Association between nocturia and anxiety in Parkinson's disease

Rana, Abdul Qayyum; Paul, Dion A.; Qureshi, Abdul-Rehman M; Ghazi, Abdullah; Alenezi, Shuliweeh; Rana, M. A. A.; Moazen, M; Akhter, Sadaf; Owlia, Aida; Akhter, Mohammad; Randhawa, Shahroz; moosavi, zahra

doi:10.1179/1743132815y.0000000010

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Several specific nonmotor symptoms are also known to be associated with LUT dysfunction [30, 31]. Our results suggested a possible connection between RBD and LUT dysfunction in PD.…”

Section: Discussionsupporting

confidence: 58%

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson’s Disease Patients

Han

Wang

et al. 2019

Parkinson's Disease

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Background. Lower urinary tract (LUT) dysfunction is very common in Parkinson’s disease (PD) patients. However, the number of studies conducted on LUT dysfunction and its related factors in Chinese PD patients is very limited, and there is no international consensus concerning the results. Methods. This cross-sectional study enrolled 100 Chinese PD patients. The patients were classified based on their overactive bladder symptom score (OABSS) and then assigned to either a PD with overactive bladder (PD-OAB) group or a PD with no overactive bladder (PD-NOAB) group. A binary logistic regression analysis was performed to identify the accompanying factors for overactive bladder (OAB). Next, correlations between the OABSS and patient sex, age, age of onset, disease duration, MDS-UPDRS-III, H-Y stage, PD subtype, treatment, education, and nonmotor symptoms were analyzed to identify factors correlated with LUT dysfunction. Results. Eighty nine (89%) of the PD patients suffered from LUT dysfunction, and OAB was diagnosed in 45 (45%) of those PD patients. The most common lower urinary tract (LUT) symptom in the PD patients was nighttime frequency (86%), followed by urgency (50%), urge incontinence (34%), and daytime frequency (17%). Patients in the PD-OAB group had an older age and age of onset, were at a more advanced Hoehn–Yahr stage, and had more severe motor symptoms and nonmotor symptoms, including worse cognition, and a greater incidence of REM sleep behavior disorder (RBD). A binary logistic regression analysis showed that a lower Frontal Assessment Battery (FAB) score, higher H-Y stage, and RBD accompanied with a higher prevalence of OAB in PD patients. A multiple linear regression analysis showed that the OABSS was significantly influenced by the FAB score, H-Y stage, RBD, and age. Conclusions. The FAB score, H-Y stage, and RBD are accompanying factors for OAB. A higher OABSS in PD patients was related to a lower FAB score for frontal lobe executive dysfunction, a higher H-Y stage for severity of motor disorders, RBD, and an older age.

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“…Several specific nonmotor symptoms are also known to be associated with LUT dysfunction [30, 31]. Our results suggested a possible connection between RBD and LUT dysfunction in PD.…”

Section: Discussionsupporting

confidence: 58%

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson’s Disease Patients

Han

Wang

et al. 2019

Parkinson's Disease

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“…Yeo et al 20 described nocturia as the most common urinary tract complaint in patients with PD (>60%) and attributed it to detrusor muscle overactivity, while urgency was found at 33%–54%. Rana et al 21 reported a significant association between anxiety and nocturia in patients with PD, with greater significance found for male patients as compared with female patients, and suggested that addressing anxiety may help nocturia.…”

Section: Discussionmentioning

confidence: 99%

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

et al. 2018

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ObjectiveTo determine the frequency of non-motor symptoms (NMS) in patients of Parkinson’s disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients.Study designObservational, cross-sectional study.SettingTertiary care centre.ParticipantsOut of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions. Exclusion criteria were diseases that resemble PD, stroke, dementia, patients unable to provide information and history of antipsychotic use.ResultsThe NMSQuest revealed a mean of nearly seven different NMS per patient. Autonomic problems such as constipation (56%) and nocturia (49%) were the most common NMS, while urinary urgency was reported by 35% of patients. Low mood and feeling sad were reported by 47%, whereas feeling anxious/panicky was reported by 36%. Problem with memory was reported by 45% of patients. Feeling of light-headedness and dizziness was reported by 40% of patients. Problems with sexual relationship were reported by 30% of patients. The most common sleep problem was difficulty falling sleep (29%). Pain not related to the musculoskeletal system was reported by 30% of patients. Loss or change in the ability to taste or smell was reported by 29% of patients. The rest of NMS were less than 25% in frequency. Feeling sad or blue, feeling light-headed/dizzy, unexplained pain, unpleasant sensations in the legs, difficulty in swallowing and faecal incontinence were more common in female participants, while problems with sex were more common in male participants.ConclusionNMS are quite prevalent in PD in our population. Certain NMS are more common in women as compared with men. There is a need for a large-scale study to look for the association of different NMS with sex.

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“…One study in which 314 PwPD were enrolled reported a significant association between nocturia and anxiety, which was more prominent in male patients. The authors suggest that multiple instances of awakening during the night due to the need to void induce a state of distress for these patients, and contribute to a vicious circle in which nocturia, anxiety, interrupted and inadequate sleep, and fear of falling are involved [54]. According to Benli et al, lower urinary dysfunction may be a risk factor for the development of anxiety and depression [55].…”

Section: Discussionmentioning

confidence: 99%

Nocturia and Sleep in Parkinson’s Disease

Diaconu

Irincu

Ungureanu

et al. 2023

JPM

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Background: Nocturia has a high prevalence in Parkinson’s Disease (PD) and is known to be a bothersome symptom for people with Parkinson’s disease (PwPD). Objective: to characterize nocturia in a sample of PwPD, in relation to sleep, fatigue and other non-motor symptoms (NMS). Methods: we assessed 130 PwPD using a comprehensive battery of scales, which includes the Non-Motor Symptoms Questionnaire (NMSQ), International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), Parkinson’s Disease Sleep Scale version 2 (PDSS-2), Parkinson’s Disease Questionnaire (PDQ-39), The Overactive Bladder Questionnaire-Short form (OABq-SF), and the Parkinson’s Fatigue Scale (PFS-16). Results: according to the positive answers to the item of the NMSQ related to nocturia, patients were divided into PwPD + nocturia, and PwPD − nocturia. Nocturia was reported by 112 patients (86.15%). Quality of life in PwPD + nocturia was worse than in PwPD − nocturia, according to the PDQ-39 scores (13.32 ± 9.00 vs. 26.29 ± 14.55, p < 0.001). Sleep was significantly disturbed in PwPD + nocturia compared to PwPD − nocturia, according to the total scores of various scales, such as PDSS-2, PFS-16. PwPD who complained of nocturia presented higher scores of several NMS. Conclusions: nocturia has a high prevalence in PwPD and it is associated with impaired sleep, fatigue, and reduced quality of life.

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Association between nocturia and anxiety in Parkinson's disease

Abstract: Based on these findings, we can conclude that anxiety and nocturia are not entirely independent symptoms in all PD patients. Thus, addressing anxiety may improve nocturia in PD or vice versa.

Cited by 10 publications

References 19 publications

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson’s Disease Patients

Relationship between Lower Urinary Tract Dysfunction and Clinical Features in Chinese Parkinson’s Disease Patients

Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study

Nocturia and Sleep in Parkinson’s Disease

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