Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections

Marchini, Sergio; Cavalieri, Duccio; Fruscio, Robert; Calura, Enrica; Garavaglia, Daniela; Nerini, Ilaria Fuso; Mangioni, Costantino; Cattoretti, Giorgio; Clivio, Luca; Beltrame, Luca; Katsaros, Dionyssios; Scarampi, Luca; Menato, Guido; Perego, Patrizia; Chiorino, Giovanna; Buda, Alessandro; Romualdi, Chiara; D’Incalci, Maurizio

doi:10.1016/s1470-2045(11)70012-2

Cited by 171 publications

(150 citation statements)

References 33 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…In the present study, we focused on miR-214, which displays complex and contrary behavior in ovary cancers. miR-214 is overexpressed in ovary cancers and significantly associated with high grade and late/metastatic tumor stages, as well as with overall and progression free survival and post-surgical/chemotherapy recurrence [17,26,27]. However, miR-214 down-regulation has also been reported in neoplastic, as compared with normal ovaries, as well as in ovary cancer-derived effusions as compared with primary tumors [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

Zhang

2017

Bioscience Reports

View full text Add to dashboard Cite

Correspondence: Shuxiang Zhang (zhang sx19@163.com) Ovarian cancer is one of the leading causes of death among gynecological malignancies. Increasing evidence indicate that dysregulation of microRNAs (miRNAs) plays an important role in tumor radioresistance. The aim of the present study is to investigate whether microRNA-214 (miR-214) was involved in radioresistance of human ovarian cancer. Here, we showed that miR-214 was significantly up-regulated in ovarian cancer tissues and radioresistance ovarian cancer cell lines. Transfection of miR-214 agomir in radiosensitive ovarian cancer cell lines promoted them for resistance to ionizing radiation, whereas transfection of miR-214 antagomir in radioresistance ovarian cancer cell lines sensitized them to ionizing radiation again. Furthermore, we found miR-214 effectively promoted tumor radioresistance in xenograft animal experiment. Western blotting and quantitative real-time PCR demonstrated that miR-214 negatively regulated PTEN in radioresistance ovarian cancer cell lines and ovarian cancer tissues. Taken together, our data conclude that miR-214 contributes to radioresistance of ovarian cancer by directly targeting PTEN.

show abstract

Section: Discussionmentioning

confidence: 99%

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

Zhang

2017

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…In some tumors, up-or downregulation of miR-200c was correlated with poor outcome. For instance, downregulation of miR-200c was correlated with relapse in stage I epithelial ovarian cancers (16) and other tumors of the female reproductive organs (17). Likewise, a reduction of this miRNA correlated with a more aggressive behavior of non-small-cell lung cancer (18) whereas lung mesotheliomas or pancreatic carcinomas in contrast exhibit increased levels of miR-200c (19,20).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Sec23A Protein by miRNA-375 in Prostate Carcinoma

Szczyrba

Nolte²,

Wach³

et al. 2011

Molecular Cancer Research

108

View full text Add to dashboard Cite

Prostate carcinoma (CaP) is a leading cause of cancer-related death in men. We have previously determined the microRNA (miRNA) profile of primary CaP in comparison with nontumor prostate tissue. miRNAs are small, noncoding RNAs that inhibit protein synthesis on a posttranscriptional level by binding to the 3 0 -untranslated region (3 0 -UTR) of their target genes. In primary CaP tissue, we have previously found by miRNA sequencing that miR-375 and miR-200c were upregulated 9.1-and 4.5-fold, respectively. A computational analysis predicted the 3 0 -UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c. Here, we show that the 3 0 -UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells. In primary samples of CaP, we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c. The reduced levels of Sec23A protein were inversely correlated to the increased amount of miR-375 in the LNCaP and DU145 CaP cell lines when compared with normal prostate fibroblasts.

show abstract

“…Like this article, other three studies estimated the prognostic value of miRNA 200c expression in tumor tissue (Yu et al, 2010;Marchini et al, 2011;Karaayvaz et al, 2012). Among these studies, two studies reported HR and its 95% CI (Marchini et al, 2011;Toiyama et al, 2013) and the rest ones were processed by Matthew Sydes and Jayne Tierney's method to acquire survival data (Tierney et al, 2007;Marchini et al, 2011;Karaayvaz et al, 2012). HRs (high vs low) were pooled by fixedeffects model ( Figure 2B, …”

Section: Tissue Mirna 200c Expression and Survivalmentioning

confidence: 98%

How to Explain the Contradiction of microRNA 200c Expression and Survival in Solid Tumors?: a Meta-analysis

Wang

Shen²,

Jiang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections

Abstract: Nerina and Mario Mattioli Foundation, Cariplo Foundation (Grant Number 2010-0744), and the Italian Association for Cancer Research.

Cited by 171 publications

References 33 publications

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

Downregulation of Sec23A Protein by miRNA-375 in Prostate Carcinoma

How to Explain the Contradiction of microRNA 200c Expression and Survival in Solid Tumors?: a Meta-analysis

Contact Info

Product

Resources

About