Association Between Mood Disorders and Risk of COVID-19 Infection, Hospitalization, and Death

Ceban, Felicia; Nogo, Danica; Carvalho, Isabelle P.; Lee, Yena; Nasri, Flora; Xiong, Jiaqi; Lui, Leanna M.W.; Subramaniapillai, Mehala; Gill, Hartej; Liu, Rene N.; Joseph, Prianca; Teopiz, Kayla M.; Cao, Bing; Mansur, Rodrigo B.; Lin, Kangguang; Rosenblat, Joshua D.; Ho, Roger; McIntyre, Roger S.

doi:10.1001/jamapsychiatry.2021.1818

Cited by 180 publications

(194 citation statements)

References 87 publications

Supporting

Mentioning

162

Contrasting

Order By: Relevance

“…Previous systematic reviews and meta-analyses have shown an elevated risk for COVID-19-related morbidity and mortality in people with mental disorders ( 8 – 10 , 29 ). This is added on top of an already decreased life span of about 20 years for people suffering from severe mental illness ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination Rates in a Cohort Study of Patients With Mental Illness in Residential and Community Care

et al. 2021

View full text Add to dashboard Cite

Background: Patients with mental illness are at increased risk for COVID-19-related morbidity and mortality. Vaccination against COVID-19 is important to prevent or mitigate these negative consequences. However, concerns have been raised over vaccination rates in these patients.Methods: We retrospectively examined vaccine uptake in a large sample of Belgian patients admitted to or residing in a university psychiatric hospital or community mental health care setting between 29th of March 2021 and 30th of September 2021 in the Flanders Region. All patients were offered vaccination. Descriptive statistics were used to analyse the data. Logistic regression was used to examine factors associated with vaccine uptake.Results: 2,105 patients were included in the sample, of which 1,931 agreed to be vaccinated, corresponding with a total vaccination rate of 91.7%. Logistic regression showed an effect of the diagnosis “other disorders” (OR = 0.08, CI = 0.005–0.45), age (OR = 1.03, CI = 1.02–1.04) and residing in the psychosocial care center (OR = 0.50, CI = 0.32–0.80) on vaccination status.Conclusion: Vaccine uptake among people with mental illness is high and comparable to the general population, when implementing a targeted vaccination program.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination Rates in a Cohort Study of Patients With Mental Illness in Residential and Community Care

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Among mental health disorders evaluated in one study, schizophrenia spectrum disorder was shown to be related to mortality among patients with COVID-19 though an association was not seen among patients with mood or anxiety disorders ( 27 ). Additionally, a large-scale meta-analysis did not find a relationship between preexisting mood disorders and risk for infection, hospitalization and death ( 28 ). In contrast, a recent analysis of COVID-19 infection and mortality found the odds of mortality was 2.78 times greater among patients testing positive who had a history of mood disorders ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing COVID-19 Infection in older individuals: History of Alcohol Use Disorder, Major Depressive illness, genetic variation and current use of alcohol

