Association between neonatal serum bilirubin and childhood obesity in preterm infants

Luo, Lijuan; Zou, Lile; Dong, Wei; He, Yuan; Yu, Huiyang; Lei, Xiaoping

doi:10.1038/s41390-019-0399-3

Cited by 5 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physiological jaundice is very common in newborns presenting much higher serum bilirubin concentrations than any other normal population. However, inconsistent with the previous studies on this topic 13–19 , our previous study demonstrated that neonatal bilirubin concentrations positively associated with childhood obesity among preterm infants 21 . So the question rise whether term-newborns with hyperbilirubinemia has the same associations with obesity in later life?…”

Section: Introductioncontrasting

confidence: 88%

“…As described in our previous study 21 , perinatal factors were chosen as potential confounders: maternal characteristics included age at delivery (<20, 25–35, and >35 years), marital status (married, unmarried, and other), highest maternal education (<10th, 10th −12th, and >12th grades), maternal smoking (0, 1–19 and 20 cigarettes per day during pregnancy), hypertensive disorders during pregnancy (none, moderate, and severe), socioeconomic status (comprised of 5 categories as assessed by the original CPP investigators) and maternal pregnancy BMI (<18, 18–25, >25), BMI gain during pregnancy (<3, 3–6, >6). Infant characteristics included race (white, black, and other race); sex (male and female); gestational age (as categorical variable), delivery method (vaginal, cesarean section and others), birthweight (<2500 g, 2500g-4000g, and >4000 g); and feeding method (exclusively breast, exclusively bottle, mixed feeding, and unknown).…”

Section: Methodsmentioning

confidence: 97%

See 1 more Smart Citation

Associations between Neonatal Serum Bilirubin and Childhood Obesity in Term Infants

Zou

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

Inverse correlations between serum bilirubin level and obesity had been reported in adults. We aimed to investigate the associations between neonatal hyperbilirubinemia and childhood obesity. Data was obtained from the U.S. Collaborative Perinatal Project (CPP), a multicenter study from 1959 to 1976. Data of serum bilirubin in term newborns were used to observe the association with obesity at age of 7 years. Logistic regression models were performed to calculate adjusted odds ratios (aORs) for obesity. For children from the same mother sharing similar factors, Generalized Estimating Equation (GEE) model was used to correct for intracluster correlation. Relative to newborns with total serum bilirubin (TSB) < 3 mg/dl, there are lower risks for obesity in those with 3 mg/dl ≤ TSB < 6 mg/dl (aOR 0.91; 95%CI 0.81, 1.02), 6 mg/dl ≤ TSB < 9 mg/dl (aOR 0.88; 95%CI 0.78, 0.99), 9 mg/dl ≤ TSB<13 mg/dl (aOR 0.83; 95%CI 0.71, 0.98). By stratifying for subtypes of bilirubin, the inverse correlations only existed in exposure to unconjugated bilirubin. By using the GEE model correcting for intracluster correlations, the results are consistent. In summary, exposure to bilirubin up to 13 mg/dl is inversely associated with obesity at the age of 7 years in term infants.

show abstract

Section: Introductioncontrasting

confidence: 88%

Section: Methodsmentioning

confidence: 97%

Associations between Neonatal Serum Bilirubin and Childhood Obesity in Term Infants

Zou

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neonatal bilirubin levels had a positive trend of association with childhood obesity in preterm infants. However, the data collected was completed over 50 years ago and may not reflect the current trend of obesity and is the main limitation of this study [5].…”

Section: Figure 1: Hypothalamic Pituitary Adrenal Axis Dysfunction Promoting Obesitymentioning

confidence: 99%

“…A large prospective birth cohort was carried out over seven years, and the trend that was observed is higher the level of neonatal serum bilirubin, the higher the risk of childhood obesity [5]. The underlying mechanism suggested is that exposure to extreme levels of bilirubin results in neurotoxicity leading to more neurodevelopmental disabilities.…”

Section: Neonatal Serum Bilirubin In Premature Infants Leading To Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Prematurity and the Risk of Development of Childhood Obesity: Piecing Together the Pathophysiological Puzzle. A Literature Review

Gnawali¹

2021

Cureus

View full text Add to dashboard Cite

One of the most devastating public health challenges in the twenty-first century is childhood obesity, and its prevalence is growing at a frightening rate. Premature infants have a greater likelihood of childhood obesity at age six to 16 compared to term infants. This study aims to explore the underlying mechanism of developing childhood obesity in this high-risk group. There are most likely multiple interconnected and supporting mechanisms that put this vulnerable population at risk of childhood obesity. Inflammation is a possible root cause. Prenatal causes included epigenetic changes as well as placental inflammation. Disturbances in hormonal pathways and elevated levels of serum bilirubin are possible explanations. Furthermore, preventable factors in the postnatal period were identified, such as weight gain and exclusive breastfeeding.The prevalence of childhood obesity in preterm infants is high; thus, it is essential to understand the pathophysiology and address any preventable factors to decrease this disease burden.

show abstract

Association of urinary bisphenols with oxidative stress and inflammatory markers and their role in obesity

Zhou,

Zhang,

Sun

et al. 2023

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

Association between neonatal serum bilirubin and childhood obesity in preterm infants

Cited by 5 publications

References 25 publications

Associations between Neonatal Serum Bilirubin and Childhood Obesity in Term Infants

Associations between Neonatal Serum Bilirubin and Childhood Obesity in Term Infants

Prematurity and the Risk of Development of Childhood Obesity: Piecing Together the Pathophysiological Puzzle. A Literature Review

Association of urinary bisphenols with oxidative stress and inflammatory markers and their role in obesity

Contact Info

Product

Resources

About