Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies

Wu, Yun; Ding, Xiuxiu; Sun, Yehuan; Yang, Haojie; Chen, Jian; Zhao, Xue; Jiang, Yuhong; Lv, Xiaoling; Wu, Zhenqiang

doi:10.1016/j.pnpbp.2013.06.015

Cited by 59 publications

(53 citation statements)

References 34 publications

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“…Meta-analyses of biological candidate gene studies have provided some support for association between MDD and specific variants (Gatt et al, 2015). In particular, nominal associations have been reported in meta-analyses for variants in several serotonergic genes (HTR2A, SLC6A4 HTR1A, TPH2) (Gao et al, 2012;Kishi et al, 2013;Lopez-Leon et al, 2007;Zhao et al, 2014), as well as APOE, DRD4, GNB3, SLC6A3, and MTHFR (Clarke et al, 2010;Lopez-Leon et al, 2007;Wu et al, 2013). Of note, however, none of these genes has been implicated in large GWAS (Wray et al, 2012).…”

Section: Common Genetic Variationmentioning

confidence: 99%

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

Smoller

2015

Neuropsychopharmacol

361

243

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Research into the causes of psychopathology has largely focused on two broad etiologic factors: genetic vulnerability and environmental stressors. An important role for familial/heritable factors in the etiology of a broad range of psychiatric disorders was established well before the modern era of genomic research. This review focuses on the genetic basis of three disorder categories-posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and the anxiety disorders-for which environmental stressors and stress responses are understood to be central to pathogenesis. Each of these disorders aggregates in families and is moderately heritable. More recently, molecular genetic approaches, including genome-wide studies of genetic variation, have been applied to identify specific risk variants. In this review, I summarize evidence for genetic contributions to PTSD, MDD, and the anxiety disorders including genetic epidemiology, the role of common genetic variation, the role of rare and structural variation, and the role of gene-environment interaction. Available data suggest that stress-related disorders are highly complex and polygenic and, despite substantial progress in other areas of psychiatric genetics, few risk loci have been identified for these disorders. Progress in this area will likely require analysis of much larger sample sizes than have been reported to date. The phenotypic complexity and genetic overlap among these disorders present further challenges. The review concludes with a discussion of prospects for clinical translation of genetic findings and future directions for research.

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Section: Common Genetic Variationmentioning

confidence: 99%

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

Smoller

2015

Neuropsychopharmacol

361

243

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“…Homozygous variant of C677T MTHFR gene polymorphism only have 30% of enzyme activity while the heterozygous variant maintain its activity at 65% as compared to wild-type (Rozen, 1996). Disruption of enzyme function due to MTHFR gene polymorphism will increase homocysteine level (Wu et al, 2013). Homocysteine and its metabolite might have a direct excitotoxic effect on N-methyl-D-aspartate glutamate (NMDA) receptor and blocks methylation process of biogenic amines such as neurotransmitter and phospholipid in the central nervous system (Bjelland, Ueland, and Vollset, 2003).…”

Section: Resultsmentioning

confidence: 99%

C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Treatment Response in Schizophrenia Patients

Muthmainah¹,

Kurniasari²,

Fanani³

et al. 2017

Proceedings of the Health Science International Conference (HSIC 2017)

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“…34 Several meta-analysis studies illustrate the utility of the technique in identifying genes of small effects like MTHFR with phenotypes like -NTD, 35 Down syndrome, 36 Cardiovascular disease, 37 Migraine, 38 Schizophrenia, 39 bipolar disorder, 40 and depression. 41 The present meta-analysis (including 1019 case mothers and 16494 controls) was performed to assess the relationship between MTHFR A1298C polymorphism and NSCL/P with ten published case control studies, but no significant association was found in the total population. The main strength of the present study was that heterogeneity and publication bias were not observed.…”

Section: Discussionmentioning

confidence: 98%

Maternal methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism and risk of nonsyndromic Cleft lip and/or Palate (NSCL/P) in offspring: A meta-analysis

Rai

2014

Asian J Med Sci

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Objective: Methyleneterahydrofolate reductase (MTHFR) A1298C polymorphism has been reported a risk factor for nonsyndromic cleft/palate (NSCL/P) in several published articles but results were inconclusive. To confirm the association between maternal MTHFR A1298C polymorphism and NSCL/P risk, a meta-analysis was conducted. Method: Case control articles for maternal MTHFR A1298C polymorphism and NSCL/P risk were identified by search of databases including PubMed, Google Scholar, Elsevier and Springer Link for the period up to December, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Results: Meta-analysis of ten included studies showed that there was no significant association between maternal MTHFR A1298C polymorphism and risk of NSCL/P under five genetic models (for C versus A, OR= 1.007, 95 % CI= 0.89-1.13, P=0.90; for CC versus AA, OR=0.851, 95 % CI = 0.63-1.15, P=0.30.; for AC versus AA, OR= 1.033, 95 % CI= 0.88-1.21, P= 0.69; for CC+AC versus AA, OR= 1.005, 95 % CI= 0.86-1.17, P=0.94; for CC versus AC+AA, OR= 0.86, 95 % CI= 0.64-1.15, P= 0.32). Conclusion: In conclusion, results of present meta-analysis demonstrate that maternal MTHFR A1298C polymorphism may not be a risk factor for developing NSCL/P in offspring. Further studies with large sample sizes are needed to evaluate the association of maternal MTHFR A1298C polymorphism with NSCL/P in more detail.

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Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies

Cited by 59 publications

References 34 publications

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Treatment Response in Schizophrenia Patients

Maternal methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism and risk of nonsyndromic Cleft lip and/or Palate (NSCL/P) in offspring: A meta-analysis

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