Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort

Lajin, Bassam; Sakur, Amir Alhaj; Michati, Roula; Alachkar, Amal

doi:10.1016/j.ajp.2012.03.002

Cited by 35 publications

(21 citation statements)

References 44 publications

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“…Also, this result is partially in accordance with that of Lajin et al [41] who found a statistical significant association for MTHFR 677TT genotype under the recessive model in the male patients subgroup and MTHFR 677CT genotype under the over dominant model in the total patient group [41]. On the other hand, Kim et al [42] found that there was no significant association between MTHFR C677T polymorphism and the risk of schizophrenia, similar to the results obtained by Tan et al [35] and Kim et al [42].…”

Section: Discussionsupporting

confidence: 93%

MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder

El-Hadidy

Abdeen

El-Aziz

et al. 2014

BioMed Research International

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Objective. Several studies with contradictory results from different cultures about association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia and bipolar disorders. Little is known about this association in Arab culture and Egypt. So the present study aimed to assess the association of MTHFR C677T polymorphism in bipolar disorder (BD) and schizophrenia in comparison to control group. The association between MTHFR C677T polymorphism and the age at onset in schizophrenia or BD was also studied. Methods. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to examine the genotype and allele frequencies of MTHFR C677T polymorphism in 149 healthy subjects and 134 bipolar and 103 schizophrenia patients. Results. In BD and schizophrenia, there was a higher prevalence of MTHFR C677T polymorphism than healthy subjects. Earlier age at onset was found in patients with BD, carrying one copy of the T allele or CT genotypes but not in patients with schizophrenia. Conclusion. The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.

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Section: Discussionsupporting

confidence: 93%

MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder

El-Hadidy

Abdeen

El-Aziz

et al. 2014

BioMed Research International

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“…Several epidemiological studies suggested that the MTRR A66G polymorphism was associated with many disorders, including birth defects [15], [18], [59]–[61], cardiovascular diseases [19], [62], [63], and cancers [20]. In addition, it was reported that interaction between the MTRR A66G and MTHFR C677T polymorphisms could increase the risk of neural tube defects [59]–[61] and schizophrenia [2]. The significant gene-gene interactions between the MTHFR C677T, A1298C, and MTRR A66G polymorphisms highlight the importance of multi-locus analyses in the risk prediction of multi-factorial disorders.…”

Section: Discussionmentioning

confidence: 99%

Geographical Distribution of MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in China: Findings from 15357 Adults of Han Nationality

et al. 2013

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BackgroundMethylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms are important genetic determinants for homocysteine (Hcy) levels, and are associated with several disorders. These polymorphisms are heterogeneously distributed worldwide. Our objective was to explore the geographical distributions of these polymorphisms in China.Methodologies15357 healthy adults were recruited from 10 regions. Buccal samples were collected and genomic DNA was isolated. Genotyping was performed using the fluorogenic 5′-nuclease assay.Principal FindingsThe prevalence of the three polymorphisms among different populations from China varied significantly and showed apparent geographical gradients. For MTHFR C677T, the frequencies of the 677T allele and the 677TT genotype were significantly higher among northern populations and ranged from the lowest values (24.0% and 6.4%, respectively) in Hainan (southern) to the highest values (63.1% and 40.8%, respectively) in Shandong (northern). For MTHFR A1298C, the 1298C allele and the 1298CC genotype frequencies were significantly higher among southern populations and increased from low values (13.1% and 1.4%, respectively) in Shandong to high values (25.7% and 6.7%, respectively) in Hainan. For A66G, the 66G allele and the 66GG genotype frequencies increased from lower values (23.7% and 5.4%, respectively) in Shandong to higher values (29.2% and 8.6%, respectively) in Hainan. The overall frequency of the 677T allele, 677TT genotype, 1298C allele, 1298CC genotype, 66G allele and 66GG genotype in the Chinese Han population was 45.2%, 23.2%, 18.6%, 3.9%, 25.7%, and 6.6%, respectively. No gender differences were found in the prevalence of both the MTHFR C677T and MTRR A66G polymorphisms.ConclusionsThis study indicates that there are marked geographical variations in the prevalence of the three polymorphisms among Chinese Han populations. Our baseline data may be useful for future researches in related fields.

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“…MTHFR converts 5,10-methylenetetrahydrofolate, in a reaction catalysed by MTR. MTRR is a coenzyme that catalyses the remethylation of homocysteine (Hcy) to methionine via a cobalamin and folate-dependent reaction [6][7][8]10,18].…”

Section: Introductionmentioning

confidence: 99%

“…In the MTHFR gene, C[677]T (rs1801133) and A[1298]C (rs1801131) polymorphisms affecting the activity of the methionine synthase reductase have been identified. They have been associated with decreased enzyme activity and increased levels of plasma homocysteine [3,4,[8][9][10]. The MTRR A[66]G (rs1801394) polymorphism alters isoleucine into a methionine residue in the protein chain.…”

Section: Introductionmentioning

confidence: 99%