Association between Maternal Allergic Rhinitis and Asthma on the Prevalence of Atopic Disease in Offspring

Wang, Qiuping; Wu, Kunmin; Li, Zeqing; Chen, Wei; Ji, Han; Wang, Bingling

doi:10.1159/000328789

Cited by 18 publications

(18 citation statements)

References 83 publications

(48 reference statements)

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“…The importance of parental rhinitis as a risk factor for allergic rhinitis in their offspring is well understood [13,14], and the results of our study further emphasize this relationship. Children with at least one parent who suffered from allergic rhinitis were more likely to have the disease themselves.…”

Section: Discussionsupporting

confidence: 71%

Prevalence and risk factors for allergic rhinitis in two resource‐limited settings in Peru with disparate degrees of urbanization

Baumann

Romero

Robinson

et al. 2014

Clin Experimental Allergy

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Summary Background Allergic rhinitis is a disease with a high global disease burden, but risk factors that contribute to this condition are not well understood. Objective To assess the prevalence and risk factors of allergic rhinitis in two Peruvian populations with disparate degrees of urbanization. Methods We conducted a population-based, cross-sectional study on 1441 children aged 13–15 years at enrollment (mean age 14.9 years, 51% boys) to investigate the prevalence of allergic disease. We used a standardized, Spanish validated questionnaire to determine the prevalence of allergic rhinitis and asked about sociodemographics and family history of allergies. Children also underwent spirometry, exhaled nitric oxide, allergy skin testing to 10 common household allergens and provided a blood sample for measurement of 25OH vitamin D and total serum IgE. Results Overall prevalence of allergic rhinitis was 18% (95% CI 16% to 20%). When stratified by site, the prevalence of allergic rhinitis was 23% Lima vs. 13% in Tumbes (P < 0.001); however, this difference was no longer significant after controlling for subject- specific factors (P = 0.95). There was a strong association with other allergic diseases: 53% of children with asthma had allergic rhinitis vs. 15% in those without asthma (P < 0.001) and 42% of children with eczema vs. 17% of those without eczema (P < 0.001). Important risk factors for allergic rhinitis were parental rhinitis (adjusted OR = 3.0, 95% CI 1.9–4.7 for 1 parent and adjusted OR = 4.4, 95% CI 1.5–13.7 for 2 parents); allergic sensitization to common household aeroallergens (1.6, 1.1–2.3); being overweight (1.5, 1.0–2.3); exhaled nitric oxide ≥20 ppb (1.9, 1.3–2.7); and total serum IgE ≥ 95th percentile (2.4, 1.2–4.8). Population attributable risk of important factors for allergic rhinitis were 25% for high exhaled nitric oxide, 22% for allergic sensitization to common household aeroallergens, 22% for paternal rhinitis, 10% for being overweight and 7% for an elevated total serum IgE. Conclusion and Clinical Relevance Allergic rhinitis was prevalent in both settings, and important risk factors include elevated exhaled nitric oxide, allergic sensitization to common household aeroallergens, parental rhinitis, being overweight and high total serum IgE. When considering subject-specific factors, the difference in prevalence between the urban and rural settings became non-important.

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Section: Discussionsupporting

confidence: 71%

Prevalence and risk factors for allergic rhinitis in two resource‐limited settings in Peru with disparate degrees of urbanization

Baumann

Romero

Robinson

et al. 2014

Clin Experimental Allergy

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“…A more recent study also found that maternal asthma and allergic rhinitis were associated with increased risk of their offspring developing allergic conditions. 12 Residential proximity to busy roads was associated with respiratory symptoms. 13 , 14 As shown in Table 4, the prevalence of respiratory morbidity increased with increasing proximity of a child’s home to traffic.…”

Section: Discussionmentioning

confidence: 99%

Effects of Outdoor and Indoor Air Pollution on Respiratory Health of Chinese Children from 50 Kindergartens

Liu

Wang

Zhao

et al. 2013

Journal of Epidemiology

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BackgroundConcentrations of ambient air pollution and pollutants in China have changed considerably during the last decade. However, few studies have evaluated the effects of current ambient air pollution on the health of kindergarten children.MethodsWe studied 6730 Chinese children (age, 3–7 years) from 50 kindergartens in 7 cities of Northeast China in 2009. Parents or guardians completed questionnaires that asked about the children’s histories of respiratory symptoms and risk factors. Three-year concentrations of particles with an aerodynamic diameter ≤10 µm (PM10), sulfur dioxide (SO2), and nitrogen dioxides (NO2) were calculated at monitoring stations in 25 study districts. A 2-stage regression approach was used in data analyses.ResultsThe prevalence of respiratory symptoms was higher among children living near a busy road, those living near chimneys or a factory, those having a coal-burning device, those living with smokers, and those living in a home that had been recently renovated. Among girls, PM10 was associated with persistent cough (odds ratio [OR]PM10 = 1.44; 95% CI, 1.18–1.77), persistent phlegm (ORPM10 = 1.36; 95% CI, 1.02–1.81), and wheezing (ORPM10 = 1.31; 95% CI, 1.04–1.65). NO2 concentration was associated with increased prevalence of allergic rhinitis (OR = 1.96; 95% CI, 1.27–3.02) among girls. In contrast, associations of respiratory symptoms with concentrations of PM10, SO2, and NO2 were not statistically significant among boys.ConclusionsAir pollution is particularly important in the development of respiratory morbidity among children. Girls may be more susceptible than boys to air pollution.

