Association Between Monocyte Count and Preoperative Deep Venous Thrombosis in Older Patients with hip Fracture: A Retrospective Study

Wang, Zhicong; Zhou, Qing; Liu, Hailong; Zhang, Jianjun; Zhu, Zhonglun; Wu, Jianhui; Chen, Xue; Liu, Yuehong

doi:10.1177/10760296221100806

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…In a recent retrospective study of 674 older patients with hip fracture Wang et al found that a monocyte count above 0.6 × 10E9/L in a multivariate analysis was independently associated with a preoperative risk of DVT (OR 1.705 × 95%CI 1.12–2.59), but not for PE [ 22 ]. A register study with Mendelian Randomization on a genome-wide association study He et al found that a genetically predicted monocyte count was negatively correlated with VTE, but does not discriminate between DVT and PE, and has no information about time of VTE examination blood sample drawn [ 23 ], and level of monocyte count.…”

Section: Discussionmentioning

confidence: 99%

Monocyte recruitment in venous pulmonary embolism at time of cancer diagnosis in upper gastrointestinal cancer patients

Jakobsen,

Frøkjaer,

Fisker

et al. 2023

J Thromb Thrombolysis

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Upper gastrointestinal cancer is frequently complicated by venous thromboembolisms (VTE), especially pulmonary embolisms (PE) increase the mortality rate. Monocytes are a part of the innate immune system and up-regulation may indicate an ongoing inflammatory response or infectious disease and has lately been associated with a moderate risk of suffering from VTE. This prospectively study aims to compare the incidence of pulmonary embolism with markers of coagulation and compare it to the absolute monocyte count. A consecutive cohort of 250 patients with biopsy proven upper gastrointestinal cancer (i.e. pancreas, biliary tract, esophagus and gastric cancer) where included at the time of cancer diagnosis and before treatment. All patients underwent bilateral compression ultrasonography for detection of deep vein thrombosis (DVT). Of these 143 had an additionally pulmonary angiografi (CTPA) with the staging computer tomography. 13 of 250 patients (5.2%) had a DVT and 11 of 143 (7.7%) had CTPA proven PE. PE was significantly more common among patients with elevated D-dimer (OR 11.62, 95%CI: 1.13–119, P = 0.039) and elevated absolute monocyte count (OR 7.59, 95%CI: 1.37–41.98, P = 0.020). Only patients with pancreatic cancer had a significantly higher risk of DVT (OR 11.03, 95%CI: 1.25–97.43, P = 0.031). The sensitivity of absolute monocyte count was 63.6 (95%CI: 30.8–89.1) and specificity 80.3 (95%CI: 72.5–86.7), with a negative predictive value of 96.4 (95%CI: 91–99) in PE. An increased absolute monocyte count was detected in patients suffering from PE but not DVT, suggesting a possible interaction with the innate immune system.

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Section: Discussionmentioning

confidence: 99%

Monocyte recruitment in venous pulmonary embolism at time of cancer diagnosis in upper gastrointestinal cancer patients

Jakobsen,

Frøkjaer,

Fisker

et al. 2023

J Thromb Thrombolysis

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“…As described above, these blood indicators were significant predictors of death after hip fracture ( 10 , 13 – 15 ). Furthermore, we also found that high monocyte level was associated with an increased risk of deep venous thrombosis (DVT) in older patients with hip fracture, thereby leading to a 3.21-fold increase in the 30-day mortality ( 29 , 30 ). From these findings, we hypothesized that high SIRI level would be an independent predictor of subsequent death following hip fracture.…”

Section: Introductionmentioning

confidence: 85%

Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study

Fang,

Gao,

Wang

et al. 2024

Front. Med.