Hill

Holmes

Wellman

2021

Preprint

View full text Add to dashboard Cite

Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic continues to be a major public health problem. Vulnerable populations include older individuals with presumed weakening of the immune response. Identification of factors influencing COVID-19 infection could provide an additional means for protecting such individuals. Methods: Members of a family study previously interviewed as middle aged individuals were re-contacted and asked to participate in extended phone interview (2-3 hours) covering past and current mental health issues, physical health diagnoses, use of alcohol and drugs, and exposure to anyone with COVID-19. The average follow-up period was 32 years. Detailed medication use was collected to confirm medical diagnoses and to reveal possible protective effects of particular drug classes currently prescribed for the participant by their physician. Serology was available for red cell antigens (ABO, Kell, Duffy, Kidd, Rhesus) and HLA subtypes. Analyses were conducted to contrast COVID-19 + and COVID-19 - individuals for physical and mental health diagnoses, use of alcohol and drugs, and red cell and HLA serology. Additionally, analyses were conducted to contrast these groups with a group reporting known exposure but absence of COVID-19 symptoms or diagnosis by a health professional. Results: Interviews were completed between September 2020 and November 2021. A total of 42 of the 90 individuals interviewed had been vaccinated at the time of interview. At the time of interview, 11.1% reported having developed COVID-19. Using quantity per occasion (QPO) and quantity by frequency (QXF) totals in the past month by type of alcohol consumed, we found a significant association between QPO for liquor (p=0.017) and marginal effects for QXF for liquor consumption (p=0.06). Exposed individuals who were COVID-19 negative tended to drink more liquor than those who were positive, an average of about one drink per day. Beer and wine consumption were not statistically significant. A diagnosis of alcohol use disorder at baseline evaluation was not a significant predictor of being COVID positive or negative. Self-reported current depression or depression in the past only was not a predictor of COVID-19 status based on a single question "Are you depressed currently or only in the past?". In contrast, completion of a clinical interview designed to elicit depressed mood and concurrent symptoms for determination of the lifetime presence or absence of a depressive episode did reveal a significant effect. Comparison of responses at baseline to follow-up showed those most resilient to developing COVID-19 were those without evidence of a depressive episode by lifetime history at both points in time. Physical health issues were analyzed for those that were frequently occurring in our sample such as hypertension but not found to be significant. BMI was analyzed and found to be statistically non-significant. Analysis of HLA variation across the whole sample did not reveal a significant association but among males two variants, A1 and B8, did show significant variation associated with COVID-19+ and COVID-19- status. Analyses of the red cell antigens revealed one significant red cell effect; Kidd genotypic variation was associated with COVID-19 status. Interpretation: We tentatively conclude that use of specific types of alcohol, namely liquor, is associated with reduced frequency of COVID-19. However, the amount is low, averaging about 1 drink per day. Enlarged samples are needed to confirm these results. The finding that past history of alcohol use disorder does not increase likelihood of developing COVID-19 is important. It should be noted that the 34 individuals diagnosed with AUD at baseline had survived an average of 32 years in order to participate in the current interview suggesting they may be especially resilient to adverse health conditions. The finding that a single question designed to elicit the presence or absence of depressed mood either currently or in the past was not a risk factor for COVID-19 in contrast to report of a clinically significant past history of a depressive episode based on more extensive examination using DSM criteria is important. Results for the KIDD blood group are novel and warrant further investigation.

show abstract

“…A number of authors have noted the bidirectional link between COVID-19 and mental illness; COVID-19 elevates risk of mental illness and mental illness elevates the risks of COVID-19 (Taquet et al 2021;Wang et al 2021). A recent meta-analysis has robustly demonstrated that pre-existing mood disorders are associated with higher rates of hospitalisation and death from COVID-19 infection (Ceban et al 2021). Additionally, individuals with mental illness requiring inpatient or residential care, by virtue of congregated living and difficulty in adherence to risk mitigation strategies can be at increased risk of exposure and transmission of COVID-19 (Kozloff et al 2020).…”

Section: Mental Health and Societal Impacts Of Covid-19mentioning

confidence: 99%

The global impact on mental health almost 2 years into the COVID-19 pandemic

Gavin

Lyne

McNicholas

2021

Ir. j. psychol. Med.

View full text Add to dashboard Cite

Approaching 2 years into a global pandemic, it is timely to reflect on how COVID-19 has impacted the mental health of the global population. With research continuing apace, a clearer picture should crystallise in time. COVID-19 has undoubtedly had some impact on population mental health, although the severity and duration of this impact remain less clear. The exceptional period of COVID-19 has provided a unique prism through which we can observe and consider societal mental health. This is a momentous time to be involved in mental health research as we strive to understand the mental health needs of the population and advocate for adequate resourcing to deliver quality mental healthcare in the post-pandemic period.

show abstract

Association Between Mood Disorders and Risk of COVID-19 Infection, Hospitalization, and Death

Cited by 180 publications

References 87 publications

COVID-19 Vaccination Rates in a Cohort Study of Patients With Mental Illness in Residential and Community Care

COVID-19 Vaccination Rates in a Cohort Study of Patients With Mental Illness in Residential and Community Care

Factors influencing COVID-19 Infection in older individuals: History of Alcohol Use Disorder, Major Depressive illness, genetic variation and current use of alcohol

The global impact on mental health almost 2 years into the COVID-19 pandemic

Contact Info

Product

Resources

About