Association between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls

Abedinzadeh, Mehdi; Zare-Shehneh, Masoud; Neámatzadeh, Hossein; Abedinzadeh, Maryam; Karami, Hormoz

doi:10.7314/apjcp.2015.16.11.4525

Cited by 28 publications

(26 citation statements)

References 31 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This C677T polymorphism in exon 4 of MTHFR gene is responsible for the amino acid replacement of alanine by valine toward codon 222 (A222V) (Abedinzadeh, Zare‐Shehneh, Neamatzadeh, Abedinzadeh, & Karami, ).…”

Section: Introductionmentioning

confidence: 99%

Study of C677T variant of methylene tetrahydrofolate reductase gene in autistic spectrum disorder Egyptian children

Ismail

Senna

Behiry

et al. 2019

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Background: Autism spectrum disorders (ASD) is a heterogeneous neurodevelopmental disease, various articles reported that dysfunctional folate-methionine pathway enzymes might assume a paramount part in the pathophysiology of autism. Methylene tetrahydrofolate reductase (MTHFR) is a basic catalyst for this pathway, also MTHFR gene C677T variant accounted as a risk factor of autism.Objective: The present study aimed to investigate the association of MTHFR gene rs1801133(C677T) variant among Egyptian autistic children. Methods: The study included 78 autistic children, and 80 matched healthy control children. Full clinical and radiological examinations were conducted. MTHFR genetic variant, rs1801133(C677T) was studied by using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) methods followed by direct sequencing technique. Results: MTHFR (C677T) allele frequency was found to be higher significantly in ASD cases compared with nonautistic children. Also, we had a higher distribution of combined CT + TT genotypes among autistic patients with consanguinity and family history of psychological disease. In Gastrointestinal tract (GIT) and sleep disorders showed a higher distribution of hetero CT genotype as well as combined CT + TT genotypes. Conclusion: This study demonstrated a role of MTHFR gene (C667T) variant with the increased risk for ASD. K E Y W O R D S autism, MTHFR, variant, C667T

show abstract

Section: Introductionmentioning

confidence: 99%

Study of C677T variant of methylene tetrahydrofolate reductase gene in autistic spectrum disorder Egyptian children

Ismail

Senna

Behiry

et al. 2019

American J of Med Genetics Pt B

View full text Add to dashboard Cite

show abstract

“…Most of the studies focusing on the relationship between PCa and SNPs of MTHFR paid close attention to MTHFR polymorphism and PCa risk and have conflicting results. A recent meta-analysis which enrolled 22 studies revealed that the MTHFR C677T polymorphism did not contribute to the risk of PCa in the overall population of Caucasians, but indicated that it may play a role in PCa development in Asian males23. Another recently published meta-analysis which included over 20,000 participants declared that the C677T CT polymorphism of MTHFR may be a risk factor of PCa in East Asians, and the association between A1298C variant and PCa risk may vary in different ethnic populations21.…”

Section: Discussionmentioning

confidence: 99%

“…Among these variants, rs1801133 (c. 677C>T) and rs1801131 (c.1298A>C) are two most extensively reported polymorphisms with a global minor allele frequency (GMAP) 0.245 and 0.249, respectively1920. These two variants have shown to be associated with the risk of PCa, although somewhat conflicting results have been reported21222324.…”

mentioning

confidence: 99%

MTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai

Zhou

Zhao

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Methylenetetrahydrofolate reductase (MTHFR) c.677C>T and c.1298A>C variants were known to be associated with prostate cancer (PCa) risk with conflicting results, because of MTHFR and nutrient status interaction in the prostate development. In this large-scale, hospital-based, case-control study of 1817 PCa cases and 2026 cancer-free controls, we aimed to clarify the association between these two MTHFR variants and PCa risk in Shanghai and to explore the underlying molecular mechanisms. We found that both the heterozygous CT (adjusted OR = 0.78, 95% CI: 0.67–0.92) and the homozygous TT genotypes (adjusted OR = 0.68, 95% CI: 0.55–0.83) of c.677C>T were associated with a significantly decreased risk of PCa compared with homozygous wild-type CC genotype, respectively, using multivariate logistic regression. Furthermore, we confirmed that MTHFR c.677T allele was related to an increased serum homocysteine level in the Han Chinese population in Shanghai. In the cultured PCa cell lines, we observed that MTHFR c.677T could elevate the cellular homocysteine level and cause DNA damage, thus increasing cell apoptosis and finally inhibiting cell proliferation. In conclusion, MTHFR c.677T was a protective factor of PCa risk in ethnic Han Chinese males by inducing DNA damage and cell apoptosis.

show abstract

“…Risk factors for develop ing localized prostate cancer are not well known. However, a family history of prostate cancer and age has long been identified as an important risk for development of the dis ease [5,6]. Although several notable advances in our knowledge about risk factors of bladder and prostate cancers were published in recent years, their exact mechanisms remains poorly understood [7].…”

Section: Introductionmentioning

confidence: 99%

“…Although several notable advances in our knowledge about risk factors of bladder and prostate cancers were published in recent years, their exact mechanisms remains poorly understood [7]. It is suggested that both bladder and prostate cancers are caused by a combination of genetic and environmental risk factors [5].…”

Section: Introductionmentioning

confidence: 99%

Association of NAD(P)H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers – a Systematic Review and Meta-Analysis

Abedinzadeh¹,

Moghimi²,

Dastgheib³

et al. 2020

Klin Onkol

Self Cite

View full text Add to dashboard Cite

Background: Number of studies has been performed to investigate the association of NAD(P)H quinine oxidoreductase 1 (NQO1) rs1800566 polymorphism with risk of bladder and prostate cancers, but presented inconsistent results. Therefore, we performed a meta-analysis to provide a comprehensive data on the association of NQO1 rs1800566 polymorphism with bladder and prostate cancers. Methods: All eligible studies were identified in PubMed, Google Scholar, EMBASE, and China National Knowledge Infrastructure databases before June 01, 2019. Results: A total of 22 case-control studies includ ing 15 studies with 4,413 cases and 4,275 controls on bladder cancer and 7 studies with 762 cases and 1,813 controls on prostate cancer were selected. Over all, pooled data showed that the NQO1 rs1800566 polymorphism was significantly associated with an increased risk of bladder cancer (T vs. C: OR 1.300; 95% CI 1.112-1.518; P = 0.001; TT vs. CC: OR 1.415; 95% CI 1.084-1.847; P = 0.011; TC vs. CC: OR 1.389; 95% CI 1.111-1.738; P = 0.004; TT + TC vs. CC: OR 1.428; 95% CI 1.145-1.782; P = 0.002) and prostate cancer (TC vs. CC: OR 1.276; 95% CI 1.047-1.555; P = 0.016; TT + TC vs. CC: OR 1.268; 95% CI 1.050-1.532; P = 0.014). The stratified analysis by ethnicity revealed an increased risk of bladder cancer among Caucasians and prostate cancer among Asians. Conclusion: This meta-analysis suggested that the NQO1 rs1800566 polymorphism was significantly associated with increased risk of bladder and prostate cancers. Key wordsurinary bladder neoplasms -prostatic neoplasms -NQO1 gene -polymorphismmeta-analysisThe authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.

show abstract

Association between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls

Cited by 28 publications

References 31 publications

Study of C677T variant of methylene tetrahydrofolate reductase gene in autistic spectrum disorder Egyptian children

Study of C677T variant of methylene tetrahydrofolate reductase gene in autistic spectrum disorder Egyptian children

MTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai

Association of NAD(P)H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers – a Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About