisms may probably be involved, including hepatic/systemic insulin resistance, atherogenic dyslipidemia, hypertension, as well as pro-atherogenic, pro-coagulant, and pro-inflammatory mediators released from the steatotic/inflamed liver. MAFLD is strongly associated with insulin resistance, which is involved in its pathogenesis and progression to NASH. Insulin resistance is a major cardiovascular risk factor in subjects without diabetes. However, T2D has been considered the most common link between MAFLD/NASH and CVD. This review summarizes the evidence linking obesity with MAFLD, NASH, and CVD, considering the pathophysiological molecular mechanisms involved in these diseases. We also discuss the association of MAFLD and NASH with the development and progression of CVD, including structural and functional cardiac alterations, and pharmacological strategies to treat MAFLD/NASH and cardiovascular prevention.

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Section: Association Of Mafld and Nash With Cardiovascular Diseasesmentioning

confidence: 99%

Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases

Gutiérrez–Cuevas

Santos

Armendáriz‐Borunda

2021

IJMS

103

View full text Add to dashboard Cite

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“…A study population involving 334,280 healthy Korean subjects demonstrated that the incidence of CV events over a 5-year period was associated with the presence of NAFLD, diagnosed by the fatty liver index, independently of the presence of T2DM or hypertension (19). Similarly, in a small study including 78 non-diabetic and non-hypertensive patients attending the CV department for a coronagraphic assessment, NAFLD diagnosed by US, was associated with a 12-fold increased risk of having a coronary artery disease compared to non-NAFLD subjects (20).…”

Section: Introductionmentioning

confidence: 99%

Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension

Cattazzo

Lombardi

Mantovani

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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Impacts of Non-alcoholic Fatty Liver Disease on Acute Coronary Syndrome: Evidence and Controversies

Shi,

Jia,

Wang

et al. 2023

Curr Atheroscler Rep

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Purpose of Review Acute coronary syndrome (ACS) and non-alcoholic fatty liver disease (NAFLD) are two clinically common disease entities that share numerous risk factors. This review aimed to discuss the impacts of NAFLD on ACS. Recent Findings In an era of improved control of traditional risk factors, the substantial burden of cardiometabolic abnormalities has caused widespread concern. NAFLD is considered the hepatic component of metabolic syndrome, which can exert an impact on human health beyond the liver. Accumulating studies have demonstrated that NAFLD is closely related to cardiovascular disease, especially coronary artery disease. Interestingly, although recent data have suggested an association between NAFLD and the incidence and outcomes of ACS, the results are not consistent. Summary In this review, we comprehensively summarized evidence and controversies regarding whether NAFLD is a contributor to either the development of ACS or worse outcomes in patients with ACS. The potential pathophysiological and molecular mechanisms involved in the impacts of NAFLD on ACS were also elucidated.

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Association between nonalcoholic fatty liver disease and cardiovascular disease revealed after comprehensive control of metabolic risk factors: a nationwide population-based study in Korea

Abstract: Supplemental Digital Content is available in the text.

Cited by 4 publications

References 18 publications

Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases

Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases

Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension

Impacts of Non-alcoholic Fatty Liver Disease on Acute Coronary Syndrome: Evidence and Controversies

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