Association between microRNAs and chemoresistance in pancreatic cancer: Current knowledge, new insights, and forthcoming perspectives

Rahnama, Negin; Jahangir, Mohammadsaleh; Alesaeid, Samira; Kahrizi, Mohammad Saeed; Abilie, Ali; Mohammed, Rebar N.; Aslaminabad, Ramin; Akbari, Morteza; Özgönül, Ali

doi:10.1016/j.prp.2022.153982

Cited by 4 publications

(2 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Numerous human diseases are linked to dysregulated expression of miRNA. [3][4][5] Meanwhile, it was discovered that altered expression of numerous miRNAs played a significant role in the pathogenesis of numerous neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), traumatic brain injury (TBI), spinal cord injury (SCI), and Huntington's disease (HD). 6,7 The pathogenesis of excitotoxicity, apoptosis, oxidative stress, inflammation, neurogenesis, angiogenesis, and blood-brain barrier deficits is thought to be influenced by miRNAs.…”

Section: Introductionmentioning

confidence: 99%

“…MiRNAs can be released into extracellular fluids and carried to recipient cells by binding to proteins, such as Argonautes, or vesicles, such as exosomes 2 . Numerous human diseases are linked to dysregulated expression of miRNA 3–5 . Meanwhile, it was discovered that altered expression of numerous miRNAs played a significant role in the pathogenesis of numerous neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), traumatic brain injury (TBI), spinal cord injury (SCI), and Huntington's disease (HD) 6,7 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype

Shelash Al‐Hawary,

Yahya Ali,

Mustafa

et al. 2023

Biotechnology Progress

View full text Add to dashboard Cite

Altered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene‐based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion. Hence, the delivery of modified and unmodified miRNA molecules using excellent vehicles is required. In this light, mesenchymal stem cells (MSCs) have attracted increasing attention. The MSCs can be genetically modified to express or overexpress a particular microRNA aimed with promote neurogenesis and neuroprotection. The current review has focused on the therapeutic capabilities of microRNAs‐overexpressing MSCs to ameliorate functional deficits in neurological conditions.

show abstract