Objectives:
FOXP3 is a gene related to regulatory T cells existing on chromosome X. This meta-analysis on genetic association studies is conducted to investigate association of FOXP3 polymorphisms with susceptibility to multiple sclerosis (MS).
Methods:
All genetic association studies covering both FOXP3 and multiple sclerosis terms were searched in PubMed, Web of Science and Google Scholar. The information of genotype frequencies were summarized and synthesis of the results was through odds ratio (OR). Heterogeneity and publication bias were investigated using I2 scale and Begg's funnel plot respectively.
Results:
For rs3761546 -3279 C/A polymorphism, AA/AY genotypes was a risk factor in comparison to CC/CY genotypes (P =0.022; OR =1.752; 95% confidence interval [CI] =1.084-2.830; random). AC genotype was a risk factor in comparison to CC/CY genotypes (P =0.004; OR =1.537; 95% CI =1.145-2.062; random) and in comparison to homozygote genotypes (P =0.016; OR =1.216; 95% CI =1.038-1.426; fixed). For rs2232365 -924 G/A polymorphism, 2 significant associations were found according to fixed effect model; of course they were not remained significant in random effect model.
Conclusion:
According to the collected populations, susceptibility to and protection from MS is associated with rs3761546 -3279 C/A upstream polymorphism. However it should be regarded that this association is ethnicity dependent.