Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis

Kılıç, Sevilay; Reşorlu, Hatice; Işık, Selda; Oymak, Sibel; Akbal, Ayla; Hız, Meliha Merve; Öğretmen, Zerrin

doi:10.5114/ada.2017.67076

Cited by 26 publications

(18 citation statements)

References 29 publications

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“… 2 , 11 , 28 MPV and PDW are known as PLT activation indices, reflecting the PLT production rate and stimulation. 2 , 11 , 29 In the literature, there are contradictory results about the relationship between platelet activation markers and psoriasis. 2 , 27 , 29 , 30 In a study carried out in Korea, significantly higher MPV and PDW values were found in patients with psoriasis than in controls and a positive correlation was observed between MPV and PASI score.…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 11 , 29 In the literature, there are contradictory results about the relationship between platelet activation markers and psoriasis. 2 , 27 , 29 , 30 In a study carried out in Korea, significantly higher MPV and PDW values were found in patients with psoriasis than in controls and a positive correlation was observed between MPV and PASI score. 11 In contrast, Saleh et al 31 reported that there was no significant difference in MPV levels between patients with psoriasis and controls.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Şirin

Korkmaz

Erturan

et al. 2020

Anais Brasileiros de Dermatologia

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Background Psoriasis is a chronic systemic inflammatory disease frequently associated with serious comorbidities. Objectives To investigate the systemic inflammatory burden in psoriasis and to assess the correlation between traditional and novel inflammatory markers and the severity of the disease. Methods This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and 50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores, and laboratory results were analyzed and compared. Results Compared with the control group, the psoriatic patients had significantly higher high sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte, neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol levels (p < 0.05). No significant difference was found in procalcitonin, lymphocyte, monocyte, hemoglobin, red blood cell distribution width, platelet, mean platelet volume, platelet distribution width, lymphocyte-to-monocyte ratio, anti-cyclic citrullinated peptide, glucose, alanine aminotransaminase, blood urea nitrogen, creatinine, triglyceride, total cholesterol, and LDL cholesterol levels between the two groups (p > 0.05). The Psoriasis Area and Severity Index score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte ratio (p < 0.05). Study limitations This was a single-center study with relatively limited numbers of patients and controls. Conclusions The data show that high sensitivity C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, neutrophil-to-lymphocyte ratio, and monocyte to HDL cholesterol ratio can be used as markers of systemic inflammation in patients with psoriasis. Moreover, high sensitivity C-reactive protein, serum amyloid A, monocyte to HDL cholesterol ratio and lymphocyte-to-monocyte ratio are closely related to the Psoriasis Area and Severity Index score, and they may be regarded as objective indicators in determining the disease severity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Şirin

Korkmaz

Erturan

et al. 2020

Anais Brasileiros de Dermatologia

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“…Vaya et al indicated that there were higher RDW and CRP levels with Behçet's disease than in a group of controls. Studies on MPV have mainly concentrated on psoriasis …”

Section: Discussionmentioning

confidence: 99%

Evaluation of complete blood cell and inflammatory parameters in patients with alopecia areata: Their association with disease severity

İslamoğlu

Demirbaş

2019

J of Cosmetic Dermatology

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Background Alopecia areata (AA) is a chronic inflammatory disease characterized by non‐cicatricial hair loss. The cause of the disease is still unknown. It can appear at any age and occurs in 0.2% of the general population. Red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR), and the ratio of platelets to lymphocytes (PLR) have all been reported as inflammatory markers in recent studies. However, these parameters have not been investigated in AA patients. Aim We investigated the haematological and inflammatory parameters of AA and considered their association with disease severity. Patients/Methods One hundred and five patients with AA and 108 healthy controls were enrolled in the study. RDW, MPV, PCT, NLR, PLR, erythrocyte sedimentation rate (ESR), and C‐reactive protein (CRP) were studied retrospectively. Disease severity was evaluated by using the Severity of Alopecia Tool (SALT) score. Results There were no statistically significant differences between RDW, MPV, PCT, NLR, and PLR levels in AA patients and in healthy controls. Only the CRP values were significantly higher in the AA group. Conclusion Complete blood count (CBC) parameters are low‐cost tests that can be used to define inflammation levels in inflammatory diseases. Our study shows that CRP can be used as a marker in diagnosing AA.

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“…In a similar study, Kilic et al evaluated MPV in 247 individuals including 116 patients with psoriatic arthritis, 41 patients with psoriasis vulgaris, and 90 healthy controls and reported that MPV was higher in the patients with psoriatic arthritis and patients with psoriasis vulgaris compared to the controls. The authors noted that MPV can be a novel marker of psoriasis (14). Kim et al evaluated 176 patients with psoriasis and 101 healthy controls and reported that MPV was higher in the patients compared to the controls, particularly in those with a high PASI score.…”

Section: Discussionmentioning

confidence: 99%

Novel inflammatory markers in patients with psoriasis

Yavuz¹,

Yavuz²

2019

Eastern J Med

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Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis

Cited by 26 publications

References 29 publications

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Evaluation of complete blood cell and inflammatory parameters in patients with alopecia areata: Their association with disease severity

Novel inflammatory markers in patients with psoriasis

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