Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents

Alp, Hayrullah; Karaarslan, Sevim; Eklioğlu, Beray Selver; Atabek, Mehmet Emre; Altın, Hakan; Baysal, Tamer

doi:10.1016/j.cjca.2012.07.846

Cited by 46 publications

(43 citation statements)

References 30 publications

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“…To date, a number of case-control studies have demonstrated that nondiabetic patients with NAFLD, both adults and children/adolescents, have echocardiographic features of early LVDD compared with their counterparts without NAFLD [9,[31][32][33][34][35][36][37]. These myocardial functional abnormalities appear to be independent of multiple cardio-metabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Mantovani

Pernigo

Bergamini

et al. 2015

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Mantovani

Pernigo

Bergamini

et al. 2015

Digestive and Liver Disease

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“…Several studies show increased carotid intimamedia thickness in those with liver steatosis, 22,23 but others have showed that no relation was found with carotid intimamedia thickness or arterial wall stiffness. [24][25][26] Using magnetic resonance imaging to measure central aortic elastic function, we have shown here that hepatic fat is strongly associated with aortic PWV and with abdominal AD, both suggesting that liver fat plays a role in reducing aortic elastic function in children. The reasons behind the discrepancy in the literature may be that the majority of previous studies have recorded peripheral rather than central arterial elastic function.…”

Section: Nafld and Aortic Stiffness In Childrenmentioning

confidence: 99%

Investigating a Liver Fat

Rider

Banerjee

Rayner

et al. 2016

ATVB

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Circulating triglyceride levels are dictated not only by dietary intake but also by hepatic triglyceride production, which is elevated in NAFLD. This suggests that NAFLD may be exerting its negative effects on vascular function indirectly via increasing blood triglyceride levels. As a result, we hypothesized that the elevated liver fat levels in obesity would be linked to aortic stiffness, and that effect would, at least in part, be mediated indirectly via increasing serum triglyceride levels. Should © 2015 American Heart Association, Inc. Objective-To investigate the relationship between hepatic fat content, circulating triglyceride levels and aortic stiffness in adult and childhood obesity. Approach and Results-Seventy-seven adults and 18 children across a wide range of body mass index (18.5-52.6 kg/ m 2; percentile 8-100) with no identifiable cardiac risk factors underwent; 1H-magnetic resonance spectroscopy to quantify hepatic fat content and magnetic resonance imaging to assess aortic pulse wave velocity (PWV) and regional distensibility. In adults, multivariable regression showed age (β=0.09; P=0.02), liver fat (β=2.5; P=0.04), and serum triglyceride (β=0.47; P=0.01) to be independent predictors of PWV. Age and blood pressure-adjusted, moderated regression showed that 43% of the total negative effect of hepatic fat on PWV is attributable to indirect effects via increased triglyceride (P=0.005). In addition, regional distensibility was positively correlated with hepatic fat (ascending; r=−0.35; descending, r=−0.23; abdominal, r=−0.41; all P<0.001). Similar to that seen in adults, PWV (r=0.72; P<0.001) and abdominal regional distensibility (r=−0.52; P<0.001) were correlated with liver fat in children. Conclusions-Increasing age, liver fat, and triglyceride are all related to increased aortic stiffness in adults. Even when controlling for the effects of age and blood pressure, hepatic fat has a negative effect on PWV, with substantial indirect effect occurring via increased circulating triglyceride level. This relationship between hepatic fat and aortic stiffness occurs early in the obesity process and is also seen in children. As such, hepatic fat content is a potential therapeutic target to treat the elevated vascular risk in obesity. regional aortic distensibility (AD) 14 and abdominal visceral fat, 1H magnetic resonance spectroscopy assessment of liver fat content, dual-energy x-ray absorptiometry assessment of total fat mass, and fasting blood tests for serum triglyceride levels. Materials and MethodsMaterials and Methods are available in the online-only Data Supplement. ResultsA summary of the anthropometric data for the adult and childhood study groups is shown in Table 1. Table 3). Adult Cohort Hepatic Fat Content in AdultsStepwise multivariable regression of these variables revealed showed triglyceride (β=3.6; P=0.009) and liver fat (β=2.5; P=0.008) to be independent predictors of increased PWV in this model (overall R 2 of the model 0.42; P<0.001; Table 4). To further explore the relationship be...

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“…Atherosclerosis was found to be more common in children with fatty liver (30%) than in those without this abnormality (19%) [167,168] . Nonalcoholic fatty liver disease (NAFLD) is the most common of chronic liver disease in Western countries that affects about 20-30% of the general population and is closely related to oxidative stress and insulin resistance [164,[169][170][171] .…”

Section: T Gondii Expresses Two Ce-synthesizing Enzymes Tgacat1mentioning

confidence: 99%

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

Prandota

2017

Journal of Cardiology and Therapy

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Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents

Cited by 46 publications

References 30 publications

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Investigating a Liver Fat

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

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