Association between maternal vitamin E status and alpha‐tocopherol levels in the newborn and colostrum

Ribeiro, Karla Danielly da Silva; Lima, Mayara Santa Rosa; Medeiros, Jeane Franco Pires; Rebouças, Amanda de Sousa; Dantas, Raquel Costa Silva; Bezerra, Danielle Soares; Osório, Mônica Maria; Dimenstein, Roberto

doi:10.1111/mcn.12232

Cited by 15 publications

(11 citation statements)

References 36 publications

(37 reference statements)

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“…In this sense, the recommended daily intake of vitamin E for Brazilian nursing women [32] is nearly half that recommended in North America by the Institute of Medicine [4,12]. The vitamin E status biomarker (serum α-tocopherol/cholesterol ratio; µmol/mmol) indicates that the prevalence of vitamin E deficiency (<2.25 µmol/mmol) [2,4] increased from 37 to 63% of the volunteers from early- to mid-lactation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to serving as retinoid precursors, these carotenoids are transferred to breast milk and, together with lycopene and lutein, might contribute to breastfed infant health, as they present potential bioactivity. The primary function of vitamin E is related to its activity as a potent free radical scavenger and, although overt signs of deficiency are rare, pre-term infants might be more susceptible to associated illnesses [2].…”

Section: Introductionmentioning

confidence: 99%

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Breast Milk Content of Vitamin A and E from Early- to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women

et al. 2019

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Our aims were to investigate vitamin A and E status during lactation and the determinants of breast milk content for the appropriate nutrition of the infant in a study with nursing Brazilian women. We hypothesized that both inadequate intake and the lipoprotein distribution of vitamin A and E during lactation could have an impact on their breast milk levels from early- to mid-lactation. Nineteen adult lactating women participated in this longitudinal observational study, in which dietary records, blood and mature breast milk samples were collected for the analysis of vitamin A and E, and carotenoids in early- (2nd to 4th week) and mid-lactation (12th to 14th week). Nutrient intake was balanced by the Multiple Source Method (MSM), and the intake of vitamin A and E was inadequate in 74 and 100% of the women, respectively. However, these results were not reflected in low serum concentrations of retinol and only 37% of the volunteers were vitamin E deficient according to the blood biomarker. As lactation progressed, vitamin A and E status worsened, and this was clearly observed by the decrease in their content in breast milk. The reduced content of vitamin A and E in the breast milk was not related to their distribution in lipoproteins. Taken together, the contents of vitamin A and E in breast milk seemed to be more sensitive markers of maternal nutrition status than respective blood concentrations, and dietary assessment by the MSM in early lactation was sensitive to indicate later risks of deficiency and should support maternal dietary guidance to improve the infant’s nutrition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breast Milk Content of Vitamin A and E from Early- to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women

et al. 2019

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“…Alpha-tocopherol and retinol ‬were ‬extracted ‬‬from ‬serum samples via our previously reported method with slight modification [22, 23]. In brief, ‬95% ethanol ‬and hexane ‬P.A (Merck, ‬Darmstadt, Germany) were ‬used ‬for ‬protein ‬precipitation ‬and ‬for ‬extraction, respectively.…”

Section: Methodsmentioning

confidence: 99%

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Miranda

Duarte

Cruz

et al. 2018

Journal of Nutrition and Metabolism

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Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n=177) aged 30–74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using the Friesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n=90), FI = 5–9 (n=50), and FI = 10–15 (n=37). Serum levels of vitamins were ‬determined via high-performance liquid chromatography and serum biochemical analysis. Results. Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals in this group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (n=0.492), and the low frequency of retinol was consistent among the FI groups (n=0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.

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“…Furthermore, most of the studies did not report mean BMI, ethnicity, educational level or per capita income. Only five studies 11,[31][32][33][34][35] reported on the participants' educational level, and showed that the majority had low levels (data not shown). Six studies 11,12,[32][33][34][35][36] reported on per capita income and showed that the majority of the participants had monthly per capita income of less than one minimum wage (data not shown).…”

Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

et al. 2021

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BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. REGISTRATION NUMBER IN PROSPERO: CRD42020221605.

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Association between maternal vitamin E status and alpha‐tocopherol levels in the newborn and colostrum

Cited by 15 publications

References 36 publications

Breast Milk Content of Vitamin A and E from Early- to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women

Breast Milk Content of Vitamin A and E from Early- to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

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