Association between nocturnal/supine hypertension and restless legs syndrome in patients with Parkinson's disease

Oh, Yoon‐Sang; Kim, Joong‐Seok; Park, In-Seok; Song, In‐Uk; Son, Young-Min; Park, Jeong‐Wook; Yang, Dong-Won; Kim, Hee-Tae; Lee, Kwang‐Soo

doi:10.1016/j.jns.2014.06.056

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…Non‐motor PD symptoms such as sleep complaints, fatigue, lower quality of life, poor cognition, depression and autonomic dysfunctions seem to be increased in PD patients displaying RLS (Neikrug et al., ; Oh et al., ).…”

Section: Resultsmentioning

confidence: 99%

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An overview of sleep and circadian dysfunction in Parkinson's disease

Mantovani

Smith

Gordon

et al. 2018

Journal of Sleep Research

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Sleep and circadian alterations are amongst the very first symptoms experienced in Parkinson's disease, and sleep alterations are present in the majority of patients with overt clinical manifestation of Parkinson's disease. However, the magnitude of sleep and circadian dysfunction in Parkinson's disease, and its influence on the pathophysiology of Parkinson's disease remains often unclear and a matter of debate. In particular, the confounding influences of dopaminergic therapy on sleep and circadian dysfunction are a major challenge, and need to be more carefully addressed in clinical studies. The scope of this narrative review is to summarise the current knowledge around both sleep and circadian alterations in Parkinson's disease. We provide an overview on the frequency of excessive daytime sleepiness, insomnia, restless legs, obstructive apnea and nocturia in Parkinson's disease, as well as addressing sleep structure, rapid eye movement sleep behaviour disorder and circadian features in Parkinson's disease. Sleep and circadian disorders have been linked to pathological conditions that are often co-morbid in Parkinson's disease, including cognitive decline, memory impairment and neurodegeneration. Therefore, targeting sleep and circadian alterations could be one of the earliest and most promising opportunities to slow disease progression. We hope that this review will contribute to advance the discussion and inform new research efforts to progress our knowledge in this field.

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Section: Resultsmentioning

confidence: 99%

“…| 9 of 22 dysfunctions seem to be increased in PD patients displaying RLS (Neikrug et al, 2013;Oh et al, 2014).…”

Section: Restless Legs Syndrome and Periodic Leg Movementsmentioning

confidence: 96%

An overview of sleep and circadian dysfunction in Parkinson's disease

Mantovani

Smith

Gordon

et al. 2018

Journal of Sleep Research

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“…24-hour ambulatory BP monitoring reveals significant differences in the rhythm of non-dipping, the percent of nocturnal BP decrease, nighttime BP levels, and nocturnal decrease of HR between PD patients and controls[347]. These changes do not appear related to disease severity and phenotype, supporting the hypothesis that these alterations may stem from intrinsic circadian dysregulation.…”

Section: Circadian Rhythms Disruptionmentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

262

249

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Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

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“…These abnormalities are associated with various nonmotor features such as cognitive impairment, dementia, depression, and sleep problems 30313233. These dysfunctions in PD are related to cardiac and extracardiac neuronal degeneration and the α-synuclein-related Braak pathological sequence 3435…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism

Kim

Ryu

et al. 2017

J Clin Neurol

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Background and PurposeRecent studies have shown that several nonmotor symptoms differ between Parkinson's disease (PD) and drug-induced parkinsonism (DIP). However, there have been no reports on cardiovascular autonomic function in DIP, and so this study investigated whether cardiovascular autonomic function differs between PD and DIP patients.MethodsThis study consecutively enrolled 20 DIP patients, 99 drug-naïve PD patients, and 25 age-matched healthy controls who underwent head-up tilt-table testing and 24-h ambulatory blood pressure monitoring.ResultsOrthostatic hypotension was more frequent in patients with PD or DIP than in healthy controls. In DIP, orthostatic hypotension was associated with the underlying psychiatric diseases and neuroleptics use, whereas prokinetics were not related to orthostatic hypotension. The supine blood pressure, nighttime blood pressure, and nocturnal blood pressure dipping did not differ significantly between the DIP and control groups. Supine hypertension and nocturnal hypertension were more frequent in PD patients than in controls.ConclusionsThe included DIP patients frequently exhibited orthostatic hypotension that was associated with the underlying diseases as well as the nature of and exposure time to the offending drugs. Clinicians should individualize the manifestations of DIP according to underlying diseases as well as the action mechanism of and exposure time to each offending drug.

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Association between nocturnal/supine hypertension and restless legs syndrome in patients with Parkinson's disease

Cited by 34 publications

References 29 publications

An overview of sleep and circadian dysfunction in Parkinson's disease

An overview of sleep and circadian dysfunction in Parkinson's disease

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism

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