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ObjectiveWith a rapidly aging global population, the assessment of mortality risk following hip fracture in older adults has received increasing attention. Recently, the system inflammation response index (SIRI) has been identified as a novel prognostic marker to reflect both systemic inflammation and immune status. However, it is not yet known whether SIRI is a potential predictor of subsequent death in hip fracture patients. Therefore, this study aimed to investigate the association between SIRI and mortality in older patients with hip fracture.MethodsA total of 1,206 older hip fracture patients undergoing surgery between January 2013 and December 2022 were consecutively derived from our longitudinal database. Patients were divided into three groups according to SIRI tertiles, calculated as neutrophil × monocyte / lymphocyte. Survival status was obtained from medical records or telephone interviews, and the study outcome was all-cause mortality after hip fracture at the longest follow-up. Multivariate Cox proportional hazard model and restricted cubic spline (RCS) regression model were used to evaluate the association between SIRI and mortality. Moreover, a series of sensitivity analyses were conducted to further validate the robustness of the association.ResultsDuring a median follow-up of 43.85 months, 337 patients (27.94%) died. After full adjustment, each unit increase in SIRI was significantly associated with a 2.2% increase in overall mortality (95% confidence interval [CI]: 1.001–1.042, p = 0.029). Similarly, compared with the first tertile of SIRI, the second and third tertile showed a 1.335-fold (95% CI: 1.011–1.762, p = 0.042) and 1.447-fold (95% CI, 1.093–1.917, p = 0.010) higher risk of death. Sensitivity analyses confirmed the stability of the association. Moreover, RCS analysis revealed a positive non-linear relationship between SIRI and mortality (P for nonlinearity = 0.021).ConclusionHigh SIRI level at admission was significantly and positively associated with an increased risk of death, suggesting that SIRI may be an independent predictor of mortality in older patients with hip fracture.

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“…Monocytes/macrophages also participate in removing apoptotic cells and tissue debris, contributing to the resolution of inflammation. Due to the diverse functions that monocytes or macrophages perform during the development of inflammation and regulation of the coagulation cascade and tissue regeneration, dysregulation of their functions may affect coagulation disorders and thrombotic diseases such as Deep Vein Thrombosis (DVT) [ 74 , 89 , 90 ] and Pulmonary Embolism (PE) [ 90 , 91 ], Arterial Thrombosis [ 92 , 93 ], Disseminated Intravascular Coagulation (DIC) [ 94 ], Antiphospholipid Syndrome (APS) [ 95 , 96 ], or Thrombotic Microangiopathies [ 97 , 98 ], highlighting the importance of understanding their interaction with the coagulation system ( Table 2 ).…”

Section: Blood Coagulation Process and The Role Of Immune System Cellsmentioning

confidence: 99%

The Crossroads of the Coagulation System and the Immune System: Interactions and Connections

Wilhelm

Mertowska

Mertowski

et al. 2023

IJMS

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The coagulation and immune systems, two vital systems in the human body, share intimate connections that fundamentally determine patient health. These systems work together through several common regulatory pathways, including the Tissue Factor (TF) Pathway. Immune cells expressing TF and producing pro-inflammatory cytokines can influence coagulation, while coagulation factors and processes reciprocally impact immune responses by activating immune cells and controlling their functions. These shared pathways contribute to maintaining health and are also involved in various pathological conditions. Dysregulated coagulation, triggered by infection, inflammation, or tissue damage, can result in conditions such as disseminated intravascular coagulation (DIC). Concurrently, immune dysregulation may lead to coagulation disorders and thrombotic complications. This review elucidates these intricate interactions, emphasizing their roles in the pathogenesis of autoimmune diseases and cancer. Understanding the complex interplay between these systems is critical for disease management and the development of effective treatments. By exploring these common regulatory mechanisms, we can uncover innovative therapeutic strategies targeting these intricate disorders. Thus, this paper presents a comprehensive overview of the mutual interaction between the coagulation and immune systems, highlighting its significance in health maintenance and disease pathology.

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Association Between Monocyte Count and Preoperative Deep Venous Thrombosis in Older Patients with hip Fracture: A Retrospective Study

Cited by 5 publications

References 36 publications

Monocyte recruitment in venous pulmonary embolism at time of cancer diagnosis in upper gastrointestinal cancer patients

Monocyte recruitment in venous pulmonary embolism at time of cancer diagnosis in upper gastrointestinal cancer patients

Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study

The Crossroads of the Coagulation System and the Immune System: Interactions and Connections

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