Association between maternal diabetes mellitus and the risk of congenital malformations: A meta-analysis of cohort studies

Zhao, Enfa; Zhang, Yafei; Zeng, Xianling; Li, Baomin

doi:10.5582/ddt.2015.01044

Cited by 42 publications

(44 citation statements)

References 39 publications

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“…That expectation is based on the known teratogenic effect of pre-GDM and the fact that nearly 50% of the women in this cohort were diagnosed as T2DM at the time of screening and had received no treatment early in pregnancy [29]. Nevertheless, this estimate is associated with uncertainties such as the unknown sensitivity of the mid-trimester ultrasound scan in any center in Saudi Arabia for the detection of structural abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)

Wahabi

Fayed

Esmaeil

et al. 2017

BioMed Research International

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The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among the Saudi pregnant population. In this subcohort, we compared the maternal and the neonatal outcomes of diabetic women with pre-GDM and GDM to the outcomes of nondiabetic mothers who delivered during the same period. From the total cohort, 9723 women participated in this study. Of the participants, 24.2% had GDM, 4.3% had pre-GDM, and 6951 were nondiabetic. After adjustment for confounders, women with GDM had increased odds of delivering a macrosomic baby (OR: 1.6; 95% CI: 1.2–2.1). Women with pre-GDM were more likely to deliver by Cesarean section (OR: 1.65; CI: 1.32–2.07) and to have preterm delivery < 37 weeks (OR: 2.1; CI: 1.5–2.8). Neonates of mothers with pre-GDM were at increased risk of being stillbirth (OR: 3.66; CI: 1.98–6.72), at increased risk of admission to NICU (OR: 2.21; CI: 1.5–3.27), and at increased risk for being macrosomic (OR: 2.40; CI: 1.50–3.8). The prevalence of GDM and pre-GDM in the Saudi pregnant population is among the highest in the world. The conditions are associated with high maternal and neonatal morbidities and mortalities.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)

Wahabi

Fayed

Esmaeil

et al. 2017

BioMed Research International

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“…Die bei Kindern diabetischer Mütter beobachtete höhere Fehlbildungsrate trägt wesentlich zur erhöhten perinatalen Mortalität bei [6,7]. Während bei prägravidem Diabetes mellitus eine deutlich erhöhte Fehlbildungsrate zu verzeichnen ist, ist diese bei Schwangeren mit Gestationsdiabetes allenfalls geringfügig erhöht [8,9]. Dies dürfte darauf zurückzuführen sein, dass bei einer Reihe von (insbesondere adipösen) Frauen erstmalig in der Schwangerschaft eine gestörte Glukosetoleranz diagnostiziert und als Gestationsdiabetes eingeordnet wurde, bei denen bereits perikonzeptionell eine (nicht entdeckte) gestörte Glukosetoleranz bestand [10].…”

Section: Diabetische Embryopathieunclassified

Betreuung von Neugeborenen diabetischer Mütter. Leitlinie der GNPI, DGPM, DDG, DGHWi, dem DHV, der DGKJ und DGGG. (2k-Level, AWMF-Leitlinien-Register Nr. 024/006, Juli 2017)

Segerer¹,

Bührer²,

Kapellen³

et al. 2018

Z Geburtshilfe Neonatol

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“…Moreover, there is reportedly increased risk of preeclampsia, asymptomatic bacteriuria, pyelonephritis and cesarean delivery among women with GDM (11,12). Besides the adverse effects of GDM on the mother both in the short and long-terms, GDM was linked with many fetal and neonatal complications including macrosomia (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), shoulder dystocia (17), neonatal hypoglycemia (18) and congenital malformation (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Outdoor Air Pollution and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Elshahidi

2019

ijph

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Background: During the past 20 years, the prevalence of gestational diabetes mellitus (GDM) has increased by ∼10%-100% in several race/ethnicity groups. There is an association between ambient air pollution (AAP) and GDM. This study aimed to summarize the evidence about the association between AAP and GDM. Methods: PubMed, Embase, Scopus, Web of Science and Cochrane Library were searched from inception till Oct 2017. Studies about the association between ambient air pollutants levels and GDM were included. Pooled effect estimates and their 95% confidence interval (CI) were calculated using R. Results: Eight studies met the inclusion criteria. The odds of developing GDM upon exposure to CO (per 1 ppm), NO (per 1 ppb), NO2 (per 10 µg/m3), NOx (per 1 ppb), O3 (per 10 ppb), SO2 (per 10 ppb), PM10 (per 10 µg/m3) and PM2.5 (per 10 µg/m3) were 1.47 (95% CI 0.88-2.06), 1.04 (95% CI 1.03-1.06), 1 (95% CI 0.93-1.08), 1.02 (95% CI 1-1.04), 1.05 (95% CI 0.94-1.16), 1.39 (95% CI 1.04-1.73), 0.97 (95% CI 0.94-0.99) and 1.12 (95% CI 0.93-1.31), respectively. Conclusion: The current literature showed evidence for an association between AAP and GDM. However, further well-designed studies are needed.

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Association between maternal diabetes mellitus and the risk of congenital malformations: A meta-analysis of cohort studies

Cited by 42 publications

References 39 publications

Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)

Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)

Betreuung von Neugeborenen diabetischer Mütter. Leitlinie der GNPI, DGPM, DDG, DGHWi, dem DHV, der DGKJ und DGGG. (2k-Level, AWMF-Leitlinien-Register Nr. 024/006, Juli 2017)

Outdoor Air Pollution and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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