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“…Traherne et al [34] showed that a polymorphism of the high-affinity IgE receptor beta-chain (FceRI-ß) was strongly associated with positive skin prick test results and greater allergen-specific IgE levels when inherited from mothers. The severity of maternal allergic rhinitis, asthma comorbidity, elevated serum IgE levels, and nasal eosinophilia were all associated with an increased risk of offspring developing [35]. On the other hand, Sunyer et al [36] evaluated mothers and their children from the Asthma Multi-centre Infants Cohort Study (AMICS), with the aim of examining the effects of pre-and postnatal environmental exposure in the inception of atopy and asthma.…”

Section: Atopymentioning

confidence: 99%

Early Life Origins of Asthma: A Review of Potential Effectors

Bobolea¹,

Arismendi²,

Valero³

et al. 2019

J Investig Allergol Clin Immunol

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There is growing evidence that events occurring early in life, both before and after birth, are significantly associated with the risk of asthma, chronic obstructive pulmonary disease, and diminished lung function later in life. In fact, from conception to death, a series of continuous, dynamic gene-environment interactions determine 2 fundamental biological processes, namely, lung development and lung aging. Over 130 birth cohorts have been initiated in the last 30 years. Data from these cohorts have improved our understanding of the inception, progression, and persistency of asthma. In this review, we summarize the main data for the early life events proven to determine later development and persistence of asthma, such as maternal atopy and smoking, preterm birth/bronchopulmonary dysplasia, infections, nutrition, obesity, smoking, and other environmental exposures in childhood and adolescence. While some of these factors are obviously impossible to prevent or eliminate, others have been proven to have a protective role, and current research is aimed optimizing them. Available prophylactic measures are also reviewed. In the case of environmental pollution, large scale political interventions successfully managed to decrease contamination levels, leading to improved lung function and lower asthma prevalence in the respective geographical areas. Future research should focus on better understanding these complex interactions in order to develop and enhance effective preventive therapeutic measures. ResumenExiste evidencia de que eventos que ocurren en fases tempranas de la vida, tanto antes como después del nacimiento, se asocian significativamente con el aumento del riesgo futuro de asma, enfermedad pulmonar obstructiva crónica y deterioro de la función pulmonar. En efecto, desde el momento de la concepción hasta la muerte, una serie de interacciones dinámicas y continuas genético-ambientales determinan dos procesos biológicos fundamentales, el desarrollo pulmonar y el envejecimiento pulmonar. En los últimos 30 años se han comenzado más de 130 cohortes de nacimiento. Los datos de estas cohortes han mejorado nuestra comprensión del inicio, la progresión y la persistencia del asma. En esta revisión, resumimos los datos principales de los eventos de la vida temprana probados que determinan el desarrollo y la persistencia posteriores del asma, como atopia materna y tabaquismo, parto prematuro/displasia broncopulmonar, infecciones, nutrición, obesidad, tabaquismo y otras exposiciones ambientales en la infancia y la adolescencia. Si bien algunos de estos factores son obviamente imposibles de prevenir o eliminar, se ha demostrado que otros tienen un papel protector, y la investigación actual apunta a optimizarlos. También se revisan las medidas profilácticas disponibles. En el caso de la contaminación ambiental, las intervenciones políticas a gran escala lograron disminuir los niveles de contaminación, lo que mejoró la función pulmonar y disminuyó la prevalencia de asma en las respectivas áreas geográficas. Las investiga...

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Association between Maternal Allergic Rhinitis and Asthma on the Prevalence of Atopic Disease in Offspring

Cited by 18 publications

References 83 publications

Prevalence and risk factors for allergic rhinitis in two resource‐limited settings in Peru with disparate degrees of urbanization

Prevalence and risk factors for allergic rhinitis in two resource‐limited settings in Peru with disparate degrees of urbanization

Effects of Outdoor and Indoor Air Pollution on Respiratory Health of Chinese Children from 50 Kindergartens

Early Life Origins of Asthma: A Review of Potential Effectors

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