Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real‐life experience

Rabat, Yolaine; Houeze, Richard; Sagnier, Sharmila; Olindo, Stéphane; Poli, Mathilde; Debruxelles, Sabrina; Renou, Pauline; Rouanet, François; Berthoz, Sylvie; Sibon, Igor

doi:10.1002/brb3.2158

Cited by 6 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Introduced by Alexopoulos et al [ 27 ], it proposed that cerebral small vessel disease (CSVD), in particular subcortical microvascular dysfunction and white matter hyperintensities (WMH), microbleeds and lacunes in gray matter, may predispose, precipitate, and perpetuate depressive symptoms in aged people as a consequence of structural damage in the fronto–subcortical circuits [ 23 , 27 , 28 ]. This hypothesis is based on the observation that cerebrovascular risk factors are frequently present in aged individuals with depression, its comorbidity with cerebrovascular lesions, and the frequent development of depression after stroke, affecting between 20% and 30% of all stroke patients [ 29 , 30 , 31 ]. Cerebrovascular burden in midlife predicts depressive symptomatology in later life, suggesting an interrelation between cerebrovascular burden and LLD [ 32 ].…”

Section: The “Vascular Depression Hypothesis”mentioning

confidence: 99%

Pathomechanisms of Vascular Depression in Older Adults

Jellinger¹

2021

IJMS

View full text Add to dashboard Cite

Depression in older individuals is a common complex mood disorder with high comorbidity of both psychiatric and physical diseases, associated with high disability, cognitive decline, and increased mortality The factors predicting the risk of late-life depression (LLD) are incompletely understood. The reciprocal relationship of depressive disorder and age- and disease-related processes has generated pathogenic hypotheses and provided various treatment options. The heterogeneity of depression complicates research into the underlying pathogenic cascade, and factors involved in LLD considerably differ from those involved in early life depression. Evidence suggests that a variety of vascular mechanisms, in particular cerebral small vessel disease, generalized microvascular, and endothelial dysfunction, as well as metabolic risk factors, including diabetes, and inflammation that may induce subcortical white and gray matter lesions by compromising fronto–limbic and other important neuronal networks, may contribute to the development of LLD. The “vascular depression” hypothesis postulates that cerebrovascular disease or vascular risk factors can predispose, precipitate, and perpetuate geriatric depression syndromes, based on their comorbidity with cerebrovascular lesions and the frequent development of depression after stroke. Vascular burden is associated with cognitive deficits and a specific form of LLD, vascular depression, which is marked by decreased white matter integrity, executive dysfunction, functional disability, and poorer response to antidepressive therapy than major depressive disorder without vascular risk factors. Other pathogenic factors of LLD, such as neurodegeneration or neuroimmune regulatory dysmechanisms, are briefly discussed. Treatment planning should consider a modest response of LLD to antidepressants, while vascular and metabolic factors may provide promising targets for its successful prevention and treatment. However, their effectiveness needs further investigation, and intervention studies are needed to assess which interventions are appropriate and effective in clinical practice.

show abstract

Section: The “Vascular Depression Hypothesis”mentioning

confidence: 99%

Pathomechanisms of Vascular Depression in Older Adults

Jellinger¹

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Finally, and perhaps most significantly, the findings of this study supported the CSM's (Walker et al, 2009 ) theoretical framework and complemented the significance of perceived recurrence risk and coping mechanisms in individual health outcomes. Stroke is a chronic and dynamic disease (Rabat et al, 2021 ). It is critical that stroke survivors view the chance of recurrence favourably.…”

Section: Discussionmentioning

confidence: 99%

“…PSD, one of the most frequent stroke consequences (Shi et al, 2017 ), may have a negative impact on the course of stroke survivors. PSD has been proven to impair the recovery of motor and cognitive function in several studies, which lowers the quality of life for stroke survivors and raises the risk of recurrence and mortality (Lu et al, 2019 ; Rabat et al, 2021 ). According to Ge et al ( 2014 ), PSD is more common in rural areas due to the subjective characteristics of stroke survivors and objective aspects of the environment (Zemed et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between perceptions of recurrence risk and depression state among first‐episode ischemic stroke patients in rural areas: The mediating role of coping style

et al. 2023

View full text Add to dashboard Cite

Aims To investigate the relationship between stroke survivors' perceptions of recurrence risk, coping styles and depression state, and the role coping styles play in mediating that relationship. Design A cross‐sectional descriptive study. Methods From one hospital in Huaxian, China, 320 stroke survivors were randomly selected as a convenience sample. In this research, the Simplified Coping Style Questionnaire, the Patient Health Questionnaire‐9 and the Stroke Recurrence Risk Perception Scale were all used. Structural equation modelling and correlation analysis were used to analyse the data. This research followed the EQUATOR and STROBE checklists. Results There were 278 valid survey responses. There were mild to severe depressive symptoms in 84.8% of stroke survivors. In stroke survivors, there was a significant negative relationship (p < 0.01) between the positive coping of perceptions of recurrence risk and their depression state. Recurrence risk perception's impact on depression state was partly mediated, according to mediation studies, by coping style, with the mediation effect accounting for 44.92% of the overall effect. Conclusions The connection between perceptions of recurrence risk and depression state was mediated by the coping mechanisms of stroke survivors. A lower degree of depression state among survivors was connected with positive coping to the beliefs of recurrence risk.

show abstract

“…It may be due to a common inflammatory and vascular factor underlying stroke, AD, and for example depression 27 . Stroke can also cause or be a trigger for depression 28 . Asthma/COPD was slightly associated with belonging to the Prodromal group.…”

Section: Discussionmentioning

confidence: 99%

“…27 Stroke can also cause or be a trigger for depression. 28 Asthma/COPD was slightly associated with belonging to the Prodromal group. Previous studies have shown that hypoxemia correlates with neuropsychological impairment.…”

Section: Other Characteristics Associated With Belonging To the Prodr...mentioning

confidence: 92%

Prevalence and characteristics of psychiatric morbidity treated in specialized health care in a nationwide cohort of people with newly diagnosed Alzheimer's disease

Alastalo

Tolppanen

Nietola

et al. 2022

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real‐life experience

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 37 publications

Pathomechanisms of Vascular Depression in Older Adults

Pathomechanisms of Vascular Depression in Older Adults

Relationship between perceptions of recurrence risk and depression state among first‐episode ischemic stroke patients in rural areas: The mediating role of coping style

Prevalence and characteristics of psychiatric morbidity treated in specialized health care in a nationwide cohort of people with newly diagnosed Alzheimer's disease

Contact Info

Product

Resources

About