Association between maternal smoking, gender, and cleft lip and palate

Martelli, Daniella Reis Barbosa; Coletta, Ricardo D.; Oliveira, Eduardo A.; Swerts, Mário Sérgio Oliveira; Rodrigues, Liana Álvares; Oliveira, M. C.; Júnior, Hercílio Martelli

doi:10.1016/j.bjorl.2015.07.011

Cited by 35 publications

(37 citation statements)

References 25 publications

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“…They found that first trimester cigarette smoking increased the risk of cleft lip and cleft palate only in males, OR 1.431 (95% CI 1.241, 1.651), while male gender also appeared to be an independent risk factor for some types of congenital anomalies [19]. A strong association between male gender and the presence of cleft lip and/or palate (OR = 3.51; 95% CI 2.83-4.37) was also found by Strange et al [20].…”

Section: Gender-related Effects In Biology and In Teratology 41 Gendsupporting

confidence: 63%

“…Increased risk for cleft lip and cleft palate in males Bahado-Singh et al [19], Strange et al [20] Cocaine High risk for attention and inhibitory control problems, emotional modulation difficulties, health risk behaviors, and antisocial behavior in males Bennett et al [22,23] Alcohol Fetal alcohol syndrome disorder is more prevalent in young boys Thanh et al [24] Childhood mental health problems are more prevalent in girls Sayal et al [25] Endocrine disruptors Exposure to endocrine disruptors, especially substances with estrogenic or antiandrogenic affects, such as 2-ethylhexyl phthalate and bisphenol A, might adversely affect embryonic sex organ development Lambrot et al…”

Section: Cigarette Smokingmentioning

confidence: 99%

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Methods for Prenatal Sex Determination and Their Importance in Understanding and Prevention of Gender-Related Birth Defects

Ornoy¹,

Weinstein-Fudim²,

Ergaz³

2020

Childbirth

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Various hormones, chemicals, and teratogenic agents exhibit gender-related effects in utero as well as postnatally. Among such gender-specific teratogens are endocrine disruptors, especially phthalates that affect male gonads, diabetesinduced oxidative stress with more deleterious effects on male offspring, procarbazine-induced cleft palate affecting more male fetal rats compared to females, and VPA-induced autism-like behavior that affects differently males than females. Hence, there are many needs for the accurate determination of genetic gender. In newborn animals, the morphological methods that exist for sex determination (i.e., anogenital distance) are generally inaccurate. Hence, an accurate and simple method for the prenatal and early postnatal assessment of the genetic sex, prior to reliable evaluation from the external genitalia, is of utmost importance. Indeed, several methods have been developed for accurate assessment of genetic sex, which are discussed in this chapter. Findings from studies in our laboratory have shown that the method described by McFarlan et al. for the assessment of genetic sex in adult mice by PCR of Sly/Xlr genes can be reliably used for the genetic sex determination of any tissue, including embryos and fetuses, with an accuracy of about 100%.

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Section: Gender-related Effects In Biology and In Teratology 41 Gendsupporting

confidence: 63%

Section: Cigarette Smokingmentioning

confidence: 99%

Methods for Prenatal Sex Determination and Their Importance in Understanding and Prevention of Gender-Related Birth Defects

Ornoy¹,

Weinstein-Fudim²,

Ergaz³

2020

Childbirth

View full text Add to dashboard Cite

show abstract

“…6 Risk factors such as maternal smoking, maternal age, alcohol consumption, gender, medicinal drugs, viral infection and exposure to teratogens during early pregnancy have previously been investigated. [1][2][3][4][5][6][7] Researchers have proposed some other theories to explain the origin of CLP. Other associated factors are the antiepileptic drugs usage, maternal (toxoplasmosis, rubella, cytomegalovirus, herpes simplex TORCH) infections, nutritional deficiencies (especially folic acid) during pregnancy, and consanguineous marriage between the parents.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Disease has a major impact especially on the affected individual, their families and society that needs long rehabilitation between birth and adulthood. The effects on an individual's speech, hearing, appearance, social integration and psychology can lead to long-lasting adverse outcomes for health and wellbeing.…”

Section: 2mentioning

confidence: 99%

Cleft lip and cleft palate: a disease with multiple risk factors in a pregnant woman

Uçar

İlhan

Gül

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…They can be either unilateral or bilateral, complete, or incomplete (1,2). CLP represents a major public health problem due to the possible associated morbidity, multifactorial etiology, and the extensive multidisciplinary commitment required for intervention and management (3,4).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cad/Cam Nasoalveolar Molding Appliance on Correction of the Nasal Deformity in Complete Bilateral Cleft Lip and Palate

Hanno

Shimy

Habib

et al. 2020

Alexandria Dental Journal

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INTRODUCTION: Cleft lip and palate (CLP) affects about 1.5 per 1000 live births (250,000 new cases per year) worldwide. They can be either unilateral or bilateral, complete or incomplete. The bilateral cleft lip and palate (BCLP) deformity typically arises with a protrusive premaxilla. The nasal deformity includes deficient columella, with flared lateral alar cartilages which usually require additional surgeries to improve the nasal symmetry. NasoAlveolar Moulding (NAM) technique, aims to align the alveolus, lip, and nose properly; reduce the severity of the nasal deformity, and lengthen the columella without surgery. OBJECTIVES: The study aims to quantify the effect of NAM therapy, fabricated by CAD/CAM additive manufacturing, in the improvement of nasolabial deformity in terms of bialar width, columellar length and width in infants with complete BCLP. MATERIALS AND METHODS: Ten infants with non-syndromic BCLP (age < 1 month) were selected. Impressions were obtained. The casts obtained from the impressions were scanned using a 3D laser scanner. Designing and 3D printing of the appliances were completed. The appliances were inserted and retained using surgical tapes. Nasal stents were incorporated 60 days after the start of the treatment. Nasal measurements were obtained before treatment and at the end of treatment (after four months). RESULTS: Data was collected and statistically analyzed. After NAM therapy, there was a statistically significant increase in columellar length and a statistically significant decrease in both columellar width and bialar width. CONCLUSIONS: CAD/CAM PNAM therapy has proved its effectiveness in BCLP by showing an improvement in the columellar and bialar presurgical presentation. CAD/CAM PNAM therapy should be considered a routine procedure in the treatment protocol for BCLP.

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Association between maternal smoking, gender, and cleft lip and palate

Abstract: Our findings are consistent with a positive association between maternal smoking during pregnancy and CL/P in male gender. The results support the importance of smoking prevention and introduction of cessation programs among women with childbearing potential.

Cited by 35 publications

References 25 publications

Methods for Prenatal Sex Determination and Their Importance in Understanding and Prevention of Gender-Related Birth Defects

Methods for Prenatal Sex Determination and Their Importance in Understanding and Prevention of Gender-Related Birth Defects

Cleft lip and cleft palate: a disease with multiple risk factors in a pregnant woman

Effect of Cad/Cam Nasoalveolar Molding Appliance on Correction of the Nasal Deformity in Complete Bilateral Cleft Lip and Palate

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