Association between maternal cervicovaginal swab positivity for Ureaplasma spp. or other microorganisms and neonatal respiratory outcome and mortality

Patients who have experienced acute critical condition and realized the “syndrome of the consequences of intensive care” become “chronic critical patients” and need long-term maintenance of vital functions of the body for many months and even years. The progressive development of resuscitation care with the improvement of respiratory and nutritional support, the introduction of new drugs and the development of modern algorithms for the treatment of critical conditions in children led to an improvement in survival rates among patients in intensive care units. At the same time, not all surviving patients end the trajectory of the disease by recovery and some children remain dependent on one or another type of protection of the function of organs and systems. There are conditions that require long-term maintenance of the body in a hospital: in the intensive care unit, in the PIT or in the palliative care unit. Prolonged invasive effects, aggressive nosocomial microbiota, immunodeficiency conditions lead to permanent contamination and the formation of infection loci. Periodically relapses, reactivations of bacterial inflammation are of a specific nature inherent in a chronic critical patient. Therapy of these exacerbations is complex and should be carried out taking into account the peculiarities of this category of patients. For the prevention of chronic critical condition, microbiological monitoring should be carried out taking into account the sensitivity to antibiotics in order to timely antibacterial therapy, and in some cases, antibiotic prophylaxis. The authors of the present review consider in detail the problem of microbial colonization in a chronic critical child on the example of various pathological conditions occurring with the formation of chronic lung disease. These issues should be considered by doctors of different levels of medical care in routine practice.

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Maternal Baseline Risk Factors for Abnormal Vaginal Colonisation among High-Risk Pregnant Women and the Association with Adverse Pregnancy Outcomes: A Retrospective Cohort Study

Jeon

Choi

Kim

et al. 2022

JCM

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Abnormal vaginal colonisation can lead to adverse pregnancy outcomes such as preterm birth through intra-amniotic inflammation. Despite the concern, little is known about its risk factors and impact in pregnant women at high-risk for spontaneous preterm birth. Thus, we conducted this single-centre retrospective cohort study including 1381 consecutive women who were admitted to the high-risk pregnancy unit. The results of vaginal culture at admission were categorised according to the colonising organism: bacteria (Gram-negative or -positive) and genital mycoplasmas. Maternal baseline socioeconomic, and clinical characteristics, as well as pregnancy, delivery, and neonatal outcomes were compared according to the category. Maternal risk factors for Gram-negative colonisation included advanced maternal age, increased pre-pregnancy BMI, a greater number of past spontaneous abortions, earlier gestational age at admission, and IVF. Gram-positive colonisation was likewise associated with earlier gestational age at admission. Genital mycoplasmal colonisation was associated with a greater number of past induced abortions, a lower level of education completed, and a lower rate of multifetal pregnancy and IVF. The neonates from mothers with Gram-negative colonisation had a greater risk of NICU admission, proven early onset neonatal sepsis, and mortality. However, not Gram-positive bacteria or genital mycoplasma was directly associated with adverse pregnancy outcomes.

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Association between maternal cervicovaginal swab positivity for Ureaplasma spp. or other microorganisms and neonatal respiratory outcome and mortality

Cited by 3 publications

References 66 publications

Maternal Ureaplasma exposure during pregnancy and the risk of preterm birth and BPD: a meta-analysis

Maternal Ureaplasma exposure during pregnancy and the risk of preterm birth and BPD: a meta-analysis

Chronic critical patient in pediatrics: microbiological “portrait” and problems of antibiotic resistance

Maternal Baseline Risk Factors for Abnormal Vaginal Colonisation among High-Risk Pregnant Women and the Association with Adverse Pregnancy Outcomes: A Retrospective Cohort Study

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