Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state

Lerner, Phillip I.; Sharony, L.; Miodownik, Chanoch

doi:10.1016/j.clnesp.2017.11.011

Cited by 48 publications

(35 citation statements)

References 157 publications

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“…All identified 13 SRs examined cohort studies, six with the outcome dementia [148][149][150]152,153,155] (including three with the outcome Alzheimer's disease) [148,152,153] and eight with the outcomes cognition, cognitive impairment or cognitive decline [100,[145][146][147]149,151,154,156] using single or combinations of several neuropsychological tests.…”

Section: Results From Srs Of Cohort Studiesmentioning

confidence: 99%

“…Among the SRs with focus on cognition, six [100,[145][146][147]151,156] (two high, one medium, three low quality) included up to three intervention studies in their analyses. In total, nine studies were evaluated, reporting conflicting results: seven RCTs (two using multi-nutrient supplements) and two pre-post studies in very heterogeneous populations (adolescents, young adults, older ambulatory people with history of falling, healthy older people, nursing home residents).…”

Section: Results From Srs Of Rctsmentioning

confidence: 99%

“…Results 13 SRs (including eight MAs) [100,[145][146][147][148][149][150][151][152][153][154][155][156] on vitamin D and risk of dementia and/or cognitive decline were included in this analysis (Supplemental Tables S14-S17 and Figure S4). In addition, four Mendelian randomisation studies were considered [157][158][159][160].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.

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Section: Results From Srs Of Cohort Studiesmentioning

confidence: 99%

Section: Results From Srs Of Rctsmentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Maretzke¹,

Bechthold²,

Egert

et al. 2020

Nutrients

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“…Impairment of C18Cer biosynthesis underlies neurodegeneration and causes novel progressive myoclonus epilepsy in humans [22]. Vitamin D deficiency is associated with neurodegenerative diseases, such as Alzheimer's disease [24,25], dementia [26], and cognitive disturbances [27]. Therefore, it is plausible that C18Cer may link vitamin D deficiency to neurodegeneration disease [25].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 Supplementation Increases Long-Chain Ceramide Levels in Overweight/Obese African Americans: A Post-Hoc Analysis of a Randomized Controlled Trial

et al. 2020

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Sphingolipid metabolism plays a critical role in cell growth regulation, lipid regulation, neurodevelopment, type 2 diabetes, and cancer. Animal experiments suggest that vitamin D may be involved in sphingolipid metabolism regulation. In this study, we tested the hypothesis that vitamin D supplementation would alter circulating long-chain ceramides and related metabolites involved in sphingolipid metabolism in humans. We carried out a post-hoc analysis of a previously conducted randomized, placebo-controlled clinical trial in 70 overweight/obese African-Americans, who were randomly assigned into four groups of 600, 2000, 4000 IU/day of vitamin D 3 supplements or placebo for 16 weeks. The metabolites were measured in 64 subjects (aged 26.0 ± 9.4 years, 17% male). Serum levels of N-stearoyl-sphingosine (d18:1/18:0) (C18Cer) and stearoyl sphingomyelin (d18:1/18:0) (C18SM) were significantly increased after vitamin D 3 supplementation (ps < 0.05) in a dose-response fashion. The effects of 600, 2000, and 4000 IU/day vitamin D 3 supplementation on C18Cer were 0.44 (p = 0.049), 0.52 (p = 0.016), and 0.58 (p = 0.008), respectively. The effects of three dosages on C18SM were 0.30 (p = 0.222), 0.61 (p = 0.009), and 0.68 (p = 0.004), respectively. This was accompanied by the significant correlations between serum 25-hydroxyvitamin D 3 [25(OH)D] concentration and those two metabolites (ps < 0.05). Vitamin D 3 supplementations increase serum levels of C18Cer and C18SM in a dose-response fashion among overweight/obese African Americans.

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“…Hypovitaminosis D has been extensively associated with MDD in general population (for meta-analysis see (Ju et al, 2013) and for review see (Lerner et al, 2018)) and supplementing subjects with MDD has been found to improve depressive symptoms in another recent metaanalysis (Schefft et al, 2017). Patients with SZ are at higher risk of hypovitaminosis D (Belvederi Murri et al, 2013) and this association has been replicated in first episode psychosis in another recent meta-analysis (Firth et al, 2017) (for review see (Adamson et al, 2017)).…”

Section: Introductionmentioning

confidence: 97%

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Fond

Godin

Schürhoff

et al. 2018

Psychiatry Research

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Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state

Cited by 48 publications

References 157 publications

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review

Vitamin D3 Supplementation Increases Long-Chain Ceramide Levels in Overweight/Obese African Americans: A Post-Hoc Analysis of a Randomized Controlled Trial

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

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