Association between maternal multimorbidity and preterm birth, low birth weight and small for gestational age: a prospective birth cohort study from the Japan Environment and Children’s Study

Nakanishi, Kentaro; Saijo, Yasuaki; Yoshioka, Eiji; Sato, Yukihiro; Kato, Yasuhito; Nagaya, Ken; Takahashi, Satoru; Ito, Yoshiya; Kobayashi, Sumitaka; Miyashita, Chihiro; Ikeda‐Araki, Atsuko; Kishi, Reiko

doi:10.1136/bmjopen-2022-069281

Cited by 6 publications

(6 citation statements)

References 54 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, several recent studies have reported an increased risk of extreme PTB (<28 weeks) among women with obesity (BMI ≥ 30 kg/m 2 ) [37][38][39][40][41]. Furthermore, previous studies involving women of diverse ethnicities have indicated an association between obesity and extreme PTB [42][43][44]. Shaw et al conducted a comprehensive analysis of the link between prepregnancy BMI and sPTB in a large population-based cohort.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Spontaneous Preterm Birth after Ultrasound-Indicated Cerclage

Lee,

Yun,

Park

et al. 2023

JPM

View full text Add to dashboard Cite

Ultrasound-indicated cerclage (UIC) is recommended to prevent spontaneous preterm birth (sPTB) in women with a short cervix at mid-trimester and a history of PTB. We assessed the factors related to sPTB after UIC and determined the corresponding risks. This retrospective cohort study was conducted at a university hospital. UIC was performed between 15 and 26 weeks of gestation in women with a cervical length of <2.5 cm. Univariate and multivariate analyses were used to examine factors associated with sPTB after UIC. An earlier gestational age and shorter cervical length at UIC were associated with sPTB after UIC. While PTB history was not associated with an increased risk of sPTB, it did increase the risk of repeat cerclage after UIC. Higher levels of preoperative serum inflammatory markers and obesity significantly increased the risk of sPTB after UIC. These findings provide helpful guidance for patient counseling and management in predicting the delivery timing after UIC in women with a short cervix in the mid-trimester.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Associated with Spontaneous Preterm Birth after Ultrasound-Indicated Cerclage

Lee,

Yun,

Park

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…Recently, Naksini K et al published the first paper investigating the association between maternal multimorbidity and perinatal outcomes [ 10 ]. Their study reported a lower prevalence of multimorbidity (6.3%) compared to ours and to previous studies [ 4 , 28 ], which can be attributed to differences in the definition of multimorbidity.…”

Section: Discussionmentioning

confidence: 99%

“…However, the impact of multimorbidity on maternal and pregnancy outcomes is poorly understood as most research has focused on individual maternal diseases to date. There is limited knowledge on the prevalence [ 5 , 6 ], causes and consequences of multimorbidity during pregnancy on maternal and birth, and neonatal outcomes [ 7 – 10 ]. One recent paper has reported an association between maternal multimorbidity and preterm birth (PTB) and other adverse perinatal outcomes [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study

Azcoaga-Lorenzo,

Fagbamigbe,

Agrawal

et al. 2023

BMC Med

View full text Add to dashboard Cite

Background Multimorbidity is common in women across the life course. Preterm birth is the single biggest cause of neonatal mortality and morbidity. We aim to estimate the prevalence of multimorbidity in pregnant women and to examine the association between maternal multimorbidity and PTB. Methods This is a retrospective cohort study using electronic health records from the Scottish Morbidity Records. All pregnancies among women aged 15 to 49 with a conception date between 1 January 2014 and 31 December 2018 were included. Multimorbidity was defined as the presence of two or more pre-existing long-term physical or mental health conditions, and complex multimorbidity as the presence of four or more. It was calculated at the time of conception using a predefined list of 79 conditions published by the MuM-PreDiCT consortium. PTB was defined as babies born alive between 24 and less than 37 completed weeks of gestation. We used Generalised Estimating Equations adjusted for maternal age, socioeconomic status, number of previous pregnancies, BMI, and smoking history to estimate the effect of maternal pre-existing multimorbidity. Absolut rates are reported in the results and tables, whilst Odds Ratios (ORs) are adjusted (aOR). Results Thirty thousand five hundred fifty-seven singleton births from 27,711 pregnant women were included in the analysis. The prevalence of pre-existing multimorbidity and complex multimorbidity was 16.8% (95% CI: 16.4–17.2) and 3.6% (95% CI: 3.3–3.8), respectively. The prevalence of multimorbidity in the youngest age group was 10.2%(95% CI: 8.8–11.6), while in those 40 to 44, it was 21.4% (95% CI: 18.4–24.4), and in the 45 to 49 age group, it was 20% (95% CI: 8.9–31.1). In women without multimorbidity, the prevalence of PTB was 6.7%; it was 11.6% in women with multimorbidity and 15.6% in women with complex multimorbidity. After adjusting for maternal age, socioeconomic status, number of previous pregnancies, Body Mass Index (BMI), and smoking, multimorbidity was associated with higher odds of PTB (aOR = 1.64, 95% CI: 1.48–1.82). Conclusions Multimorbidity at the time of conception was present in one in six women and was associated with an increased risk of preterm birth. Multimorbidity presents a significant health burden to women and their offspring. Routine and comprehensive evaluation of women with multimorbidity before and during pregnancy is urgently needed.

show abstract

“…For example, a cross-sectional study among the UK population estimated that the prevalence of coexisting multiple chronic conditions ranged from 19.8% to 46.2% in pregnant women and was associated with higher odds of preterm birth (adjusted odds ratio (aOR) = 1.64; 95% confidence interval (CI) = 1.48–1.82) [ 13 , 14 ]. Similarly, maternal multimorbidity was found to associate with preterm birth, low birthweight, and small for gestational age according to a study conducted in Japan [ 16 ]. Another study from India expanded the spectrum of MHFP by including maternal risks, lifestyle risks, medical risks, current health risks, and previous birth outcome risks, and found that 16.4% of the women in the study population had two or more high-risk factors simultaneously [ 18 ].…”

mentioning

confidence: 99%

Burden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study

Zhang,

Ding,

Dai

et al. 2024

J Glob Health

View full text Add to dashboard Cite

Association between maternal multimorbidity and preterm birth, low birth weight and small for gestational age: a prospective birth cohort study from the Japan Environment and Children’s Study

Cited by 6 publications

References 54 publications

Factors Associated with Spontaneous Preterm Birth after Ultrasound-Indicated Cerclage

Factors Associated with Spontaneous Preterm Birth after Ultrasound-Indicated Cerclage

Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study

Burden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study

Contact Info

Product

Resources

About