Association between metabolic syndrome and osteoporosis in Taiwanese middle-aged and elderly participants

Lin, Hsin-Hui; Huang, Chun-Yuan; Hwang, Lee-Ching

doi:10.1007/s11657-018-0467-z

Cited by 27 publications

(30 citation statements)

References 25 publications

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“…Therefore, it might not be a strong risk factor for osteoporosis in the Malaysian population. A retrospective study among Taiwanese population [n=2007, aged > 50 years] also reported no association between MetS and osteoporosis in both sexes [57]. In contrast, Chen et al [58] showed that both MetS and non-alcoholic fatty liver disease associated with it were positively associated with osteoporosis among postmenopausal women from Eastern China [n=938, aged 61.2 (SD 13.8) years].…”

Section: Discussionmentioning

confidence: 99%

Positive association between metabolic syndrome and bone mineral density among Malaysians

Chin¹,

Chan²,

Subramaniam³

et al. 2020

Int. J. Med. Sci.

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Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association between MetS and its components and bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA) among Malaysians. Methods: 400 Malaysians aged ≥ 40 years (52.5% women) residing in Klang Valley, Malaysia, were recruited. Subjects' demographic and lifestyle details were collected using a questionnaire, and blood pressure and body anthropometry were measured. Subjects' lumbar spine and total hip BMD were measured by DXA. Their fasting blood was collected for blood glucose level and lipid profile analysis. Regression analysis was used to analyze the relationship between MetS or its components and BMD. Results: Subjects with MetS had higher BMD compared to subjects without MetS in models unadjusted for BMI (spine p=0.008; hip p<0.001). This difference was attenuated with BMI adjustment (spine p=0.625; hip p=0.478). Waist circumference was associated positively with BMD in models unadjusted for BMI (spine p=0.012; hip p<0.001), but the association became negative with BMI adjustment (spine p=0.044; hip p=0.021). Systolic blood pressure was associated positively with total hip BMD (p=0.019) but BMI adjustment attenuated the relationship (p=0.080). Triglyceride level was associated with osteoporosis in a fully adjusted model (p=0.001). Overall, MetS was associated with osteoporosis (p=0.019) but lifestyle (p=0.188) and BMI adjustment attenuated the relationship (p=0.904). Conclusion: MetS is positively associated with BMD, and this relationship is predominantly mediated by BMI. Although MetS is not a significant risk factor for osteoporosis, the inverse relationship between waist circumference, a marker of central obesity, and BMD highlights the need to prevent adiposity to improve metabolic and skeletal health.

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Section: Discussionmentioning

confidence: 99%

Positive association between metabolic syndrome and bone mineral density among Malaysians

Chin¹,

Chan²,

Subramaniam³

et al. 2020

Int. J. Med. Sci.

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“…29 Multiple adjustments for confounders attenuated the relationship between MetS and bone health in both sexes. 29 Thus, the overall effects of MetS on bone are weak and inconsistent in both studies. 28,29 Two studies on the Caucasian populations showed that MetS protects bone health in women but not in men.…”

Section: Sex-specific Relationship Mets and Bone Mineral Densitymentioning

confidence: 99%

<p>Relationship Between Metabolic Syndrome and Bone Health – An Evaluation of Epidemiological Studies and Mechanisms Involved</p>

Chin¹,

Wong²,

Ekeuku³

et al. 2020

DMSO

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Metabolic syndrome (MetS) and osteoporosis are two medical problems plaguing the ageing populations worldwide. Though seemingly distinctive to each other, metabolic derangements are shown to influence bone health. This review summarises the relationship between MetS and bone health derived from epidemiological studies and explains the mechanistic basis of this relationship. The discourse focuses on the link between MetS and bone mineral density, quantitative sonometric indices, geometry and fracture risk in humans. The interesting sex-specific trend in the relationship, probably due to factors related to body composition and hormonal status, is discussed. Mechanistically, each component of MetS affects the bone distinctly, forming a complex interacting network influencing the skeleton. Lastly, the effects of MetS management, such as pharmacotherapies, exercise and bariatric surgery, on bone, are presented. This review aims to highlight the significant relationship between MetS and bone, and proper management of MetS with the skeletal system in mind could prevent cardiovascular and bone complications.

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“…In recent years, many studies reported that MetS was correlated with cardiovascular events (CVEs), Cancer, Psoriasis, Erectile Dysfunction, Osteoporosis and many other kinds of non-communicable diseases [10][11][12]. Among all this possible association, the major one was that MetS increased incidence of cardiovascular disease, coronary heart disease, and stroke [12][13][14]. CVD mortality had become the major mortality cause among elderly in recent years.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Cardiovascular Events in Elderly with Metabolic Syndrome from Rural Northeast China

Guo

et al. 2020

Preprint

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Background: Metabolic syndrome (MetS) had close relationship with cardiovascular events (CVEs). In the present study, among elderly with MetS, we intend to estimate the possible predictors of CVEs in order to prevent cardiovascular complications; among elderly without MetS, we aim to evaluate the possible risk factors for developing MetS in order to control it more effectively. Methods: In total 2869 elderly from rural China were enrolled. They took part in a physical examination and completed a questionnaire during 2012-2013 and were followed up during 2015-2017. Cox proportional hazards analysis was conducted to assess the possible predictors of CVEs and multivariate analysis was used to estimate the risk factors of newly diagnosed MetS. Results: Over a median follow-up of 4.66 years, 128 nonfatal or fatal cardiovascular events were documented and the cumulative incidence of MetS was 28.7% (36.3% for female; 24.3% for male). Cox proportional hazards analysis showed that family history of hypertension [Hazard ratio (HR): 1.694], current smoking (HR: 1.518), per 1 unit increase of systolic blood pressure (SBP) (HR: 1.016), and HDL-C (HR: 0.365) were strong predictors of newly onset CVEs among elderly with MetS at baseline. As for newly diagnosed MetS, male [Odd ratio (OR): 0.390] and proper sleep duration (8-9 hours/day) (OR: 0.580) served as protective factors. Furthermore, SBP (OR: 1.013), body mass index (OR: 1.178) and all lipid profiles were also associated factors of newly diagnosed MetS among elderly. Conclusions: Current smoking and relatively higher value of SBP, and HDL-C at baseline were correlated with higher possibility to have CVEs among elderly with MetS. In order not to develop MetS, elderly should pay more attention to metabolic parameters and have proper sleep duration.

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Association between metabolic syndrome and osteoporosis in Taiwanese middle-aged and elderly participants

Cited by 27 publications

References 25 publications

Positive association between metabolic syndrome and bone mineral density among Malaysians

Positive association between metabolic syndrome and bone mineral density among Malaysians

<p>Relationship Between Metabolic Syndrome and Bone Health – An Evaluation of Epidemiological Studies and Mechanisms Involved</p>

Predictors of Cardiovascular Events in Elderly with Metabolic Syndrome from Rural Northeast China

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