“…As recommended by Kover and colleagues [ 99 ], the impact of broader economic stability on IQ requires adopting a comprehensive, standardized measure of economic opportunity, such as the International Socio-Economic Index [ 103 ], Child Opportunity Index [ 145 ], or the Area Deprivation Index [ 146 ], the latter two of which incorporate multiple measures of economic disadvantage (e.g., employment opportunities, housing quality, and income). The association between greater neighborhood-level deprivation and lower IQ is strong in the general population [ 147 ], but its relation with IQ has not yet been studied in individuals with syndromic IDDs. The Child Opportunity Index and Area Deprivation Index are worth incorporating in future studies of syndromic IDDs, especially given the low administrative and participant burden for their measurement (i.e., home address).…”