Association Between Motor and Cognitive Performances in Elderly With Atrial Fibrillation: Strat-AF Study

Salvadori, Emilia; Galmozzi, Francesco; Uda, Francesca; Barbato, Carmen; Camilleri, Eleonora; Cesari, Francesca; Chiti, Stefano; Diciotti, Stefano; Donnini, Samira; Formelli, Benedetta; Galora, Silvia; Giusti, Betti; Gori, Anna Maria; Marzi, Chiara; Melone, Anna; Mistri, Damiano; Pescini, Francesca; Pracucci, Giovanni; Rinnoci, Valentina; Sarti, Cristina; Fainardi, Enrico; Marcucci, Rossella; Poggesi, Anna

doi:10.3389/fneur.2020.571978

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…Very few studies have focused on the interrelations of cognition and mobility in patients with cerebrovascular disease. Recently, associations between measures of motor and cognitive abilities have been reported in older individuals with atrial fibrillation, although these relationships were not related to cerebral lesion burden [42]. In chronic cerebrovascular disease, executive functions, but not global cognition, has been associated with risk of falls, while balance had no correlations with neuropsychological measures [43].…”

Section: Discussionmentioning

confidence: 99%

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Jokinen

Laakso

Ahlström

et al. 2021

Euro J of Neurology

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Section: Discussionmentioning

confidence: 99%

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Jokinen

Laakso

Ahlström

et al. 2021

Euro J of Neurology

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“…Recently, associations between measures of motor and cognitive abilities have been reported in older individuals with atrial fibrillation, although these relationships were not related to cerebral lesion burden. 17 In chronic cerebrovascular disease, executive functions, but not global cognition, has been associated with risk of falls, while balance had no correlations with neuropsychological measures. 16 The role of WMH in old-age disability in terms of impaired IADL has been well documented.…”

Section: Discussionmentioning

confidence: 96%

“…16 Another study has found an association between mobility and cognitive performance independently of cerebral lesion burden among older patients with atrial fibrillation. 17 This study investigated the relationships and functional significance of cognitive and motor abilities in older individuals with different degrees of WMH by using standard physical and neuropsychological assessments and quantitative evaluation of brain changes on structural MRI. Specifically, our objectives were to a) confirm the associations of domain-specific cognitive functions (global cognition, executive functions, processing speed and memory) and motor performances (gait speed, balance and functional mobility) with WMH and GM volumes b) investigate the reciprocal relationships between different motor and cognitive functions c) show the associations and interactions of cognitive and motor functions on instrumental activities in daily living (IADL) and quality of life d) explore the extent to which cognitive and motor functions mediate the effect of WMH and GM volumes on functional outcome.…”

Section: Introductionmentioning

confidence: 99%

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Jokinen

Laakso

Ahlström

et al. 2021

Preprint

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Objective: Cognitive and motor impairments are the key clinical manifestations of cerebral small vessel disease (SVD), but their interrelations and combined effects on functional outcome have not been elucidated. We investigated the associations between cognitive and motor functions and their interactions and mediating effects on instrumental activities of daily living (IADL) and quality of life in older individuals with various degrees of white matter hyperintensities (WMH). Methods: Participants of the Helsinki Small Vessel Disease Study (n=152) were assessed according to an extensive clinical, neuropsychological and MRI protocol. Cognitive composite scores for global cognition, processing speed, executive functions and memory were constructed from multiple tests within each domain. Physical examination included measures of gait speed, balance (single-leg-stance) and functional mobility (timed-up-and-go test). IADL was evaluated with a proxy-based Amsterdam IADL questionnaire and quality of life with a self-report EUROHIS-Qol index. Volumes of WMH and gray matter (GM) were obtained with automated segmentation. Sets of linear regression analyses were used to model the associations between motor and cognitive performances, WMH and GM volumes, and IADL and quality of life. Results: Domain-specific cognitive and motor functions had strong interrelations with each other, and they were significantly associated with IADL, quality of life as well as WMH and GM volumes. A consistent pattern on significant interactions between cognitive and motor functions was found on IADL, but not on quality of life. In particular, low cognitive scores together with decline in the timed-up-and-go test and gait speed were strongly related to impaired IADL. The association of WMH volume with IADL was mediated by global cognition, whereas the association of GM volume with IADL was mediated by global cognition and timed up-and-go performance. Conclusion: The results highlight the complex interplay and synergism between motor and cognitive abilities on functional outcome in SVD. The combined effect of motor and cognitive disturbances on IADL is likely to be greater than the individual effects of each of the two impairments. WMH and brain atrophy contribute to disability through cognitive and motor impairment.

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“…21 An increasing amount of evidence points to a close connection between motor and cognitive skills, while the fundamental mechanisms that might underlie these associations are not fully understood. 23,24 Using and manipulating dget spinners, a complex motor activity requiring hand-eye coordination, is dependent on a very specialised area of the precentral gyrus known as the "hand-knob" sector, which controls the ne control of hand muscles and the frontal eye elds. This hand-knob area has variable functional and anatomical connections to the parietofrontal areas 25 and thus it is plausible that repeated manipulation of dget spinners may reinforce these functional connections with the prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Effect of fidget spinners in enhancement of cognitive skills in healthy individuals: An interventional study

Biswas,

Kumar,

Rani

2023

Journal of the Neurological Sciences

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Association Between Motor and Cognitive Performances in Elderly With Atrial Fibrillation: Strat-AF Study

Cited by 8 publications

References 36 publications

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

Effect of fidget spinners in enhancement of cognitive skills in healthy individuals: An interventional study

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