Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese

Abstract

Molecular heterogeneity of neuropeptide Y (NPY) and its three receptors (1, 2 and 5) has recently been discovered. NPY2R polymorphisms have been shown to be related to cocaine and alcohol dependence in European Americans. To test our hypothesis that these polymorphisms influence the smoking behavior of Japanese population, we investigated the prevalence of the rs4425326 and rs6857715 polymorphisms, which have been suggested to be related to alcohol dependence in European Americans, in 2517 Japanese elderly subjects for whom information on smoking behaviors was available. The prevalence of current smokers was greater among Japanese men having the rs4425326 C allele than ex-smokers. Among the ever-smokers, the Fagerström Test for Nicotine Dependence scores were higher in men having the rs4425326 homozygous T allelotype, and the numbers of cigarettes smoked per day were also significantly higher in the male smokers having the TT genotype. No correlations between the Tobacco Dependence Screener scores and any genotypes were detected. These results suggest that rs4425326 polymorphism may be related to smoking behavior in the Japanese elderly population. This study for the first time suggests NPY2R genotype as a possible genetic factor in nicotine dependence.

Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderly Japanese

“…The age, sex and smoking status of the participants have been reported previously 14 and are shown in Table 1. The age of participants whose DNA could be genotyped ranged from 60 to 94, with the mean age for males being 73.1 years and for females being 73.0 years.…”

“…The overall portraits of subjects have been described previously. 14 The participants were required to fill in a questionnaire leaflet containing various questions about lifestyle, including alcohol consumption, smoking, diet and cancer history. They were assisted in filling out the leaflet by professional interviewers.…”

Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

“…The inclusion criteria for this study were being ambulatory, able to communicate orally, and 60 years of age or older. Numerous participants in this study had various smoking habits and completed a questionnaire that consisted of various questions about lifestyle, including alcohol consumption, smoking, diet, and cancer history (37). Peripheral blood samples were collected from these subjects for the gene analysis.…”

Development of Novel Pharmacotherapeutics for Tobacco Dependence: Progress and Future Directions

“…Finally, GWAS has identified genomic loci not involved in coding for nAChR subunits that may play a role in risk of tobacco dependence and as such may be suitable for the development of novel therapeutics. For example, polymorphisms in the galanin 1 receptor (Lori et al, 2011), 5-HT2A and 2C receptors (Iordanidou et al, 2010;Polina, Contini, Hutz, & Bau, 2009;White, Young, Morris, & Lawford, 2011), neuropeptide Y (NPY), Y2 receptor (Sato et al, 2010), catechol-O-methyltransferase (COMT) (Nedic et al, 2010), Rho GTPases (Chen et al, 2007;Lind et al, 2010), muscarinic receptors 2 and 5 (Anney et al, 2007;Mobascher et al, 2010), brain-derived neurotropic factor and its receptor (TrkB) (Amos, Spitz, & Cinciripini, 2010; "Genomewide meta-analyses identify multiple loci associated with smoking behavior, " 2010; Li, Lou, Chen, Ma, & Elston, 2008;Vink et al, 2009), neuroexin-1 (Nussbaum et al, 2008), CYP2A6 and CYP2B6 (Nakajima, 2007;Ring et al, 2007;Sellers, Tyndale, & Fernandes, 2003;Thorgeirsson et al, 2010), β-arrestin 1 and 2 (Sun, Ma, Payne, & Li, 2008), phosphatase and tensin homolog gene (Zhang, Kendler, & Chen, 2006), and GABA-B receptors (Li et al, 2009) are all associated with nicotine dependence. These findings suggest that observations made in the human genetics literature identifying genes influencing vulnerability to tobacco dependence may be leveraged for future medications development.…”