Association between metabolic syndrome and sensorineural hearing loss: a cross-sectional study of 11,114 participants

Aghazadeh-Attari, Javad; Mansorian, Behnam; Mirza-Aghazadeh-Attari, Mohammad; Ahmadzadeh, Jamal; Mohebbi, Iraj

doi:10.2147/dmso.s150893

Cited by 35 publications

(41 citation statements)

References 27 publications

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“…In addition, data from several large epidemiological and smaller cohort studies suggest a relationship between HL and MetS in the general population. [17][18][19][20][21] Microvascular damage has been reported in SNHL 22 and has also been found to be a complication of MetS in non-TS patients. 18 Therefore, MetS may be an associated risk factor for SNHL in adult patients with TS.…”

Section: Introductionmentioning

confidence: 99%

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Álvarez-Nava¹,

Racines-Orbe²,

Witt³

et al. 2020

TACG

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Background and purpose: Metabolic syndrome (MetS) is a disorder associated with an increased risk of cardiovascular disease. The frequency of each component of MetS in Turner syndrome (TS) subjects is high. An elevated incidence of hearing loss has also been reported in TS. Sensorineural hearing loss (SNHL) affects at least half of young women with TS. The association between MetS and SNHL has not been previously considered in TS. The aim of this study is to evaluate the association between these two conditions. Patients and Methods: Cross-sectional anthropometric, cardio-metabolic and audiological data were obtained from a cohort consisting of unrelated TS subjects (>20 years of age; n = 93). Metabolic syndrome was defined according to the International Diabetes Federation criteria. Types and severity of hearing loss were based on the American Speech Hearing Association guidelines. Results: Hearing loss was detected in 74% of ears from adult TS subjects and SNHL was observed in half of our TS subjects. The prevalence of MetS in TS subjects with or without SNHL was 64% and 11%, respectively (P < 0.05). After adjusting for age, MetS was related to a ninefold increase in the odds of SNHL. This odds increased in a stepwise manner as the number of MetS components increased. Conclusion: MetS and its individual components were associated factors for SNHL in TS subjects. A reduction in the number and severity of the components of MetS might potentially contribute to decreasing the progression of SNHL at younger ages, but further studies will be needed to explain the underlying pathological mechanism connecting MetS and SNHL.

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Section: Introductionmentioning

confidence: 99%

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Álvarez-Nava¹,

Racines-Orbe²,

Witt³

et al. 2020

TACG

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“…First of all, waist circumference, body weight or body mass index (BMi) were not analysed in the study. it is known that associations exist between obesity and Hl [21], and the relationship between metabolic syndrome in children and adolescents and cardiovascular diseases, diabetes and atherosclerosis has been confirmed in clinical studies. Moreover, it could be interesting to evaluate the prevalence of Hl in patients with metabolic syndrome not only with hypertension.…”

Section: Limitations Of the Studymentioning

confidence: 89%

Influence of coexisting internal diseases on hearing loss in patients over 50 years of age

Swidziński¹,

Frankowska²,

Małaczyńska³

et al. 2020

fmpcr

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Background. Presbyacusis is a physiological hearing defect progressing with age, caused by degenerative changes in the inner ear. chronic internal diseases can change the development of age-related hearing loss. Objectives. the aim of the study was to determine the influence of chronic internal diseases (hypertension, diabetes, hyperlipidaemia) on the process of hearing loss in people over 50 years of age. Material and methods. 215 audiological patients with hearing loss and internal disease were compared with 80 patients with physiological hearing loss (presbyacusis). we analysed the results of hearing thresholds in the pure tone audiometry. the results were analysed in four age groups: 50-59, 60-69, 70-79 and 80+. Results. the relation between internal chronic diseases, different age groups and Hl for mean values of 1 kHz, 2 kHz, 4 kHz and 8 kHz frequencies showed that the greatest progression of hearing loss was caused by hypertension and diabetes. the most significant differences were found in the 50 to 59 age groups. Additional significant differences were observed in the 60-69 age range for hyperlipidaemia patients, but the significance level was smaller. Conclusions. each of the chronic internal diseases is distinguished by a progression of hearing loss in patients' lives after 50 years of age. diseases such as hypertension or diabetes or hyperlipidaemia cause a considerably faster progression of hearing loss in the earlier period of life of elderly patients. SummaryISSN 1734-3402, eISSN 2449-8580 this is an open Access article distributed under the terms of the creative commons Attribution-noncommercial-shareAlike 4.0 international (cc By-nc-sA 4.0). license (http://creativecommons.org/licenses/by-nc-sa/4.0/). Świdziński P, Frankowska A, Małaczyńska B, linkowska-Świdzińska k, Hashimoto A, Bilińska B, Maciejewska-szaniec z, kowal P, sekula A, Maciejewska B. influence of coexisting internal diseases on hearing loss in patients over 50 years of age. Fam Med Prim Care Rev 2020; 22(1): 71-74, doi: https://doi.

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“…[4][5][6][7] Metabolic syndrome (MetS), a constellation of several metabolic components, including abdominal obesity, high blood pressure, elevated fasting glucose, and dyslipidemia, has been suggested as an independent risk factor of HL. 8,9) In an observational study of Korean women in their 50s or older, high-frequency HL was more prevalent among people with MetS than those without MetS. 10) In a study of middle-aged Korean men and women, MetS was associated with both low-and high-frequency hearing impairment in males; although, only hyperglycemia was significantly associated with low-and high-frequency hearing impairment in females.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Metabolic Syndrome and Hearing Loss: Korea National Health and Nutritional Survey

et al. 2021

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Background: We aimed to evaluate the association between metabolic syndrome (MetS) and hearing loss (HL) in light of noise exposure in Korean middle-aged adults. Methods: Subjects were 10,356 adults (4,509 males, 5,847 females) aged 40-80 years, who completed audiometric tests and laboratory examinations as part of the Korea National Health and Nutrition Examination Survey between 2010 and 2012. MetS was defined according to the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP III) and International Diabetes Federation (IDF). Low-frequency HL was defined as pure tone averages >25 decibels (dB) at low frequencies (0.5, 1, and 2 kilohertz [kHz]). High-frequency HL was defined as pure tone averages >25 dB at high frequencies (3, 4, and 6 kHz). Odd ratios (OR) and 95% confidence intervals (CI) of MetS associated with each HL type were estimated using multiple logistic regression analysis after adjusting for covariates and taking into consideration sampling weight. Results: 38.1% and 28.6% met the MetS by NCEP III and IDF criteria, respectively. Prevalence of HL was 29.3% and 63.9% for low-and high-frequency HL, respectively. MetS defined by NCEP III was associated with higher risk of high-frequency HL (OR, 1.35; 95% CI, 1.05-1.73), while MetS by IDF criteria was not. The interaction by the noise exposure on the MetS and high-frequency HL was not significant (P-interaction=0.100). There was no association between MetS and low-frequency HL, regardless of applied diagnostic criteria for MetS. Conclusion: Our findings suggest MetS is associated with high-frequency HL in people with exposure to noise.

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Association between metabolic syndrome and sensorineural hearing loss: a cross-sectional study of 11,114 participants

Cited by 35 publications

References 27 publications

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

<p>Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome</p>

Influence of coexisting internal diseases on hearing loss in patients over 50 years of age

Relationship between Metabolic Syndrome and Hearing Loss: Korea National Health and Nutritional Survey

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