Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

Jaiswal, Vikash; Ang, Song Peng; Huang, Helen; Momi, Navroop Kaur; Hameed, Maha; Naz, Sidra; Batra, Nitya; Ishak, Angela; Doshi, Neel; Gera, Asmita; Sharath, Medha; Waleed, Madeeha Subhan; Raj, Nishchita; Alvarez, Victor Hugo Aguilera

doi:10.1177/10815589231164777

Cited by 8 publications

(5 citation statements)

References 65 publications

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“…This meta-analysis was conducted and reported following the PRISMA (preferred reporting items for systematic review and meta-analysis) 2020 guidelines and performed according to established methods, as described previously [19][20][21][22].…”

Section: Methodsmentioning

confidence: 99%

Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis

Jaiswal,

Ang,

Deb

et al. 2024

Medicina

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Background: Chemotherapy-induced cardiac dysfunction (CIC) is a significant and concerning complication observed among cancer patients. Despite the demonstrated cardioprotective benefits of statins in various cardiovascular diseases, their effectiveness in mitigating CIC remains uncertain. Objective: This meta-analysis aims to comprehensively evaluate the potential cardioprotective role of statins in patients with CIC. Methods: A systematic literature search was conducted using PubMed, Embase, and Scopus databases to identify relevant articles published from inception until 10th May 2023. The outcomes were assessed using pooled odds ratio (OR) for categorical data and mean difference (MD) for continuous data, with corresponding 95% confidence intervals (95% CIs). Results: This meta-analysis comprised nine studies involving a total of 5532 patients, with 1904 in the statin group and 3628 in the non-statin group. The pooled analysis of primary outcome shows that patients who did not receive statin suffer a greater decline in the LVEF after chemotherapy compared to those who receive statin (MD, 3.55 (95%CI: 1.04–6.05), p = 0.01). Likewise, we observed a significantly higher final mean LVEF among chemotherapy patients with statin compared to the non-statin group of patients (MD, 2.08 (95%CI: 0.86–3.30), p > 0.001). Additionally, there was a lower risk of incident heart failure in the statin group compared to the non-statin group of patients (OR, 0.41 (95%CI: 0.27–0.62), p < 0.001). Lastly, the change in the mean difference for LVEDV was not statistically significant between the statin and non-statin groups (MD, 1.55 (95%CI: −5.22–8.33), p = 0.65). Conclusion: Among patients of CIC, statin use has shown cardioprotective benefits by improving left ventricular function and reducing the risk of heart failure.

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Section: Methodsmentioning

confidence: 99%

Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis

Jaiswal,

Ang,

Deb

et al. 2024

Medicina

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“…This meta-analysis was conducted and reported following the Cochrane and PRISMA (Preferred reporting items for systematic review and Meta-analysis) [32] and MOOSE (Meta-analysis of Observational Studies in Epidemiology) [33] guidelines and performed according to established methods, as described previously [34] , [35] , [36] . The pre-specified study protocol has been registered in the PROSPERO ( CRD42023410973) .…”

Section: Methodsmentioning

confidence: 99%

Cardioprotective effect of antiviral therapy among hepatitis C infected patients: A meta-analysis

Jaiswal,

Ang,

Hanif

et al. 2023

IJC Heart & Vasculature

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“…This meta-analysis was conducted and reported following the Cochrane and PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis) 2020 guidelines and performed according to established methods, as described previously. [15][16][17] The pre-specified study protocol has been registered in the PROSPERO (CRD42023424652).…”

Section: Me Thodsmentioning

confidence: 99%

Association between rheumatoid arthritis and atrial fibrillation: A systematic review and meta‐analysis

Jaiswal,

Roy,

Ang

et al. 2024

Journal of Arrhythmia

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Rheumatoid arthritis (RA) is an autoimmune disorder with a varying range of organs involved leading to adverse outcomes. However, very little is known, with conflicting results about the association between RA and atrial fibrillation (AF). We aim to evaluate the association between RA and AF, and other clinical outcomes. We performed a systematic literature search using PubMed, Embase, and Scopus for relevant articles from inception until September 10, 2023. Primary clinical outcomes were AF. Secondary outcomes were acute coronary syndrome (ACS), stroke, and all‐cause mortality (ACM). A total of 4 679 930 patients were included in the analysis, with 81 677 patients in the RA group and 4 493 993 patients in the nonrheumatoid arthritis (NRA) group. The mean age of the patients was 57.2 years. Pooled analysis of primary outcomes shows that RA groups of patients had a significantly higher risk of AF (odds ratios [OR], 1.53; 95% confidence interval [CI]: [1.16–2.03], p < .001) compared with NRA groups. Secondary Outcomes show that the RA group of patients had significantly higher odds of ACS (OR, 1.39; 95% CI: [1.26–1.52], p < .001), and ACM (OR, 1.19; 95% CI: [1.03–1.37], p = .02) compared with the NRA groups. However, the likelihood of stroke (OR, 1.02; 95% CI: [0.94–1.11], p = .61) was comparable between both groups of patients. Our study shows that RA groups of patients are at increased risk of having AF, ACS, and ACM.

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Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

Cited by 8 publications

References 65 publications

Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis

Association between Statin Use and Chemotherapy-Induced Cardiotoxicity: A Meta-Analysis

Cardioprotective effect of antiviral therapy among hepatitis C infected patients: A meta-analysis

Association between rheumatoid arthritis and atrial fibrillation: A systematic review and meta‐analysis

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