Association between natural killer cells and regression in melanocytic lesions

McKay, Kristopher; Moore, Page C.; Smoller, Bruce R.; Hiatt, Kim M.

doi:10.1016/j.humpath.2011.02.019

Cited by 43 publications

(42 citation statements)

References 22 publications

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“…They in turn may stimulate a subtype of T-helper cells which may then account for the recruitment of cytotoxic T-lymphocytes. 10 The same mechanisms may have occurred in our patient.…”

Section: Commentsupporting

confidence: 70%

Spontaneous Regression of a Conjunctival Malignant Melanoma

Miller

Cook

Jayaramachandran

et al. 2013

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“…They in turn may stimulate a subtype of T-helper cells which may then account for the recruitment of cytotoxic T-lymphocytes. 10 The same mechanisms may have occurred in our patient.…”

Section: Commentsupporting

confidence: 70%

Spontaneous Regression of a Conjunctival Malignant Melanoma

Miller

Cook

Jayaramachandran

et al. 2013

Orbit

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“…A possible mechanism that has been proposed to explain the findings that IL-10 has anti-tumor activity under certain conditions is IL-10-mediated stimulation of NK cells [67,78,82,[84][85][86][87][88]. As well as direct NK stimulation [40,41], IL-10 might indirectly stimulate NK activity in vivo.…”

Section: The Potential Role Of Il-10 In Tumor Inhibitionmentioning

confidence: 99%

The paradoxical role of IL-10 in immunity and cancer

et al. 2015

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“…NK cells infiltrate various tumors including melanoma [8] and their frequencies have been related to favorable clinical outcome [9]. A positive association has been reported between numbers of NK-TILs (anti-CD56 staining) and regression of melanocytic lesions [10].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Functional Characteristics of Blood Natural Killer Cells from Melanoma Patients at Different Clinical Stages

et al. 2013

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Melanomas are aggressive skin tumors characterized by high metastatic potential. Immunotherapy is a valuable alternative for metastatic melanoma patients resistant to chemotherapy. Natural Killer (NK) cells are efficient anti-tumor cytotoxic effectors. We previously showed that blood NK cells from stage IV metastatic melanoma patients display decreased NK receptors and that chemotherapy modifies the functional status of blood NK cells. To investigate the role of NK cells along melanoma progression, we have here studied NK cells from patients at different stages of the disease. First, we showed that ex vivo NK cells from certain stage III–IV patients displayed low degranulation potential. Using a dynamic label-free assay, we found that immunoselected IL-2 activated blood NK cells from patients efficiently lysed melanoma cells through NKp46 and NKG2D receptors, independently to the clinical stage. Moreover, the ex vivo phenotype of circulating NK cells from 33 patients (stage I to IV) was extensively analyzed. NK cells from patients displayed higher variability in the percentages of Natural Cytotoxicity Receptors (NCR) and Natural Killer Group 2D (NKG2D) receptor expression compared to donor NK cells. The main defect was the decreased expression of NCR1 (NKp46) by NK cells from metastatic patients. Interestingly, we found a positive correlation between the NK cell percentages of NKp46 and the duration of stage IV in melanoma patients. Finally, we showed that NK cells infiltrated primary melanomas and displayed a predominant peritumoral distribution. These results are new arguments for the development of NK-based therapies in melanoma patients.

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Association between natural killer cells and regression in melanocytic lesions

Cited by 43 publications

References 22 publications

Spontaneous Regression of a Conjunctival Malignant Melanoma

Spontaneous Regression of a Conjunctival Malignant Melanoma

The paradoxical role of IL-10 in immunity and cancer

Phenotypic and Functional Characteristics of Blood Natural Killer Cells from Melanoma Patients at Different Clinical Stages

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