Association Between Mitochondrial Function and Rehabilitation of Parkinson's Disease: Revealed by Exosomal mRNA and lncRNA Expression Profiles

Wang, Yixuan; Liu, Yonghong; Jin, Zhaohui; Liu, Cui; Yu, Xin; Chen, Keke; Meng, Detao; Liu, Aixian; Fang, Boyan

doi:10.3389/fnagi.2022.909622

Cited by 6 publications

(6 citation statements)

References 51 publications

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“…NDUFB7, which encodes reduced nicotinamide adenine dinucleotide ubiquitin oxidoreductase (Complex I), is positively correlated with the three lncRNAs. These are markers related to mitochondrial respiration and may be a potential biomarker to evaluate the effect of mitochondrial function recovery in PD rehabilitation 208 . These findings provided valuable potential biomarkers for evaluating future treatment strategies for PD.…”

Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 95%

“…These are markers related to mitochondrial respiration and may be a potential biomarker to evaluate the effect of mitochondrial function recovery in PD rehabilitation. 208 These findings provided valuable potential biomarkers for evaluating future treatment strategies for PD. Overexpression of TNF‐α and IL‐1β in serum exosomes of PD patients directly induced dopaminergic neuron death.…”

Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 95%

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Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally secreted by cells into body fluids. They are derived from endosomes and are wrapped in lipid membranes. Exosomes are involved in intracellular metabolism and intercellular communication. They contain nucleic acids, proteins, lipids, and metabolites from the cell microenvironment and cytoplasm. The contents of exosomes can reflect their cells’ origin and allow the observation of tissue changes and cell states under disease conditions. Naturally derived exosomes have specific biomolecules that act as the “fingerprint” of the parent cells, and the contents changed under pathological conditions can be used as biomarkers for disease diagnosis. Exosomes have low immunogenicity, are small in size, and can cross the blood–brain barrier. These characteristics make exosomes unique as engineering carriers. They can incorporate therapeutic drugs and achieve targeted drug delivery. Exosomes as carriers for targeted disease therapy are still in their infancy, but exosome engineering provides a new perspective for cell‐free disease therapy. This review discussed exosomes and their relationship with the occurrence and treatment of some neuropsychiatric diseases. In addition, future applications of exosomes in the diagnosis and treatment of neuropsychiatric disorders were evaluated in this review.

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Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 95%

Section: Exosomes In Neuropsychiatric Disordersmentioning

confidence: 95%

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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“…After the patients were enrolled in the group to complete the basic assessment, a two-week multidisciplinary rehabilitation was conducted, as described in detail in the preface report [33,34]. Using C-MiLL (Motekforcelink, Culemburg, Netherlands) and Balance Tutor (Meditouch, Netanya, Israel), the procedure entails (1) one-on-one physical therapy (2) balance and gait training (3) lower extremity strength training and aerobic exercise (4) speech therapy and health planning All sessions were conducted by an experienced rehabilitation team.…”

Section: Rehabilitation Protocolmentioning

confidence: 99%

Circular RNAs in Parkinson’s Disease: Reliable Biological Markers and Targets for Rehabilitation

et al. 2023

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In clinical practice, the underlying pathogenesis of Parkinson's disease (PD) remains unknown. Circular RNAs (circRNAs) have good biological properties and can be used as biological marker. Rehabilitation as a third treatment alongside drug and surgical has been shown to be clinically effective, but biomarkers of rehabilitation e ciency at genetic level is still lacking. In this study we identi ed differentially expressed circRNAs in peripheral blood exosomes between PD patients and health controls (HCs) and determined whether these circRNAs changed after rehabilitation, to explore the competing RNA networks and epigenetic mechanisms affected. We found that there were 558 upregulated and 609 downregulated circRNAs in PD patients compared to HCs, 3398 upregulated and 479 downregulated circRNAs in PD patients after rehabilitation compared to them before rehabilitation, along with 3721 upregulated and 635 downregulated circRNAs in PD patients after rehabilitation compared to HCs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that differentially expressed circRNAs may affect the stability of the cellular actin backbone and synaptic structure by in uencing the aggregation of α-Synuclein (a-syn). We selected two circRNAs overexpressed in PD patients for validation (hsa_circ_0001535 and hsa_circ_0000437), the results revealed that their expression levels were all reduced to varying degrees (p < 0.05) after rehabilitation. After network analysis, we believe that hsa_circ_0001535 may be related to the aggregation of a-syn, while hsa_circ_0000437 may act on hsa-let-7b-5p or hsa-let-7c-5p through sponge effect to cause in ammatory response. Our ndings suggest that rehabilitation can mitigate the pathological process of PD by epigenetic means.

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Section: Rehabilitation Protocolmentioning

confidence: 99%

Circular RNAs in Parkinson’s Disease: Reliable Biological markers and targets for Rehabilitation

Duan

Wang

Liu

et al. 2022

Preprint

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In clinical practice, the underlying pathogenesis of Parkinson’s disease (PD) remains unknown. Circular RNAs (circRNAs) have good biological properties and can be used as biological marker. Rehabilitation as a third treatment alongside drug and surgical has been shown to be clinically effective, but biomarkers of rehabilitation efficiency at genetic level is still lacking. In this study we identified differentially expressed circRNAs in peripheral blood exosomes between PD patients and health controls (HCs) and determined whether these circRNAs changed after rehabilitation, to explore the competing RNA networks and epigenetic mechanisms affected. We found that there were 558 upregulated and 609 downregulated circRNAs in PD patients compared to HCs, 3398 upregulated and 479 downregulated circRNAs in PD patients after rehabilitation compared to them before rehabilitation, along with 3721 upregulated and 635 downregulated circRNAs in PD patients after rehabilitation compared to HCs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that differentially expressed circRNAs may affect the stability of the cellular actin backbone and synaptic structure by influencing the aggregation of α-Synuclein (a-syn). We selected two circRNAs overexpressed in PD patients for validation (hsa_circ_0001535 and hsa_circ_0000437), the results revealed that their expression levels were all reduced to varying degrees (p < 0.05) after rehabilitation. After network analysis, we believe that hsa_circ_0001535 may be related to the aggregation of a-syn, while hsa_circ_0000437 may act on hsa-let-7b-5p or hsa-let-7c-5p through sponge effect to cause inflammatory response. Our findings suggest that rehabilitation can mitigate the pathological process of PD by epigenetic means.

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Association Between Mitochondrial Function and Rehabilitation of Parkinson's Disease: Revealed by Exosomal mRNA and lncRNA Expression Profiles

Cited by 6 publications

References 51 publications

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Circular RNAs in Parkinson’s Disease: Reliable Biological Markers and Targets for Rehabilitation

Circular RNAs in Parkinson’s Disease: Reliable Biological markers and targets for Rehabilitation

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