Association between maternal exposure to tobacco, presence of TGFA gene, and the occurrence of oral clefts. A case control study

Junaid, Mohammed; Narayanan, M B Aswath; Jayanthi, D. Deva; Kumar, S G Ramesh; Selvamary, A. Leena

doi:10.1007/s00784-017-2102-6

Cited by 12 publications

(13 citation statements)

References 31 publications

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“…Paternal smoking was evaluated in a subset of the current data from Vietnam, the Philippines, Morocco, and Honduras (n = 626 father/child duos) and no association with cleft was found [ 32 ]. Studies in Norway [ 33 ], India [ 34 ], and China [ 35 ] have found that exposure to ETS, defined as an exposure to passive tobacco smoke during the first trimester at home or work, is associated with an increased risk of cleft (OR = 1.6, 95% CI = 1.0-2.5; OR = 2.0, 95% CI = 1.2-3.4; OR = 2.46, 95% CI = 0.99-6.08, respectively), however a case-control study based in a large American birth defect registry found no effect [ 31 ]. Our study did not see an effect of either paternal smoking or ETS, where ETS is defined as maternal report of passive smoke exposure in the home during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

Auslander

McKean‐Cowdin

Brindopke

et al. 2020

Journal of Global Health

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Background Cleft is one of the most common birth defects globally and the lack of access to surgery means millions are living untreated. Smoke exposure from cooking occurs infrequently in developed countries but represents a high-proportion of smoke exposure in less-developed regions. We aimed to study if smoke exposure from cooking is associated with an increased risk in cleft, while accounting for other smoke sources. Methods We conducted a population-sampled case-control study of children with cleft lip and/or palate and healthy newborns from Vietnam, Philippines, Honduras, Nicaragua, Morocco, Congo, and Madagascar. Multivariable regression models were used to assess associations between maternal cooking during pregnancy, parental smoking, and household tobacco smoke with cleft. Results 2137 cases and 2014 controls recruited between 2012-2017 were included. While maternal smoking was uncommon (<1%), 58.3% case and 36.1% control mothers cooked over an open fire inside. Children whose mothers reported cook smoke exposure were 49% (95% confidence interval (CI) = 1.2-1.8) more likely to have a child with a cleft. This was consistent in five of seven countries. No significant associations were found for any other smoke exposure. Conclusions Our finding of maternal cook smoke and cleft in low-resource countries, similar to maternal tobacco smoke in high-resource countries, may reflect a common etiology. This relationship was present across geographically diverse countries with variable socioeconomic statuses and access to care. Exposures specific to low-resource settings must be considered to develop public health strategies that address the populations at increased risk of living with cleft and inform the mechanisms leading to cleft development.

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Section: Discussionmentioning

confidence: 99%

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

Auslander

McKean‐Cowdin

Brindopke

et al. 2020

Journal of Global Health

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“…It is expressed in the MEE cells during palatal fusion (Ebadifar et al, 2016; Mitchell, 1997; Vieira & Orioli, 2001), and is known to regulate extracellular matrix synthesis and mesenchymal migration in palatal cultures (Ebadifar et al, 2016; Holder, Vintiner, Farren, Malcolm, & Winter, 1992; Machida et al, 1999; Qian, Feingold, Stoll, & May, 1993; Shiang et al, 1993). Variants effecting TGFA ‐smoking GxE have been observed in several populations (Ebadifar et al, 2016; Hwang et al, 1995; Junaid, Narayanan, Jayanthi, Kumar, & Selvamary, 2018; Maestri et al, 1997; G. M. Shaw et al, 1996; Sull et al, 2009). TGFB3 encodes a ligand that regulates TGF‐β signaling which is critical for lip and palatal development (Reynolds et al, 2020; in this issue).…”

Section: Behavioral Risk Factors For Ofcsmentioning

confidence: 99%

Environmental mechanisms of orofacial clefts

Garland

Reynolds

Zhou

2020

Birth Defects Research

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Orofacial clefts (OFCs) are among the most common birth defects and impart a significant burden on afflicted individuals and their families. It is increasingly understood that many nonsyndromic OFCs are a consequence of extrinsic factors, genetic susceptibilities, and interactions of the two. Therefore, understanding the environmental mechanisms of OFCs is important in the prevention of future cases. This review examines the molecular mechanisms associated with environmental factors that either protect against or increase the risk of OFCs. We focus on essential metabolic pathways, environmental signaling mechanisms, detoxification pathways, behavioral risk factors, and biological hazards that may disrupt orofacial development.

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“…Researchers found a strong association between orofacial clefts and family history (Figueiredo et al, 2015) and the literature suggests that family history is a strong component to be considered in predicting the potential risk of new cases of orofacial clefts in the family. Moreover, this factor may be associated with an increased risk of occurrence of cleft in the family (Junaid et al, 2018; Leite & Koifman, 2009; Li et al, 2016; Lin et al, 2014; Mbuyi‐Musanzayi et al, 2018). Studies have shown that the risk of occurrence of clefts in families of individuals already affected can be 4.6–8.2 times greater than what occurs in the general population (Acuña‐González et al, 2011; Salihu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, this factor may be associated with an increased risk of occurrence of cleft in the family (Junaid et al, 2018;Leite & Koifman, 2009;Li et al, 2016;Lin et al, 2014;Mbuyi-Musanzayi et al, 2018).…”

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confidence: 99%

Family history in non‐syndromic orofacial clefts: Is there a pattern?

et al. 2021

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Objective To survey the frequency and pattern of family history for non‐syndromic orofacial clefts (NSOFC). Initial hypothesis: more complex forms have a higher frequency of positive family history. Materials and Methods A retrospective study was carried with 2,668 subjects with three different types of clefts (CL Group (cleft lip), CLP Group (cleft lip and palate), and CP group (cleft palate)); family history information was collected. The Chi‐square (X2) and Z‐test were used. Results A positive family history was found in 31% of the sample. The CLP Group had highest percentage and highest proportion of affected relatives, being these factors statistically significant when compared to the CP Group. Comparisons between the CLP Male and CL Male with CP Male were statistically significant. First‐degree kinship was the most frequently found. Conclusions The initial hypothesis was confirmed, subjects with CLP had the highest percentage of positive family history, the highest proportion of affected relatives and had more affected relatives in comparison with CP. It is more common to find affected relatives in the CLP Male and CL Male groups when compared with CP Male. CLP and CP groups present a pattern of occurrence of the type of cleft in the family.

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Association between maternal exposure to tobacco, presence of TGFA gene, and the occurrence of oral clefts. A case control study

Abstract: The study has brought into forth the role of passive smoking in the development of oral clefts thereby warranting an effective public health policy to tackle the same.

Cited by 12 publications

References 31 publications

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

Environmental mechanisms of orofacial clefts

Family history in non‐syndromic orofacial clefts: Is there a pattern?

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