Association Between Mechanical, Inflammatory, and Functional Complications of the Ileal Pouch: Another Chicken-Or-Egg Story

Response to Ianiro et al.

“…In a study of 111 pouch patients, DD was found in 78% of patients and was more common in chronic pouchitis patients compared with those without chronic pouchitis (83.3% vs 62.2%) (3). DD can be primary or secondary (4).Primary DD is believed to lead to faecal stasis and consequently contribute to dysbiosis and dysregulation of the pouch mucosal immune system, hence chronic pouchitis. In secondary DD, dyssynergia is because of chronic pouchitis.…”

A Targeted Approach to Managing Chronic Pouchitis: Incorporating Accurate Phenotyping of Pouchitis and Assessment for Coexisting Dyssynergic Defecation

“…In a study of 111 pouch patients, DD was found in 78% of patients and was more common in chronic pouchitis patients compared with those without chronic pouchitis (83.3% vs 62.2%) (3). DD can be primary or secondary (4).Primary DD is believed to lead to faecal stasis and consequently contribute to dysbiosis and dysregulation of the pouch mucosal immune system, hence chronic pouchitis. In secondary DD, dyssynergia is because of chronic pouchitis.…”