Association Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction

Bozkurt, Mehtap; Göçmez, Cüneyt; Söylemez, Haluk; Dağgülli, Mansur; Em, Serda; Yıldız, Mehmet; Atar, Murat; Bozkurt, Yasar; Özbey, İsa

doi:10.1111/jsm.12458

Cited by 12 publications

(3 citation statements)

References 31 publications

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“…35 Serotoninspecific reuptake inhibitors and serotonin norepinephrine reuptake inhibitors used to treat pain and depression can cause desire, arousal, and orgasmic dysfunction in able-bodied men and women 36 ; in persons with SCI with complaints of sexual dysfunction, it may be appropriate to wean them off of these medications or to add or switch to an antidepressant with fewer negative sexual side effects (such as buproprion or mirtazapine). The antiepileptic drugs pregabalin 37 and gabapentin, 38 which are often used to treat chronic neuropathic pain, are linked to sexual dysfunction. Moreover, baclofen, which is commonly used to treat spasticity, is known to cause arousal and orgasmic dysfunction.…”

Section: Treating Confounding Issuesmentioning

confidence: 99%

Improving Sexual Satisfaction in Persons with Spinal Cord Injuries: Collective Wisdom

Alexander

Courtois

Elliott

et al. 2017

Topics in Spinal Cord Injury Rehabilitation

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Sexuality is an important part of life, and it is necessary for clinicians to have a specific format in which to address sexual issues with their patients. A systematic approach to working with patients with spinal cord injury (SCI) to improve their sexual functioning and response is presented. Nonjudgmental communication about sexual concerns is followed by a detailed pre-and postinjury medical, psychosocial, and sexual history. If preexisting sexual issues are present, it is recommended that the patient be referred for assessment and treatment of these separate from the patient's SCI-related concerns. Physical examination, with special attention to issues that could impact the patient's sexuality, is followed by a detailed neurologic assessment with specific attention to the T11-L2 and S3-5 spinal segments. Education of the patient with regard to his or her sexual potential and the need to be flexible in his or her sexual repertoire is followed by self-exploration and practice. Routine follow-up is suggested after patient's initial sexual exploration. Treatment of confounding and iatrogenic factors related to SCI is followed by more sexual experience. Afterwards the clinician is encouraged to use simple techniques to treat sexual issues and follow-up with the patient to assess the outcome. A structured program utilizing vibratory stimulation with or without midodrine is described as a way to achieve ejaculation and potentially orgasm, and techniques for treating severe autonomic dysreflexia are discussed. If these interventions do not alleviate the patient's sexual concerns, the clinician should refer the patient for more specialized consultation.

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Section: Treating Confounding Issuesmentioning

confidence: 99%

Improving Sexual Satisfaction in Persons with Spinal Cord Injuries: Collective Wisdom

Alexander

Courtois

Elliott

et al. 2017

Topics in Spinal Cord Injury Rehabilitation

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“…Erectile dysfunction could be because of several reasons including vascular dysfunction, endocrine disturbance, psychogenic or medicine related. 13 In our study, close to one fourth patients had psychogenic erectile dysfunction. It is quite possible that while looking for organic causes clinicians might ignore the psychological factors.…”

Section: Discussionmentioning

confidence: 99%

Use of neuro-psychiatry medicines in patients with sexual dysfunction: a retrospective study

Mutha

Kulkarni

Beldar

et al. 2017

Int J Basic Clin Pharmacol

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Background: The objective of the study was to understand the usage of neuro-psychiatry medicines in patients presenting with symptoms of sexual dysfunction.Methods: Medical records of adult patients consulting in the clinic out patients with symptoms of sexual dysfunction were screened for prescriptions of neuropsychiatry medicines. Common neuropsychiatric co-morbidities and prevalence of usage of medicines used for treating neuro-psychiatric disorders was calculated.Results: A total of 628 patients with sexual disorders were included of which 57 (9.1%) had received at least one neuro-psychiatry medicine at the time of presentation. Three most common sexual problems were unconsummated marriage 16 (28.1%), psychogenic ED 14 (24.6%) and organic erectile dysfunction 8 (14.0%). A total of erectile dysfunction 46 (7.3%) patients had psychiatric comorbidity. Five most common neuropsychiatric co-morbidities were anxiety 14 (30.4%), schizhophrenia 10 (21.7%), stress 7 (15.2%), depression 6 (13.0%) and epilepsy 2 (4.3%). The most commonly used neuro-psychiatry medicines were fluoxetine 15 (19.7%), risperidone 11 (14.5%), clonazepam 10 (13.2%), escitalopram 9 (11.8%), alprazolam 5 (6.6%), olanzapine 5 (6.6%) and gabapentin 4 (5.3%). Amisulpride was used in 3 (3.9%) patients whereas valproate, fluoxamine, diazepam and paroxetine were used in 2 (2.6%) patients each. Phenytoin, imipramine, carbamazepine, venlafaxine, haloperidol and sertarline were used in one patient each.Conclusions: Anxiety, schizophrenia and depression are the most common neuropsychiatric disorders in patients with sexual dysfunction. Many patients presenting with sexual dysfunction are already on neuropsychiatry medicines. Further studies are required to evaluate the association between neuropsychiatry medicines and sexual dysfunction in Indian patients.

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“…A study comparing sexual function in men with neuropathic pain who were taking pregabalin and those who were not [25] found that although erectile dysfunction was worse with pregabalin, there was no significant difference between the two groups in terms of sexual desire. The loss of desire experienced by these patients is more likely, therefore, to be associated with the psychiatric complications of the condition, namely depression, anxiety and sleep disorders.…”

Section: Organic Loss Of Sexual Desirementioning

confidence: 95%

Sex drive and sexual desire

Holloway

Wylie

2015

Current Opinion in Psychiatry

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Association Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction

Cited by 12 publications

References 31 publications

Improving Sexual Satisfaction in Persons with Spinal Cord Injuries: Collective Wisdom

Improving Sexual Satisfaction in Persons with Spinal Cord Injuries: Collective Wisdom

Use of neuro-psychiatry medicines in patients with sexual dysfunction: a retrospective study

Sex drive and sexual desire

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