Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging

Abstract

[Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3±7.0 years, while it was 16.7±12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease. Correlations between ADC value and the lumbar T score, femoral neck T score, and duration of disease were insignificant. A negative correlation was observed between BMD and disease duration. [Conclusion] Diffusion-weighted imaging provides valuable results in osteoporosis but is not a suitable technique for evaluating BMD in patients with AS because of the local and systemic inflammatory effects in the musculoskeletal system. The common pathophysiology of atherosclerosis and osteoporosis plays an important role in the negative correlation observed between MPV and BMD in patients with AS.

Platelet Distribution Width and Mean Platelet Volume Are Not Correlated with the Disease Activity Indices of Ankylosing Spondylitis

“…Meanwhile, other previous study reported that PDW and MPV were not correlated with AS activity [21,22]. We assumed that the diverse confounding factors to affect PDW and MPV levels might result in these discrepancies [11][12][13][14][15][16][17][24][25][26].…”

“…However, previous studies regarding the clinical efficiency of PDW and MPV to reflect AS activity reported inconsistent results, and furthermore, they did not strictly control the confounding factors to affect PDW and MPV [18][19][20][21][22]. In this study, we investigated whether PDW and MPV can reflect disease activity indices of AS in patients without abnormal laboratory results or medical conditions to affect PDW and MPV levels.…”

Mean Platelet Volume and Immature Platelet Fraction in Autoimmune Disorders

“…Data from Bozan et al, in turn, showed no difference in MPV values of AS patients and healthy controls ( 25 ). In a report where AS patients were stratified in osteopenic or not, MPV values were higher in the former, suggesting a role for MPV in bone loss ( 26 ). Data from Yazici et al showed that MPV was significantly higher in patients with AS than controls; values were reduced by conventional or anti-TNF therapy.…”

Correlation between C-Reactive Protein to Albumin Ratio and Disease Activity in Patients with Axial Spondyloarthritis

“…Many studies have shown that the whole blood components including neutrophils, lymphocytes, monocytes, and platelets were correlated with systemic inflammation [8][9][10]. Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio (PLR) have been identified as new inflammatory markers and reported to be higher in axSpA patients and related to disease activity [11][12][13].…”