Association Between Monocyte-to-Lymphocyte Ratio and Hematoma Progression After Cerebral Contusion

Abstract

Background The objective of this research was to examine the impact of the monocyte-to-lymphocyte ratio (MLR) on the advancement of hematoma after cerebral contusion. Methods The clinical information and laboratory test findings of people with cerebral contusion were retrospectively analyzed. Using the tertiles of MLR, the study participants were categorized into three groups, enabling the evaluation of the correlation between MLR and the advancement of hematoma after cerebral contusion. Results Among the cohort of patients showing progression, MLR levels were significantly higher compared with the nonprogress group (P < 0.001). The high MLR group had a significantly higher proportion of patients with hematoma progression compared with the medium and low MLR groups. However, the medium MLR group had a lower proportion of patients with hematoma progression compared with the low MLR group. High MLR levels were independently linked to a higher risk of hematoma progression (Odds Ratio 3.546, 95% Confidence Interval 1.187–10.597, P = 0.024). By incorporating factors such as Glasgow Coma Scale score on admission, anticoagulant/antiplatelet therapy, white blood cell count, and MLR into the model, the predictive performance of the model significantly improved (area under the curve 0.754). Conclusions Our study suggests that MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion. Further research is necessary to investigate the underlying pathological and physiological mechanisms that contribute to the association between MLR and the progression of hematoma after cerebral contusion and to explore its clinical implications.

Inflammation Indexes PLR, SII, AISI, MLR, NLPR and MCVL in Peripartum Treated Thrombophilia Patients Undergoing Cesarean Section at Term-STROBE Compliant

“…There was no correlation between inflammation indexes and the Rh blood factor before or after birth in non-thrombophilia patients. MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion [59]. The MLR was significantly higher in the HELLP group than in the normal pregnant patient control group at the delivery time 12 [60].…”

Inflammation Indexes PLR, SII, AISI, MLR, and MCVL in Peripartum Treated Thrombophilia Peripartum Patients Undergoing Cesarean Section at Term

“…There was no correlation between inflammation indexes and the Rh blood factor before or after birth in non-thrombophilia patients. MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion [43]. The MLR was significantly higher in the HELLP group than in the normal pregnant patient control group at the delivery time [44].…”

Association between monocyte to lymphocyte ratio and diabetic foot ulcer in the population of the US with diabetes based on the 1999-2004 National Health and Nutrition Examination Survey data: a retrospective cross-sectional study

“…The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and MLR are indicators of these immune cells. Numerous studies have demonstrated that these markers can predict the presence of systemic inflammation and may be helpful in the diagnosis of various disorders ( 8 , 20 , 21 , 31 ). Recently, some studies have shown that the high MLR is associated with the occurrence and progression of diabetes complications, including diabetic nephropathy, DR, and PAD ( 7 , 22 – 24 , 32 ).…”

“…It has been widely studied in various inflammation-related disorders, such as cancer, tuberculosis and cardiovascular diseases, and has proven to be a reliable biomarker of systemic inflammation ( 17 – 19 ). Elevated MLR has been associated with poor prognosis and accelerated disease progression in several disorders, including acute kidney injury and hematoma after cerebral contusion ( 20 , 21 ). Recently, some studies have shown that the MLR is associated with the occurrence and progression of diabetes complications, including diabetic nephropathy, diabetic retinopathy (DR), and PAD ( 7 , 22 – 24 ).It is reasonable to assume that MLR may play a significant role in the onset and progression of DFU, given the mounting body of research emphasizing its importance in diabetes complications ( 7 , 22 – 24 ).…”