Association Between Metabolic Syndrome and Benign Prostate Hyperplasia

Abstract

Metabolic syndrome (MetS) is a highly prevalent complex disorder among adults worldwide which includes cardiovascular risk factors such as central obesity, insulin resistance, dyslipidemia and hypertension. MetS or its components are prevalent in patients with benign prostate hyperplasia (BPH), a common urogenital disorder of adult male with increasing age. This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2014 to June 2015 with a total of 100 subjects. Of these 50 patients of BPH attending the Department of Urology, Dhaka Medical College Hospital, Dhaka was taken as Group I and 50 age-matched apparently healthy adults was taken as Group II. According to the National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP III, 2005) criteria, components of MetS as fasting plasma glucose, serum triglyceride, serum HDL-C level, blood pressure, waist circumference were assessed and compared between groups by chi-square (x2) tests and unpaired student's 't' test as appropriate. A p value <0.05 at 95% CI was considered as significant. Metabolic Syndrome was significantly more common in BPH patients than that of healthy individuals (72% VS 38%, p=0.001). Mean±SD of fasting plasma glucose and serum triglycerides were significantly higher in Group I than that of Group II (5.7±0.6 mmol/l vs 5.13±0.97 mmol/l, p=0.001; and 191.3±33.9 mg/dl vs 159.2±45.5 mg/dl, p=0.001, respectively). Percentage of subjects having high blood pressure, high serum triglyceride and low serum HDL-C were significantly high in BPH patients (Group I) than that of healthy individuals of Group II (BP: 72% VS 44%, p=0.005, TG: 90% vs 54%, p=0.001, HDL-C: 72% VS 54%,p=0.001). Metabolic syndrome or its components are more common among patients with benign prostate hyperplasia. Routine investigations to detect MetS can be done to reduce the risk of cerebrovascular diseases, cardiovascular diseases and type 2 diabetes mellitus in BPH patients.Bangladesh J Med Biochem 2015; 8(2): 42-48

Age and Prostatic Volume: The Prognosis for Benign Prostatic Hyperplasia

“…Age, ethnicity, obesity, genetics, sex steroid hormones, modifiable lifestyle variables, and inflammation are known stimulators of morphological volumetric changes in the prostate gland. Age is one factor that might cause changes in the prostate gland 10 . In this study, we found significant results in the age range of 61-70 years and prostate volume of 30ml when comparing obese and non-obese patients.…”

Relationship Between Hypertension And Diabetes Mellitus Type 2 With Benign Prostate Hyperplasia In Mgr. Gabriel Manek Hospital Atambua

“…Benign prostate hyperplasia (BPH) is a focal enlargement of the peri-urethral region of the prostate seen in most aging men, which results in symptoms requiring clinical intervention in approximately onethird of men over the age of 60 years. 1 Currently, BPH is the fourth most prevalent disease in men aged >50 years. 2 In 2013, Indonesia has 9.2 million cases of BPH, most of them were suffered by men aged over 60 years.…”