Association Between Migraine and Celiac Disease: Results From a Preliminary Case-Control and Therapeutic Study

Gabrielli, Maurizio; Cremonini, Filippo; Fiore, Giuseppe; Addolorato, Giovanni; Padalino, C.; Candelli, Marcello; Leo, Mauro Di; Santarelli, Luca; Giacovazzo, M; Gasbarrini, Giovanni; Pola, Paolo; Gasbarrini, Antonio

doi:10.1111/j.1572-0241.2003.07300.x

Cited by 122 publications

(70 citation statements)

References 18 publications

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“…All were on a gluten-free diet. Recently, Gabrielli et al 26 demonstrated that a significant proportion of patients with migraine had subclinical CD and that their symptoms improved with a glutenfree diet. This is not the case in epileptic disorders or learning disabilities and ADHD.…”

Section: Discussionmentioning

confidence: 99%

Range of Neurologic Disorders in Patients With Celiac Disease

et al. 2004

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ABSTRACT. Objective. During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are insufficient data on the association of CD with various neurologic disorders in children, adolescents, and young adults, including more common and "soft" neurologic conditions, such as headache, learning disorders, attention-deficit/hyperactivity disorder (ADHD), and tic disorders. The aim of the present study is to look for a broader spectrum of neurologic disorders in CD patients, most of them children or young adults.Methods. Patients with CD were asked to fill in a questionnaire regarding the presence of neurologic disorders or symptoms. Their medical charts were reviewed, and those who were reported as having neurologic manifestations underwent neurologic examination and brain imaging or electroencephalogram if required. Their neurologic data were compared with that of a control group matched for age and gender.Results. Patients with CD were more prone to develop neurologic disorders (51.4%) in comparison with control subjects (19.9%). These disorders include hypotonia, developmental delay, learning disorders and ADHD, headache, and cerebellar ataxia. Epileptic disorders were only marginally more common in CD. In contrast, no difference was found in the prevalence of tic disorders in both groups. Therapeutic benefit, with gluten-free diet, was demonstrated only in patients with transient infantile hypotonia and migraine headache.Conclusion. This study suggests that the variability of neurologic disorders that occur in CD is broader than previously reported and includes "softer" and more common neurologic disorders, such as chronic headache, developmental delay, hypotonia, and learning disorders or ADHD. Future longitudinal prospective studies might better define the full range of these neurologic disorders and their clinical response to a gluten-free diet. Pediatrics 2004;113:1672-1676; celiac disease, neurologic disorders, migraine, attention-deficit/hyperactivity disorder, hypotonia.ABBREVIATIONS. CD, celiac disease; ADHD, attention-deficit/ hyperactivity disorder.A lthough in the past celiac disease (CD) was primarily considered to be a gluten enteropathy, during the past 2 decades, its clinical concept has been expanded, and it is now considered a multisystem autoimmune disorder, 1 with most of the patients being asymptomatic, oligosymptomatic, or present with extraintestinal manifestations. 2 Among these extraintestinal manifestations, there is a growing body of publications that report neurologic conditions that are associated with CD. 3-12 Although earlier studies reported neurologic complications in patients with classical gluten enteropathy, some recent studies report neurologic disorders in asymptomatic CD patients. 13,14 Most of the patients who have CD and were reported ...

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Section: Discussionmentioning

confidence: 99%

Range of Neurologic Disorders in Patients With Celiac Disease

et al. 2004

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“…The rest 2 groups almost showed neck to neck response rates. In a total of 32 patients who were followed up after a fortnight, 13 patients (41%) have shown > 50% improvement to treatment as depicted in Figure 3 ( 7,12,25,43) As shown in Figure 4, with increase in days of follow-up, response rates to treatment as well as number of patients both showed an increasing trend. But this change, of increase response to treatment is only noted with Group B and C. Among the 3 groups, Group C tops the list in terms of response rates after a period of 1 month.…”

Section: Discussion and Conclusion:-mentioning

confidence: 94%

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

MS¹

2017

IJAR

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Introduction: Over the years, there has been a dilemma regarding arriving at a diagnosis for headache pertaining to its variety of causes. One of the most common overlooked cause in the present day scenario for headache is GERD and Migraine. On day to day basis, we come across varied patient symptomatology which has indeed made us give a second thought to prescribe on management. Aim and Objective: To study if GERD and Migraine actually co-exist or they have a separate root cause for headache and also how change in lifestyle has an impact on health. Methodology: A study of random sample of 450 patients was conducted based on clinical evaluation for diagnosis and conservative management for the same was advised emphasising particularly on lifestyle modification. Results:The results drawn were compared by tabulating them into 3 groups with the two conditions taken as a separate entity and third when the two being mingled to conclude if interlink exists between the two conditions or purely is it a myth. Conclusion: Intermingling of GERD and Migraine was noted predominantly in our study rather than their separate existence.

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“…Given the protean clinical manifestations of CD and the expanding list of associated conditions, 24 the strategy of testing for CD for one associated symptom or condition may approach that of screening the general population, since nearly 100% of respondents may respond affirmatively to at least one item. For example, in the case finding study by Catassi, et al, 64% of all participants were eligible for CD testing, and this questionnaire did not include additional items that may be justifiably included in a CD symptom checklist, such as peripheral neuropathy, 25 migraines, 26 gastroesophageal reflux, 27 low bone density 28 and low levels of High-density lipoprotein. 29 A recent study set at a health fair in Caspar, Wyoming sheds light on the fine line between case finding and screening the general population.…”

Section: Identifying the Appropriate Patient To Test For Celiac Diseasementioning

confidence: 99%

Diagnosis of Celiac Disease

Tavakkoli

Lebwohl

2013

Clinical Gastroenterology

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Association Between Migraine and Celiac Disease: Results From a Preliminary Case-Control and Therapeutic Study

Abstract: Our results suggest that a significant proportion of patients with migraine may have CD, and that a gluten free diet may lead to a improvement in the migraine in these patients.

Cited by 122 publications

References 18 publications

Range of Neurologic Disorders in Patients With Celiac Disease

Range of Neurologic Disorders in Patients With Celiac Disease

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

Diagnosis of Celiac Disease

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